Structural Modeling of Adaptive Immune Responses to Infection

We present a method for high-throughput structural modeling of antibodies or TCRs using Repertoire Builder and its extensions. AbAdapt is an extension of Repertoire Builder for antibody-antigen docking from antibody and antigen sequences. ImmuneScape is a corresponding extension for TCR-pMHC 3D modeling. Together, these pipelines can help researchers to understand immune responses to infection from a structural point of view.PMID:36346598 | DOI:10.1007/978-1-0716-2609-2_15

Source: Mol Biol Cell - November 8, 2022 Category: Molecular Biology Authors: Tina Lusiany Zichang Xu Dianita S Saputri Hendra S Ismanto Sedat Aybars Nazlica Daron M Standley Source Type: research