GSE234214 The Sequence Basis for Selectivity of Ephrin-B2 for Eph Receptors and Pathogenic Henipavirus G Glycoproteins [EFNB2-D62Q DEEP MUTAGENESIS]
Contributor : Erik ProckoSeries Type : OtherOrganism : Homo sapiensEphrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and also functions as a cell entry receptor for several henipaviruses, which are zoonotic viruses with pandemic potential. Two such viruses, Nipah (NiV) and Hendra (HeV), are highly pathogenic in humans yet do not have any widely approved virus-specific therapeutics or vaccines. Soluble Fc-fusions of EFNB2 (sEFNB2-Fc) are known to bind the attachment glycoprotein G of both viruses and inhibit viral infection of cells. However, the potential of sEFNB2-Fc as a neutralizing agent in vivo is hindere...
Source: GEO: Gene Expression Omnibus - June 12, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Effects of mobile phone electromagnetic radiation on thyroid glands and hormones in < em > Rattus norvegicus < /em > brain: An analysis of thyroid function, reactive oxygen species, and monocarboxylate transporter 8
In conclusion, a significant reduction in TSH, T4, and MCT8 levels indicated thyroid dysfunction due to MP-EMR exposure.PMID:37255871 | PMC:PMC10226703 | DOI:10.4103/japtr.japtr_680_22 (Source: Adv Data)
Source: Adv Data - May 31, 2023 Category: Epidemiology Authors: Hendra Zufry Achmad Rudijanto Djoko Wahono Soeatmadji Setyawan Purnomo Sakti Khairul Munadi Hidayat Sujuti Karyono Mintaroem Source Type: research
Viruses, Vol. 15, Pages 1302: Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism
her F. Basler
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the Henipavirus genus within the paramyxovirus family and are harbored by Pteropus Flying Fox species. Henipaviruses cause severe respiratory disease, neural symptoms, and encephalitis in various animals and humans, with human mortality rates exceeding 70% in some NiV outbreaks. The henipavirus matrix protein (M), which drives viral assembly and budding of the virion, also performs non-structural functions as a type I interferon antagonist. Interestingly, M also undergoes nuclear trafficking that mediates critical monoubiquitinati...
Source: Viruses - May 31, 2023 Category: Virology Authors: Camilla M. Donnelly Olivia A. Vogel Megan R. Edwards Paige E. Taylor Justin A. Roby Jade K. Forwood Christopher F. Basler Tags: Article Source Type: research
Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis
This study aimed to analyze the efficacy of stem cell-based tissue engineering for the treatment of alveolar cleft (AC) and cleft palate (CP) defects in animal models.Systematic review and meta-analysis.Preclinical studies on alveolar cleft repair in maxillofacial practice.Electronic search was performed using PubMed, Embase, and Cochrane databases. Pre-clinical studies, where stem cell-based tissue engineering was used in the reconstruction of AC and CP in animal models were included. Quality of the selected articles was evaluated using SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation).Review of alve...
Source: The Cleft Palate-Craniofacial Journal - May 19, 2023 Category: ENT & OMF Authors: Diandra S Natsir Kalla Salem A Alkaabi Faqi N Hendra Nisrina E Nasrun Muhammad Ruslin Tymour Forouzanfar Marco N Helder Source Type: research
Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis
This study aimed to analyze the efficacy of stem cell-based tissue engineering for the treatment of alveolar cleft (AC) and cleft palate (CP) defects in animal models.Systematic review and meta-analysis.Preclinical studies on alveolar cleft repair in maxillofacial practice.Electronic search was performed using PubMed, Embase, and Cochrane databases. Pre-clinical studies, where stem cell-based tissue engineering was used in the reconstruction of AC and CP in animal models were included. Quality of the selected articles was evaluated using SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation).Review of alve...
Source: The Cleft Palate-Craniofacial Journal - May 19, 2023 Category: ENT & OMF Authors: Diandra S Natsir Kalla Salem A Alkaabi Faqi N Hendra Nisrina E Nasrun Muhammad Ruslin Tymour Forouzanfar Marco N Helder Source Type: research
Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis
This study aimed to analyze the efficacy of stem cell-based tissue engineering for the treatment of alveolar cleft (AC) and cleft palate (CP) defects in animal models.Systematic review and meta-analysis.Preclinical studies on alveolar cleft repair in maxillofacial practice.Electronic search was performed using PubMed, Embase, and Cochrane databases. Pre-clinical studies, where stem cell-based tissue engineering was used in the reconstruction of AC and CP in animal models were included. Quality of the selected articles was evaluated using SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation).Review of alve...
Source: The Cleft Palate-Craniofacial Journal - May 19, 2023 Category: ENT & OMF Authors: Diandra S Natsir Kalla Salem A Alkaabi Faqi N Hendra Nisrina E Nasrun Muhammad Ruslin Tymour Forouzanfar Marco N Helder Source Type: research
In silico Study of Antiviral Activity of Polyphenol Compounds from < em > Ocimum basilicum < /em > by Molecular Docking, ADMET, and Drug-Likeness Analysis
CONCLUSION: Based on the data obtained, Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside are compounds that have more potential to have an antiviral effect on the main protease enzyme than aesculetin. Based on pharmacokinetic parameters and drug-likeness, three compounds can be used as lead compounds for further research.PMID:37131997 | PMC:PMC10149097 | DOI:10.2147/AABC.S403175 (Source: Adv Data)
Source: Adv Data - May 3, 2023 Category: Epidemiology Authors: Dikdik Kurnia Salsabila Aqila Putri Sefren Geiner Tumilaar Achmad Zainuddin Hendra Dian Adhita Dharsono Meiny Faudah Amin Source Type: research
In silico Study of Antiviral Activity of Polyphenol Compounds from < em > Ocimum basilicum < /em > by Molecular Docking, ADMET, and Drug-Likeness Analysis
CONCLUSION: Based on the data obtained, Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside are compounds that have more potential to have an antiviral effect on the main protease enzyme than aesculetin. Based on pharmacokinetic parameters and drug-likeness, three compounds can be used as lead compounds for further research.PMID:37131997 | PMC:PMC10149097 | DOI:10.2147/AABC.S403175 (Source: Adv Data)
Source: Adv Data - May 3, 2023 Category: Epidemiology Authors: Dikdik Kurnia Salsabila Aqila Putri Sefren Geiner Tumilaar Achmad Zainuddin Hendra Dian Adhita Dharsono Meiny Faudah Amin Source Type: research
Viruses, Vol. 15, Pages 1077: A Recombinant Chimeric Cedar Virus-Based Surrogate Neutralization Assay Platform for Pathogenic Henipaviruses
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Christopher C. Broder
The henipaviruses, Nipah virus (NiV), and Hendra virus (HeV) can cause fatal diseases in humans and animals, whereas Cedar virus is a nonpathogenic henipavirus. Here, using a recombinant Cedar virus (rCedV) reverse genetics platform, the fusion (F) and attachment (G) glycoprotein genes of rCedV were replaced with those of NiV-Bangladesh (NiV-B) or HeV, generating replication-competent chimeric viruses (rCedV-NiV-B and rCedV-HeV), both with and without green fluorescent protein (GFP) or luciferase protein genes. The rCedV chimeras induced a Type I interferon response and utilized only ephrin-B2...
Source: Viruses - April 28, 2023 Category: Virology Authors: Moushimi Amaya Randy Yin Lianying Yan Viktoriya Borisevich Bishwo N. Adhikari Andrew Bennett Francisco Malagon Regina Z. Cer Kimberly A. Bishop-Lilly Antony S. Dimitrov Robert W. Cross Thomas W. Geisbert Christopher C. Broder Tags: Article Source Type: research
Successful treatment of anogenital warts with single dose Bacillus Calmette Guerin vaccine without prior sensitization in tuberculosis endemic country: Two case report
. (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 21, 2023 Category: Allergy & Immunology Authors: Pati Aji Achdiat Oki Suwarsa Yudi Mulyana Hidayat Mohamad Nasir Shafiee Reiva Farah Dwiyana Hendra Gunawan Rasmia Rowawi Reyshiani Johan Source Type: research
Successful treatment of anogenital warts with single dose Bacillus Calmette Guerin vaccine without prior sensitization in tuberculosis endemic country: Two case report
Volume 19, Issue 1, December 2023 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 21, 2023 Category: Allergy & Immunology Authors: Pati Aji Achdiat Oki Suwarsa Yudi Mulyana Hidayat Mohamad Nasir Shafiee Reiva Farah Dwiyana Hendra Gunawan Rasmia Rowawi Reyshiani Johan Source Type: research
Pseudotyped Virus for Henipavirus
Adv Exp Med Biol. 2023;1407:175-190. doi: 10.1007/978-981-99-0113-5_9.ABSTRACTThe genus Henipavirus (HNV) includes two virulent infectious viruses, Nipah virus (NiV) and Hendra virus (HeV), which are the focus of considerable public health research efforts and have been classified as priority infectious diseases by the World Health Organization. Both viruses are high risk and should be handled in biosafety level 4 laboratories. Pseudotyped viruses containing the envelope proteins of HNV viruses have the same envelope protein structure as the authentic viruses; thus, they can mimic the receptor-binding and membrane fusion p...
Source: Advances in Experimental Medicine and Biology - March 15, 2023 Category: Research Authors: Tao Li Ziteng Liang Weijin Huang Youchun Wang Source Type: research
Sensors, Vol. 23, Pages 2965: Design Consideration, Numerical and Experimental Analyses of Mode-Division-Multiplexed (MDM) Silicon Photonics Integrated Circuit with Sharp Bends
iu
Chien-Hung Yeh
Due to the popularity of different high bandwidth applications, it is becoming increasingly difficult to satisfy the huge data capacity requirements, since the traditional electrical interconnects suffer significantly from limited bandwidth and huge power consumption. Silicon photonics (SiPh) is one of the important technologies for increasing interconnect capacity and decreasing power consumption. Mode-division multiplexing (MDM) allows signals to be transmitted simultaneously, at different modes, in a single waveguide. Wavelength-division multiplexing (WDM), non-orthogonal multiple access (NOMA) a...
Source: Sensors - March 9, 2023 Category: Biotechnology Authors: Pin-Cheng Kuo Chi-Wai Chow Yuan-Zeng Lin Wahyu Hendra Gunawan Tun-Yao Hung Yin-He Jian Guan-Hong Chen Ching-Wei Peng Yang Liu Chien-Hung Yeh Tags: Article Source Type: research
Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients
CONCLUSION: There is significantly increased expression of TLR2 and TLR6 on peripheral blood monocytes induced by SEB during exacerbation in AD patients.PMID:36748066 | PMC:PMC9899008 | DOI:10.2147/CCID.S401815 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 7, 2023 Category: Dermatology Authors: Fitria Salim Hendra Gunawan Oki Suwarsa Endang Sutedja Source Type: research
