Ambulatory Use of Handheld Point-of-Care Ultrasound (HH-POCUS) in Rural Brandenburg - A Pilot Study
CONCLUSION: HH-POCUS helped doctors in rural areas to optimize patient care through rapid on-site collection of therapeutically relevant findings. In addition, it was shown that specialized and motivated nurses can independently detect simple ultrasound findings and thus provide clinically relevant information to doctors.PMID:33626573 | DOI:10.1055/a-1354-5958 (Source: Ultraschall in der Medizin)
Source: Ultraschall in der Medizin - February 24, 2021 Category: Radiology Authors: Hendra Lo Vilmar Frauendorf Sandra Wischke Christin Schimmath-Deutrich Markus Kersten Maria Nuernberg Dieter Nuernberg Christian Jenssen Source Type: research

Ambulatory Use of Handheld Point-of-Care Ultrasound (HH-POCUS) in Rural Brandenburg - A Pilot Study
CONCLUSION: HH-POCUS helped doctors in rural areas to optimize patient care through rapid on-site collection of therapeutically relevant findings. In addition, it was shown that specialized and motivated nurses can independently detect simple ultrasound findings and thus provide clinically relevant information to doctors.PMID:33626573 | DOI:10.1055/a-1354-5958 (Source: Ultraschall in der Medizin)
Source: Ultraschall in der Medizin - February 24, 2021 Category: Radiology Authors: Hendra Lo Vilmar Frauendorf Sandra Wischke Christin Schimmath-Deutrich Markus Kersten Maria Nuernberg Dieter Nuernberg Christian Jenssen Source Type: research

Molecules, Vol. 26, Pages 1212: Sigma-1 Receptor Agonist TS-157 Improves Motor Functional Recovery by Promoting Neurite Outgrowth and pERK in Rats with Focal Cerebral Ischemia
o Pang Li-Fang Yu Sigma-1 (σ-1) receptor agonists are considered as potential treatment for stroke. TS-157 is an alkoxyisoxazole-based σ-1 receptor agonist previously discovered in our group. The present study describes TS-157 profile in a battery of tests for cerebral ischemia. Initial evaluation demonstrated the compound’s safety profile and blood–brain barrier permeability, as well as its ability to induce neurite outgrowth in vitro. The neurite outgrowth was shown to be mediated via σ-1 receptor agonism and involves upregulation of ERK phosphorylation (pERK). In particular, TS-157 al...
Source: Molecules - February 24, 2021 Category: Chemistry Authors: Jun-Jie Shi Qi-Hui Jiang Tian-Ning Zhang Hao Sun Wen-Wen Shi Hendra Gunosewoyo Fan Yang Jie Tang Tao Pang Li-Fang Yu Tags: Article Source Type: research

Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases
The World Health Organization (WHO) monitors the spread of diseases globally and maintains a list of diseases with epidemic or pandemic potential. Currently listed diseases include Chikungunya, cholera, Crimean-Congo hemorrhagic fever, Ebola virus disease, Hendra virus infection, influenza, Lassa fever, Marburg virus disease, Neisseria meningitis, MERS-CoV, monkeypox, Nipah virus infection, novel coronavirus (COVID-19), plague, Rift Valley fever, SARS, smallpox, tularemia, yellow fever, and Zika virus disease. The associated pathogens are increasingly important on the global stage. The majority of these diseases have neuro...
Source: Frontiers in Neurology - February 22, 2021 Category: Neurology Source Type: research

Effect of PCSK9 E670G and R46L Polymorphisms on Major Adverse Cardio-Cerebrovascular Events in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Int J Angiol DOI: 10.1055/s-0041-1722875Major adverse cardio-cerebrovascular events (MACCE) in ST-segment elevation myocardial infarction (STEMI) are still high, although there have been advances in pharmacology and interventional procedures. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) is a serine protease regulating lipid metabolism associated with inflammation in acute coronary syndrome. The MACCE is possibly related to polymorphisms in PCSK9. A prospective cohort observational study was designed to confirm the association between polymorphism of E670G and R46L in the PCSK9 gene with MACCE in STEMI. The Cox pro...
Source: International Journal of Angiology - February 18, 2021 Category: Cardiology Authors: Santoso, Anwar Yulianto, Yulianto Simarmata, Hendra Putra, Abhirama Nofandra Listiyaningsih, Erlin Tags: Invited Paper Source Type: research

Paramyxovirus circulation in bat species from French Guiana.
Abstract Bats are recognized as reservoirs of numerous viruses. Among them, paramyxoviruses, for example, Hendra and Nipah viruses, are highly pathogenic to humans. Nothing is known regarding the circulation of this viral family in bats from French Guiana. To search for the presence of paramyxoviruses in this territory, 103 bats of seven different species were sampled and screened using a molecular approach. Four distinct paramyxovirus sequences were detected from three bat species (Desmodus rotundus, Carollia perspicillata, and Pteronotus alitonus) at high prevalence rates. In D. rotundus, two types of paramyxovi...
Source: Infection, Genetics and Evolution - February 12, 2021 Category: Genetics & Stem Cells Authors: Darcissac E, Donato D, de Thoisy B, Lacoste V, Lavergne A Tags: Infect Genet Evol Source Type: research

Identifying prognostic risk factors for poor outcome following COVID-19 disease among in-centre haemodialysis patients: role of inflammation and frailty.
Abstract INTRODUCTION: The pandemic of coronavirus disease (COVID-19) has highly affected patients with comorbidities and frailty who cannot self-isolate, such as individuals undergoing haemodialysis. The aim of the study was to identify risk factors for mortality and hospitalisation, which may be useful in future disease spikes. METHODS: We collected data retrospectively from the electronic medical records of all patients receiving a diagnosis of COVID-19 between 11th March and 10th May 2020 undergoing maintenance haemodialysis at four satellite dialysis units from the Royal Free London NHS Foundation T...
Source: Journal of Nephrology - January 30, 2021 Category: Urology & Nephrology Authors: Hendra H, Vajgel G, Antonelou M, Neradova A, Manson B, Clark SG, Kostakis ID, Caplin B, Salama AD Tags: J Nephrol Source Type: research

Viruses, Vol. 13, Pages 169: The Ecology of Nipah Virus in Bangladesh: A Nexus of Land-Use Change and Opportunistic Feeding Behavior in Bats
ily S. Gurley Nipah virus is a bat-borne paramyxovirus that produces yearly outbreaks of fatal encephalitis in Bangladesh. Understanding the ecological conditions that lead to spillover from bats to humans can assist in designing effective interventions. To investigate the current and historical processes that drive Nipah spillover in Bangladesh, we analyzed the relationship among spillover events and climatic conditions, the spatial distribution and size of Pteropus medius roosts, and patterns of land-use change in Bangladesh over the last 300 years. We found that 53% of annual variation in winter spillovers is explai...
Source: Viruses - January 23, 2021 Category: Virology Authors: Clifton D. McKee Ausraful Islam Stephen P. Luby Henrik Salje Peter J. Hudson Raina K. Plowright Emily S. Gurley Tags: Article Source Type: research

[ASAP] Alizarin Grafting onto Ultrasmall ZnO Nanoparticles: Mode of Binding, Stability, and Colorant Studies
LangmuirDOI: 10.1021/acs.langmuir.0c02981 (Source: Langmuir)
Source: Langmuir - January 20, 2021 Category: Chemistry Authors: Michel P. de Haan, Naveen Balakrishnan, Andriy R. Kuzmyn, Guanna Li, Hendra M. Willemen, Gunnar Seide, Goverdina C. H. Derksen, Bauke Albada, and Han Zuilhof Source Type: research

Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein
Publication date: 10 December 2020Source: Cell, Volume 183, Issue 6Author(s): Jinhui Dong, Robert W. Cross, Michael P. Doyle, Nurgun Kose, Jarrod J. Mousa, Edward J. Annand, Viktoriya Borisevich, Krystle N. Agans, Rachel Sutton, Rachel Nargi, Mahsa Majedi, Karla A. Fenton, Walter Reichard, Robin G. Bombardi, Thomas W. Geisbert, James E. Crowe (Source: Cell)
Source: Cell - December 12, 2020 Category: Cytology Source Type: research

A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease.
Authors: Gentles AD, Guth S, Rozins C, Brook CE Abstract The emergence of SARS-CoV-2, a coronavirus with suspected bat origins, highlights a critical need for heightened understanding of the mechanisms by which bats maintain potentially zoonotic viruses at the population level and transmit these pathogens across species. We review mechanistic models, which test hypotheses of the transmission dynamics that underpin viral maintenance in bat systems. A search of the literature identified only twenty-five mechanistic models of bat-virus systems published to date, derived from twenty-three original studies. Most models ...
Source: Pathogens and Global Health - November 17, 2020 Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research

Genetic Diversity of Nipah virus in Bangladesh
Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus causing severe respiratory disease and encephalitis in Southeast Asia with high mortality (Luby and Gurley, 2012, Satterfield et al., 2016). It is a negative stranded RNA virus with a large genome of 18 Kb and is classified in the Henipaviruses genus of Paramyxoviridae family along with its close relatives: Hendra virus, Cedar virus and Mojiang virus (Rockx et al., 2012). NiV has an envelope with filamentous nucleocapsids containing a genome of six major structural proteins (N-P-M-F-G-L). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 28, 2020 Category: Infectious Diseases Authors: M.Z. Rahman, M.M. Islam, M.E. Hossain, M.M. Rahman, A. Islam, A. Siddika, M.S.S. Hossain, S. Sultana, A. Islam, M. Rahman, M. Rahman, J.D. Klena, M.S. Flora, P. Daszak, J.H. Epstein, S.P. Luby, E.S. Gurley Source Type: research

Development of an intelligent mobile health monitoring system for the health surveillance system in Indonesia
Publication date: Available online 9 October 2020Source: IRBMAuthor(s): Yasser Abd Djawad, Sutarsi Suhaeb, Ridwansyah, Hendra Jaya, Fathahillah, Saharuddin (Source: IRBM)
Source: IRBM - October 11, 2020 Category: Biomedical Engineering Source Type: research

Neuroimaging in Zoonotic Outbreaks Affecting the Central Nervous System: Are We Fighting the Last War? [ADULT BRAIN]
SUMMARY: When preparing for the coronavirus disease 2019 pandemic and its effects on the CNS, radiologists should be familiar with neuroimaging appearances in past zoonotic infectious disease outbreaks. Organisms that have crossed the species barrier from animals to humans include viruses such as Hendra, Nipah, Severe Acute Respiratory Syndrome, and influenza, as well as bacteria and others. Brain CT and MR imaging findings have included cortical abnormalities, microinfarction in the white matter, large-vessel occlusion, and features of meningitis. In particular, the high sensitivity of diffusion-weighted MR imaging in det...
Source: American Journal of Neuroradiology - October 5, 2020 Category: Radiology Authors: Goh, G. X., Tan, K., Ang, B. S. P., Wang, L.- F., Tchoyoson Lim, C. C. Tags: ADULT BRAIN Source Type: research

New Guinea highland wild dogs are the original New Guinea singing dogs [Genetics]
New Guinea singing dogs (NGSD) are identifiable by their namesake vocalizations, which are unlike any other canid population. Their novel behaviors and potential singular origin during dog domestication make them an attractive, but elusive, subject for evolutionary and conservation study. Although once plentiful on the island of New Guinea (NG),... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 28, 2020 Category: Science Authors: Suriani Surbakti, Heidi G. Parker, James K. McIntyre, Hendra K. Maury, Kylie M. Cairns, Meagan Selvig, Margaretha Pangau-Adam, Apolo Safonpo, Leonardo Numberi, Dirk Y. P. Runtuboi, Brian W. Davis, Elaine A. Ostrander Tags: Biological Sciences Source Type: research

Dietary Knowledge, Preferences and Behaviors in Ramadan among Muslim Patients with Type 2 Diabetes
To explore the association between dietary knowledge, attitude, and practices during Ramadan among Muslim patients with type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 27, 2020 Category: Endocrinology Authors: Yi-Tien Hsu, Hsin-Jen Chen, Amanda Yufika, Hendra Zufry Source Type: research

Methods for sequence and structural analysis of B and T cell receptor repertoires
Publication date: Available online 17 July 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Shunsuke Teraguchi, Dianita S. Saputri, Mara Anais Llamas-Covarrubias, Ana Davila, Diego Diez, Sedat Aybars Nazlica, John Rozewicki, Hendra S. Ismanto, Jan Wilamowski, Jiaqi Xie, Zichang Xu, Martin de Jesus Loza-Lopez, Floris J. van Eerden, Songling Li, Daron M. Standley (Source: Computational and Structural Biotechnology Journal)
Source: Computational and Structural Biotechnology Journal - July 17, 2020 Category: Biotechnology Source Type: research

The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway.
ord M Abstract The anti-malarial drug Chloroquine (CQ) and its derivative hydroxychloroquine have shown antiviral activities in vitro against many viruses, including coronaviruses, dengue virus and the biosafety level 4 Nipah and Hendra paramyxoviruses. The in vivo efficacy of CQ in the treatment of COVID-19 is currently a matter of debate. CQ is a lysosomotrophic compound that accumulates in lysosomes, as well as in food vacuoles of Plasmodium falciparum. In the treatment of malaria, CQ impairs the digestion and growth of the parasite by increasing the pH of the food vacuole. Similarly, it is assumed that the ant...
Source: Biochimie - May 29, 2020 Category: Biochemistry Authors: Carrière F, Longhi S, Record M Tags: Biochimie Source Type: research

Viruses, Vol. 12, Pages 480: Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice
unjie Xu Wei Chen The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia–Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana virus (GhV) and Mojiang virus (MojV), are speculated to be associated with unrecognized human diseases in Africa and China, respectively. Despite many efforts to develop vaccines against henipaviral diseases, there is presently no licensed human vaccine. As HNVs are highly pathogenic and diverse, it is necessary to develop universal va...
Source: Viruses - April 22, 2020 Category: Virology Authors: Yaohui Li Ruihua Li Meirong Wang Yujiao Liu Ying Yin Xiaodong Zai Xiaohong Song Yi Chen Junjie Xu Wei Chen Tags: Article Source Type: research

Parcel Locker as the Alternative of Parcel Delivery Service of Online Shopping
(Source: Journal of Computational and Theoretical Nanoscience)
Source: Journal of Computational and Theoretical Nanoscience - April 19, 2020 Category: Nanotechnology Authors: Gunawan, Hendra Nahry Kusuma, Andyka Abdullah, Sarini Tags: research-article Source Type: research

Information Delivery And The Veterinarian-Horse Owner Relationship In The Context Of Hendra Virus In Australia
Publication date: Available online 13 April 2020Source: Preventive Veterinary MedicineAuthor(s): Charis Hii, Navneet K. Dhand, Jenny-Ann L.M.L. Toribio, Melanie R. Taylor, Anke Wiethoelter, Nicole Schembri, Kate Sawford, Nina Kung, Barbara Moloney, Therese Wright, Hume Field, Kathrin Schemann (Source: Preventive Veterinary Medicine)
Source: Preventive Veterinary Medicine - April 14, 2020 Category: Veterinary Research Source Type: research

False positive finding from malignancy-like lesions on FDG PET/CT: case report of tuberculosis patients
The F-18 fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) has become an established diagnostic imaging for malignancy. However, there are other diseases that can also be identified with FD... (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - March 5, 2020 Category: Radiology Authors: Febby Hutomo, Ryan Yudistiro, Ivana Dewi Mulyanto and Hendra Budiawan Tags: Case report Source Type: research

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis [Microbiology]
Research in the last decade has uncovered many new paramyxoviruses, airborne agents that cause epidemic diseases in animals including humans. Most paramyxoviruses enter epithelial cells of the airway using sialic acid as a receptor and cause only mild disease. However, others cross the epithelial barrier and cause more severe disease. For some of these viruses, the host receptors have been identified, and the mechanisms of cell entry have been elucidated. The tetrameric attachment proteins of paramyxoviruses have vastly different binding affinities for their cognate receptors, which they contact through different binding s...
Source: Journal of Biological Chemistry - February 27, 2020 Category: Chemistry Authors: Chanakha K. Navaratnarajah, Alex R. Generous, Iris Yousaf, Roberto Cattaneo Tags: JBC Reviews Source Type: research

Identifying optimal indicators and purposes of population segmentation through engagement of key stakeholders: a qualitative study
Various population segmentation tools have been developed to inform the design of interventions that improve population health. However, there has been little consensus on the core indicators and purposes of p... (Source: Health Research Policy and Systems)
Source: Health Research Policy and Systems - February 21, 2020 Category: International Medicine & Public Health Authors: Sungwon Yoon, Hendra Goh, Yu Heng Kwan, Julian Thumboo and Lian Leng Low Tags: Research Source Type: research

From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses
Publication date: Available online 11 February 2020Source: The LancetAuthor(s): Lin-Fa Wang, Danielle E Anderson, John S Mackenzie, Michael H Merson (Source: The Lancet)
Source: The Lancet - February 12, 2020 Category: General Medicine Source Type: research

Comparing the EQ-5D-3  L and EQ-5D-5 L: studying measurement and scores in Indonesian type 2 diabetes mellitus patients
The EuroQoL five-dimensional instrument (EQ-5D) is the favoured preference-based instrument to measure health-related quality of life (HRQoL) in several countries. Two versions of the EQ-5D are available: the ... (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - February 7, 2020 Category: International Medicine & Public Health Authors: Bustanul Arifin, Fredrick Dermawan Purba, Hendra Herman, John M. F. Adam, Jarir Atthobari, Catharina C. M. Schuiling-Veninga, Paul F. M. Krabbe and Maarten J. Postma Tags: Research Source Type: research

Caring for Terminally-Ill Incarcerated Patients: What to Say, Ask, and Do Across Different Settings (SA527)
The United States criminal justice system holds approximately 2.3 million people in correctional facilities —state and federal prisons, jails, and juvenile facilities—which disproportionately impacts people of color and low income. Incarcerated individuals 55 years or older account for four times the healthcare cost compared to their younger counterparts. They often experience accelerated aging becaus e of substance use disorders, insufficient primary care screening, and stress associated with incarceration. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - January 25, 2020 Category: Palliative Care Authors: Anna H. Chon, Zankhana Y. Mehta, Molly Padgett, Corinne Hendra, Arianne Napier Source Type: research

“Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SM... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - December 30, 2019 Category: Gastroenterology Authors: Yan Mardian, Yoshihiko Yano, Neneng Ratnasari, Lina Choridah, Widya Wasityastuti, Nurhuda Hendra Setyawan and Yoshitake Hayashi Tags: Research article Source Type: research

Cancers, Vol. 11, Pages 1786: Therapeutic Inducers of Apoptosis in Ovarian Cancer
nto Yu Yu Ovarian cancers remain one of the most common causes of gynecologic cancer-related death in women worldwide. The standard treatment comprises platinum-based chemotherapy, and most tumors develop resistance to therapeutic drugs. One mechanism of developing drug resistance is alterations of molecules involved in apoptosis, ultimately assisting in the cells’ capability to evade death. Thus, there is a need to focus on identifying potential drugs that restore apoptosis in cancer cells. Here, we discuss the major inducers of apoptosis mediated through various mechanisms and their usefulness as pote...
Source: Cancers - November 12, 2019 Category: Cancer & Oncology Authors: Mudra Binju Monica Angelica Amaya-Padilla Graeme Wan Hendra Gunosewoyo Yohan Suryo Rahmanto Yu Yu Tags: Review Source Type: research

Frequent testicular involvement in multibacillary leprosy
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 17, 2019 Category: Infectious Diseases Authors: Hendra Gunawan, Pati Aji Achdiat, Rachel Marsella Rahardjo, Reti Hindritiani, Oki Suwarsa Source Type: research

Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus [Microbiology]
Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra virus (HeV), zoonotic agents of fatal human disease. CedV receptor-binding protein (G) shares only ∼30% sequence identity with those of NiV and HeV, although they can all use ephrin-B2 as an entry receptor. We demonstrate that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Eric D. Laing, Chanakha K. Navaratnarajah, Sofia Cheliout Da Silva, Stephanie R. Petzing, Yan Xu, Spencer L. Sterling, Glenn A. Marsh, Lin-Fa Wang, Moushimi Amaya, Dimitar B. Nikolov, Roberto Cattaneo, Christopher C. Broder, Kai Xu Tags: Biological Sciences Source Type: research

Optimization and Diagnostic Evaluation of Monoclonal Antibody-based Blocking ELISA Formats for Detection of Neutralizing Antibodies to Hendra Virus in Mammalian Sera.
Abstract Maintenance of Hendra virus (HeV) in pteropid bat populations has been associated with spillover events in horses, humans and dogs. Experimental studies have demonstrated infections for several other species including guinea pigs, cats and ferrets. The criteria of a sensitive and specific serological test that is effective for a range of species, but which does not require use of live virus, has not been satisfactorily addressed by currently available tests. We have evaluated the use of two HeV neutralizing monoclonal antibodies (mAbs) in a blocking format enzyme-linked immunosorbent assay (bELISA) to det...
Source: Journal of Virological Methods - September 8, 2019 Category: Virology Authors: Di Rubbo A, McNabb L, Klein R, White JR, Colling A, Dimitrov DS, Broder C, Middleton D, Lunt R Tags: J Virol Methods Source Type: research

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats
by Dan Lu, Kefang Liu, Di Zhang, Can Yue, Qiong Lu, Hao Cheng, Liang Wang, Yan Chai, Jianxun Qi, Lin-Fa Wang, George F. Gao, William J. Liu Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01– binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenz...
Source: PLoS Biology: Archived Table of Contents - September 8, 2019 Category: Biology Authors: Dan Lu Source Type: research

Henipavirus-like particles induce a CD8 T cell response in C57BL/6 mice
Publication date: Available online 3 September 2019Source: Veterinary MicrobiologyAuthor(s): Eileen Stroh, Kerstin Fischer, Theresa Schwaiger, Lucie Sauerhering, Kati Franzke, Andrea Maisner, Martin H Groschup, Ulrike Blohm, Sandra DiederichAbstractNipah virus (NiV), a BSL-4 pathogen, belongs to the genus Henipavirus within the family Paramyxoviridae. To date, no effective vaccine is available. Although most of the current vaccine studies aim to induce a neutralizing antibody response, it has become evident that a promising vaccine should target both, humoral and cell-mediated immune response. Virus-like particles (VLPs) h...
Source: Veterinary Microbiology - September 4, 2019 Category: Veterinary Research Source Type: research

Using peer education to improve diabetes management and outcomes in a low-income setting: a randomized controlled trial
Diabetes is an important health burden in Indonesia. However, diabetes management and treatment remain poor, with most people with diabetes in Indonesia not achieving the recommended blood glucose levels. Peer... (Source: Trials)
Source: Trials - September 2, 2019 Category: General Medicine Authors: Till Seuring, Marthoenis, Sabrina Rhode, Lisa Rogge, Holger Rau, St éphane Besançon, Hendra Zufry, Hizir Sofyan and Sebastian Vollmer Tags: Study protocol Source Type: research

Viruses, Vol. 11, Pages 800: Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein
Nadine Krüger The Ghana virus (GhV) is phylogenetically related to the zoonotic henipaviruses Nipah (NiV) and Hendra virus. Although GhV uses the highly conserved receptor ephrin-B2, the fusogenicity is restricted to cell lines of bat origin. Furthermore, the surface expression of the GhV attachment glycoprotein (G) is reduced compared to NiV and most of this protein is retained in the endoplasmic reticulum (ER). Here, we generated truncated as well as chimeric GhV G proteins and investigated the influence of the structural domains (cytoplasmic tail, transmembrane domain, ectodomain) of this protein on the intrac...
Source: Viruses - August 28, 2019 Category: Virology Authors: Kathleen Voigt Markus Hoffmann Jan Felix Drexler Marcel Alexander M üller Christian Drosten Georg Herrler Nadine Kr üger Tags: Article Source Type: research

Cooperative defect-enriched SiO2 for oxygen activation and organic dehydrogenation
Publication date: August 2019Source: Journal of Catalysis, Volume 376Author(s): Wibawa Hendra Saputera, Hassan A. Tahini, Emma C. Lovell, Tze Hao Tan, Aditya Rawal, Kondo-Francois Aguey-Zinsou, Donia Friedmann, Sean C. Smith, Rose Amal, Jason ScottAbstractTailoring oxide functionalities via defect engineering is an effective approach in many advanced materials. Here we report that introducing defect sites in SiO2 via sequential hydrogenation and UV light pre-treatment steps can invoke synergism for oxygen activation and organic dehydrogenation under ambient conditions in the absence of light. The hydrogenation step is prop...
Source: Journal of Catalysis - July 20, 2019 Category: Chemistry Source Type: research

Giant bladder stone with history of recurrence urinary tract infections: A rare case
Publication date: September 2019Source: Urology Case Reports, Volume 26Author(s): Eriawan Agung Nugroho, Dila Junita, Yanuar Hendra WijayaAbstractGiant bladder stone more than 100 g is a rare finding and commonly associated with urinary tract infection. 32-year-old male came with history of lower abdominal pain, dysuria for 2 years. Patient had history of recurrence urinary tract infections for past 1 year and also complaint pollakiuria, incomplete emptying and hematuria. Abdominal radiograph and ultrasound revealed round calcified pelvic calculi. Patient received antibiotic and underwent open cystolithotomy. Extirpated ...
Source: Urology Case Reports - June 19, 2019 Category: Urology & Nephrology Source Type: research

Giant Bladder Stone with History of Recurrence Urinary Tract Infection:A Rare Case
Publication date: Available online 12 June 2019Source: Urology Case ReportsAuthor(s): Eriawan Agung Nugroho, Dila Junita, Yanuar Hendra WijayaAbstractGiant bladder stone more than 100 grams is a rare finding and commonly associated with urinary tract infection. 32-year-old male came with history of lower abdominal pain, dysuria for 2 years. Patient had history of recurrence urinary tract infection for past 1 year and also complaint pollakiuria, incomplete emptying and hematuria. Abdominal radiograph and ultrasound revealed round calcified pelvic calculi. Patient received antibiotic and underwent open cystolithotomy. Extirp...
Source: Urology Case Reports - June 12, 2019 Category: Urology & Nephrology Source Type: research

Enhanced Bone Regeneration Capability of Chitosan Sponge Coated with TiO2 Nanoparticles
Publication date: Available online 5 June 2019Source: Biotechnology ReportsAuthor(s): Radyum Ikono, Ni Li, Nanda Hendra Pratama, Agnia Vibriani, Diah RetnoYuniarni, Muhammad Luthfansyah, Boy Muchlis Bachtiar, EndangWiniati Bachtiar, KamarzaMulia, Mohammad Nasikin, Hideaki Kagami, Xianqi Li, Etik Mardliyati, Nurul Taufiqu Rochman, Tokiko Nagamura-Inoue, Arinobu TojoAbstractChitosan has been a popular option for tissue engineering, however exhibits limited function for bone regeneration due to its low mechanical robustness and non-osteogenic inductivity. Here we hybridized chitosan with TiO2 nanoparticles to improve its bone...
Source: Biotechnology Reports - June 6, 2019 Category: Biotechnology Source Type: research

A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
Source: PLoS Neglected Tropical Diseases - June 5, 2019 Category: Tropical Medicine Authors: Neeltje van Doremalen Source Type: research

Distal ureteric rupture caused by blunt abdominal trauma: A rare case report
Publication date: Available online 23 May 2019Source: Urology Case ReportsAuthor(s): Eriawan Agung Nugroho, Dony Kurniadi Wibowo, Yanuar Hendra Wijaya, Ivani Yunita KorwaAbstractUreteral trauma is a rare case and generally results from severe trauma events. A 6-year-old boy came with the chief complaint open wound in the lower right abdomen after falling from the bike. Abdominal MSCT with contrast showed the free liquid in the peritoneal cavity, and Retrograde Pyelogram showed the contrast extravasation. According to the algorithm, a surgical exploration must be performed because of the contrast extravasation. In this case...
Source: Urology Case Reports - May 23, 2019 Category: Urology & Nephrology Source Type: research

Analysis of Nipah Virus Codon Usage and Adaptation to Hosts
A recent outbreak of Nipah virus (NiV) in India has caused 17 deaths among people living in districts of Kerala state. Its zoonotic nature as well as high rate of human-to-human transmission has led researchers worldwide to work high for understanding the different aspects of the NiV. We performed a codon usage analysis based on publicly available nucleotide sequences of NiV and its host adaptation along with other members of genus Henipavirus in ten hosts. NiV genome encodes nine open reading frames; and overall, no significant bias in codon usage was observed. Aromaticity of proteins had no impact on codon usage. An anal...
Source: Frontiers in Microbiology - May 7, 2019 Category: Microbiology Source Type: research

Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review
Jassy Mary S. Lazarte1, Kim D. Thompson2 and Tae Sung Jung1* 1Laboratory of Aquatic Animal Diseases, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea 2Moredun Research Institute, Pentlands Science Park, Penicuik, United Kingdom Teleost fish, as with other vertebrates, rely on their innate immune system as a first line of defense against invading pathogens. A very important characteristic of the innate immune response is its ability to recognize conserved molecular structures, such as viral dsRNA and ssRNA. Mda5 is one of the three pattern recognition receptors (PRRs) that recogn...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Construction of the safe neutralizing assay system using pseudotyped Nipah virus and G protein-specific monoclonal antibody.
Abstract Nipah virus (NiV) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. Due to its high pathogenicity and mortality rates, NiV requires handling in biosafety level-4 (BSL-4) containment facilities and no effective vaccines or therapeutic agents are currently available. Since current diagnostic tests for detecting serum neutralizing antibodies against NiV mainly employ live viruses, establishment of more safe and robust alternative diagnostic methods is an essential medical requirement. Here, we have developed ...
Source: Biochemical and Biophysical Research communications - April 13, 2019 Category: Biochemistry Authors: Bae SE, Kim SS, Moon ST, Cho YD, Lee H, Lee JY, Shin HY, Lee HJ, Kim YB Tags: Biochem Biophys Res Commun Source Type: research

[ASAP] Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against < italic toggle="yes" > Mycobacterium tuberculosis < /italic > . Part II
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b00010 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 27, 2019 Category: Chemistry Authors: Wei Zhang, Shichun Lun, Ling-Ling Liu, Shiqi Xiao, Guanfu Duan, Hendra Gunosewoyo, Fan Yang, Jie Tang, William R. Bishai, Li-Fang Yu Source Type: research

Viruses, Vol. 11, Pages 215: Can Bats Serve as Reservoirs for Arboviruses?
ing Bats are known to harbor and transmit many emerging and re-emerging viruses, many of which are extremely pathogenic in humans but do not cause overt pathology in their bat reservoir hosts: henipaviruses (Nipah and Hendra), filoviruses (Ebola and Marburg), and coronaviruses (SARS-CoV and MERS-CoV). Direct transmission cycles are often implicated in these outbreaks, with virus shed in bat feces, urine, and saliva. An additional mode of virus transmission between bats and humans requiring further exploration is the spread of disease via arthropod vectors. Despite the shared ecological niches that bats fill with many h...
Source: Viruses - March 2, 2019 Category: Virology Authors: Anna C. Fagre Rebekah C. Kading Tags: Review Source Type: research

Excretion dynamics of Henipa-related viruses in the Egyptian Rousette bat and triggers for potential spillover
This study investigated the presence of Henipa- and related viruses in the Egyptian Rousette bat in South Africa as well as determining potential excretion in urine over time. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - January 31, 2019 Category: Infectious Diseases Authors: M. Mortlock, M. Dietrich, J. Weyer, J. Paweska, W. Markotter Tags: 19.007 Source Type: research

Hendra virus in the field – risk profiling and management
Purpose: Hendra virus is a zoonotic pathogen which was first identified in 1994 and spillover events in horses were sporadic in Queensland (QLD) and New South Wales (NSW), Australia until 2010. The predominant differences during 2011-2017 were the number of spillover events (46 incidents during 2011-2017 compared to 14 incidents during 1994-2010), the unprecedented number of incidents in NSW (19 incidents during 2011-2017 compared to one incident during 1994-2010) and the geographic clustering in southeast QLD and northern NSW (30 incidents in southeast QLD and north NSW compared to 16 incidents in central and northern QLD...
Source: International Journal of Infectious Diseases - January 31, 2019 Category: Infectious Diseases Authors: N.Y.-H. Kung Tags: 03.013 Source Type: research

Unlocking High-Potential Non-Persistent Radical Chemistry for Semi-Aqueous Redox Batteries
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C8CC09304K, CommunicationYuheng Tian, Kuang-Hsu Wu, Liuyue Cao, Wibawa Hendra Saputera, Rose Amal, Dawei Wang A non-persistent radical precursor, N-hydroxyphthalimide (NHPI), is reported as a low-cost, high-potential organic cathode in a binary electrolyte for a semi-aqueous redox battery. A highly reversible NHPI-phthalimide N-oxyl (PINO) radical... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - January 30, 2019 Category: Chemistry Authors: Yuheng Tian Source Type: research