Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research
Pregnancy outcomes in Chinese women with mechanical heart valves receiving warfarin treatment throughout pregnancy: 14-year experience
The purpose was to evaluate pregnancy outcomes and risk factors associated with fetal complications in Chinese pregnant women with mechanical heart valves (MHVs) taking low-dose warfarin, aiming to fill in the research gap of this area. (Source: Thrombosis Research)
Source: Thrombosis Research - February 15, 2024 Category: Hematology Authors: Tianyu Li, Lei Chen, Mei Peng, Guobao Song, Chunyan Wang, Qiyun Peng, Shenglan Tan Tags: Full Length Article Source Type: research
Impact of Adding Early Bedside Cycling to Inpatient Cardiac Rehabilitation on Physical Function and Length of Stay after Heart Valve Surgery. A Randomized Controlled Trial
Heart valve replacement surgery is a well-established treatment for severe valvular heart disease.1 After heart valve surgery, there is an improvement in hemodynamic parameters; however, the functional capacity remains sub-optimal due to physical inactivity and deconditioning.2,3 Hypoventilation and reduced lung volumes following surgery further reduce physical capacity and increase the length of hospital stays.4 Prolonged ICU stay is associated with lower survival rates, increased hospital costs, and reduced ICU bed availability. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - February 15, 2024 Category: Rehabilitation Authors: Ahmad Mahdi Ahmad, Salwa Asem Abusarea, Bassem Zarif Fouad, Sandra Aziz Guirguis, Wael Abdel Shafie Tags: Original Research Source Type: research
Effect of Adding Early Bedside Cycling to Inpatient Cardiac Rehabilitation on Physical Function and Length of Stay After Heart Valve Surgery: A Randomized Controlled Trial
Heart valve replacement surgery is a well-established treatment for severe valvular heart disease.1 After heart valve surgery, there is an improvement in hemodynamic parameters; however, the functional capacity remains sub-optimal due to physical inactivity and deconditioning.2,3 Hypoventilation and reduced lung volumes after surgery further reduce physical capacity and increase the length of hospital stays.4 Prolonged intensive care unit (ICU) stay is associated with lower survival rates, increased hospital costs, and reduced ICU bed availability. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - February 15, 2024 Category: Rehabilitation Authors: Ahmad Mahdi Ahmad, Salwa Asem Abusarea, Bassem Zarif Fouad, Sandra Aziz Guirguis, Wael Abdel Shafie Tags: ORIGINAL RESEARCH Source Type: research
Immune response following transcatheter aortic valve procedure
Vascul Pharmacol. 2024 Feb 9;154:107283. doi: 10.1016/j.vph.2024.107283. Online ahead of print.ABSTRACTAortic valve stenosis is the most common type of heart valve disease in the United States and Europe and calcific aortic stenosis (AS) affects 2-7% of people aged 65 years and older. Aortic valve replacement (AVR) is the only effective treatment for individuals with this condition. Transcatheter Aortic Valve Replacement (TAVR) has been widely accepted as a minimally invasive therapeutic approach for addressing symptomatic AS in patients who are considered to have a high risk for traditional surgical intervention. TAVR pro...
Source: Vascular Pharmacology - February 10, 2024 Category: Drugs & Pharmacology Authors: Kasra Talebi Anaraki Zahra Zahed Roozbeh Narimani Javid Sasan Shafiei Fereshteh Beiranvandi Negin Ghasemi Kahrizsangi Faraz Golafshan Alireza Arzhangzade Javad Kojuri Samin Almassian Raha Hadi Pourya Gholizadeh Fahimeh Kazeminava Source Type: research
Mitral Valve Segmentation and Tracking from Transthoracic Echocardiography Using Deep Learning
Valvular heart diseases (VHDs) pose a significant public health burden, and deciding the best treatment strategy necessitates accurate assessment of heart valve function. Transthoracic echocardiography (TTE) is the key modality to evaluate VHDs, but the lack of standardized quantitative measurements leads to subjective and time-consuming assessments. We aimed to use deep learning to automate the extraction of mitral valve (MV) leaflets and annular hinge points from echocardiograms of the MV, improving standardization and reducing workload in quantitative assessment of MV disease. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 9, 2024 Category: Radiology Authors: Sigurd Vangen Wifstad, Henrik Agerup Kildahl, Bj ørnar Grenne, Espen Holte, Ståle Wågen Hauge, Sigbjørn Sæbø, Desalew Mekonnen, Berhanu Nega, Rune Haaverstad, Mette-Elise Estensen, Håvard Dalen, Lasse Lovstakken Tags: Original Contribution Source Type: research
Predictive Role of Preoperative Nutritional Status on Early Postoperative Outcomes in Different-Aged Patients Undergoing Heart Valve Surgery
INSUFFICIENT NUTRIENT intake, culminating in malnutrition, represents a complex syndrome that fails to fulfill the physiologic needs of patients. This condition may further deteriorate due to systemic inflammatory responses triggered by underlying diseases.1 Preoperative malnutrition is closely linked to suboptimal early postoperative outcomes. Notably, early nutritional intervention is posited to enhance patient prognosis.2,3 Within the field of cardiovascular disease, preoperative malnutrition has been identified as a significant prognostic indicator for early postoperative outcomes, including prolonged intensive care un...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 6, 2024 Category: Anesthesiology Authors: Xuetao Jiang, Jie Xiang, Ming Yang, Wenjun Liu, Guoyun Lin, Fang Chen, Wei Wang, Guangyou Duan, Sheng Jing, Xiaohang Bao Tags: Original Article Source Type: research
GSE254394 Exploring Genes Regulated by circHIPK3 in Aortic Valve Interstitial Cells
Contributors : Gaopeng Xian ; Qingchun Zeng ; Rong Huang ; Dingli XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAortic valve calcific disease (CAVD) is a common heart valve condition typically characterized by severe narrowing of the aortic valve. Our previous research has shown that circHIPK3 is downregulated in calcified aortic valve tissues and plays a role in regulating the progression of CAVD. To further investigate how circHIPK3 exerts its inhibitory effects on aortic valve calcification, we overexpressed circHIPK3 in aortic valve interstitial cells and conducted RNA-seq...
Source: GEO: Gene Expression Omnibus - February 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE254393 Exploring the expression pattern of circRNA in the aortic valve
This study reports the expression profile of circRNAs in the aortic valve tissues of CAVD patients and a normal control group (non-CAVD). We collected aortic valve tissue samples from three CAVD patients who underwent aortic valve replacement surgery due to severe aortic valve stenosis, as well as aortic valve samples from non-CAVD patients who either received heart transplant surgery (recipient heart) or had their aortic valve removed due to aortic dissection. Overall, our research reveals the significant role of circRNAs in the progression of CAVD. CircRNAs, a class of circular non-coding RNA molecules, are actively stud...
Source: GEO: Gene Expression Omnibus - February 2, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Navigating The Challenges of Redo-Transcatheter Aortic Valve Replacement: Predicting Sinus Sequestration and Coronary Obstruction in The Era Of Expanding Treatment
The positive results of low-risk randomized trials have led to an increasing number of younger patients diagnosed with severe symptomatic aortic stenosis being treated with transcatheter aortic valve replacement (TAVR).1 Many of these subjects at less risk are expected to have a longer life expectancy, and a possible need for future reintervention due to bioprosthesis valve failure. The TAVR-in-TAVR procedure appears to be safer than TAVR-explant for treating structural degeneration of transcatheter heart valves (THV). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2024 Category: Cardiology Authors: Giuseppe Tarantini, Francesco Cardaioli Tags: Editorial Source Type: research
Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves
The defects of bioprosthetic heart valves (BHVs) such as thrombosis, structural valve degeneration, calcification, insufficient re-internalization, and inflammatory response have affected their biocompatibility and longevity. The strategies of surface modification with natural polymeric materials, hydrophilic antifouling polymers, bioactive molecules, and nanodrug delivery systems can be a promising way to improve BHVs. AbstractValvular heart disease (VHD) has become a burden and a growing public health problem in humans, causing significant morbidity and mortality worldwide. An increasing number of patients with severe VH...
Source: Small - January 27, 2024 Category: Nanotechnology Authors: Qi Tong,
Jie Cai,
Zhengjie Wang,
Yiren Sun,
Xuyue Liang,
Qiyue Xu,
Oumar Abdel Mahamoud,
Yongjun Qian,
Zhiyong Qian Tags: Review Source Type: research
Somatic < em > GATA4 < /em > mutation contributes to tetralogy of Fallot
Exp Ther Med. 2024 Jan 8;27(2):91. doi: 10.3892/etm.2024.12379. eCollection 2024 Feb.ABSTRACTTetralogy of Fallot (TOF) is the most prevalent cyanotic congenital heart pathology and causes infant morbidity and mortality worldwide. GATA-binding protein 4 (GATA4) serves as a pivotal transcriptional factor for embryonic cardiogenesis and germline GATA4 mutations are causally linked to TOF. However, the effects of somatic GATA4 mutations on the pathogenesis of TOF remain to be ascertained. In the present study, sequencing assay of GATA4 was performed utilizing genomic DNA derived from resected heart tissue specimens as well as ...
Source: Experimental and Therapeutic Medicine - January 26, 2024 Category: General Medicine Authors: Pradhan Abhinav Yan-Jie Li Ri-Tai Huang Xing-Yuan Liu Jia-Ning Gu Chen-Xi Yang Ying-Jia Xu Juan Wang Yi-Qing Yang Source Type: research
Prevalence of Guideline Discordant Aspirin use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement
Antithrombotic therapy guidelines change over time due to evolving research and available treatments. For concomitant aspirin in patients on vitamin K antagonists for ischemic stroke prevention in mechanical heart valves, guidelines have shifted. In 2020, citing the fact that previous studies included many patients with older-generation valve prostheses and acknowledging the increased risk of major bleeding, the American College of Cardiology (ACC) and American Heart Association (AHA) reversed their previous recommendations to routinely add aspirin to VKA therapy. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - January 25, 2024 Category: General Medicine Authors: Brian Haymart, Xiaowen Kong, Mona Ali, Jordan K. Schaefer, James B. Froehlich, Noelle Ryan, Beverly Stallings, Geoffrey D. Barnes, Scott Kaatz Tags: Clinical Research Study Source Type: research
Prevalence of Guideline-Discordant Aspirin Use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement
For patients on warfarin for mechanical heart valve replacement, the 2020 American College of Cardiology and American Heart Association Guidelines recommend only adding aspirin in patients with a specific indication for antiplatelet therapy. This contrasts with prior guidelines, which recommended concomitant aspirin therapy. We sought to assess the prevalence of guideline-discordant aspirin use among patients on warfarin for mechanical heart valve replacement and to compare adverse event rates among patients with and without concomitant aspirin. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - January 25, 2024 Category: General Medicine Authors: Brian Haymart, Xiaowen Kong, Mona Ali, Jordan K. Schaefer, James B. Froehlich, Noelle Ryan, Beverly Stallings, Geoffrey D. Barnes, Scott Kaatz Tags: Clinical Research Study Source Type: research
