A synergistic strategy based on active hydroxymethyl amine compounds and fucoidan for bioprosthetic heart valves with enhancing anti-coagulation and anti-calcification properties
Int J Biol Macromol. 2024 Mar 8:130715. doi: 10.1016/j.ijbiomac.2024.130715. Online ahead of print.ABSTRACTWith an aging population, the patients with valvular heart disease (VHD) are growing worldwide, and valve replacement is a primary choice for these patients with severe valvular disease. Among them, bioprosthetic heart valves (BHVs), especially BHVs trough transcatheter aortic valve replacement, are widely accepted by patients on account of their good hemodynamics and biocompatibility. Commercial BHVs in clinic are prepared by glutaraldehyde cross-linked pericardial tissue with the risk of calcification and thrombotic...
Source: International Journal of Biological Macromolecules - March 10, 2024 Category: Biochemistry Authors: Hongxia Pu Canyu Wang Tao Yu Xiaotong Chen Gaocan Li Da Zhu Xiangbin Pan Yunbing Wang Source Type: research
A synergistic strategy based on active hydroxymethyl amine compounds and fucoidan for bioprosthetic heart valves with enhancing anti-coagulation and anti-calcification properties
Int J Biol Macromol. 2024 Mar 8:130715. doi: 10.1016/j.ijbiomac.2024.130715. Online ahead of print.ABSTRACTWith an aging population, the patients with valvular heart disease (VHD) are growing worldwide, and valve replacement is a primary choice for these patients with severe valvular disease. Among them, bioprosthetic heart valves (BHVs), especially BHVs trough transcatheter aortic valve replacement, are widely accepted by patients on account of their good hemodynamics and biocompatibility. Commercial BHVs in clinic are prepared by glutaraldehyde cross-linked pericardial tissue with the risk of calcification and thrombotic...
Source: International Journal of Biological Macromolecules - March 10, 2024 Category: Biochemistry Authors: Hongxia Pu Canyu Wang Tao Yu Xiaotong Chen Gaocan Li Da Zhu Xiangbin Pan Yunbing Wang Source Type: research
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery
CONCLUSION: The genotypes of CYP2C9, VKORC1, and GGCX were found to have a significant impact on INR variability during the initial phase of warfarin therapy. However, no significant association was observed between TTR and gene polymorphisms. These findings suggest that focusing on INR variability is crucial in clinical practice, and preoperative detection of gene polymorphisms should be considered to assist in the initiation of warfarin therapy.PMID:38457019 | DOI:10.1007/s43440-024-00575-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 8, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Liu Fengming Luo Juan Zhao Weinan Chen Wei Gao Zhou Zhou Source Type: research
A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlat...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Yevgeniy Kreinin Yahel Talmon Moran Levi Maria Khoury Itay Or Mahli Raad Gil Bolotin Josu é Sznitman Netanel Korin Source Type: research
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery
CONCLUSION: The genotypes of CYP2C9, VKORC1, and GGCX were found to have a significant impact on INR variability during the initial phase of warfarin therapy. However, no significant association was observed between TTR and gene polymorphisms. These findings suggest that focusing on INR variability is crucial in clinical practice, and preoperative detection of gene polymorphisms should be considered to assist in the initiation of warfarin therapy.PMID:38457019 | DOI:10.1007/s43440-024-00575-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 8, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Liu Fengming Luo Juan Zhao Weinan Chen Wei Gao Zhou Zhou Source Type: research
A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlat...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Yevgeniy Kreinin Yahel Talmon Moran Levi Maria Khoury Itay Or Mahli Raad Gil Bolotin Josu é Sznitman Netanel Korin Source Type: research
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery
CONCLUSION: The genotypes of CYP2C9, VKORC1, and GGCX were found to have a significant impact on INR variability during the initial phase of warfarin therapy. However, no significant association was observed between TTR and gene polymorphisms. These findings suggest that focusing on INR variability is crucial in clinical practice, and preoperative detection of gene polymorphisms should be considered to assist in the initiation of warfarin therapy.PMID:38457019 | DOI:10.1007/s43440-024-00575-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 8, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Liu Fengming Luo Juan Zhao Weinan Chen Wei Gao Zhou Zhou Source Type: research
A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlat...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Yevgeniy Kreinin Yahel Talmon Moran Levi Maria Khoury Itay Or Mahli Raad Gil Bolotin Josu é Sznitman Netanel Korin Source Type: research
