Prevalence of Guideline Discordant Aspirin use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement
Antithrombotic therapy guidelines change over time due to evolving research and available treatments. For concomitant aspirin in patients on vitamin K antagonists for ischemic stroke prevention in mechanical heart valves, guidelines have shifted. In 2020, citing the fact that previous studies included many patients with older-generation valve prostheses and acknowledging the increased risk of major bleeding, the American College of Cardiology (ACC) and American Heart Association (AHA) reversed their previous recommendations to routinely add aspirin to VKA therapy. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - January 25, 2024 Category: General Medicine Authors: Brian Haymart, Xiaowen Kong, Mona Ali, Jordan K. Schaefer, James B. Froehlich, Noelle Ryan, Beverly Stallings, Geoffrey D. Barnes, Scott Kaatz Tags: Clinical Research Study Source Type: research
Prevalence of Guideline-Discordant Aspirin Use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement
For patients on warfarin for mechanical heart valve replacement, the 2020 American College of Cardiology and American Heart Association Guidelines recommend only adding aspirin in patients with a specific indication for antiplatelet therapy. This contrasts with prior guidelines, which recommended concomitant aspirin therapy. We sought to assess the prevalence of guideline-discordant aspirin use among patients on warfarin for mechanical heart valve replacement and to compare adverse event rates among patients with and without concomitant aspirin. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - January 25, 2024 Category: General Medicine Authors: Brian Haymart, Xiaowen Kong, Mona Ali, Jordan K. Schaefer, James B. Froehlich, Noelle Ryan, Beverly Stallings, Geoffrey D. Barnes, Scott Kaatz Tags: Clinical Research Study Source Type: research
The “fender” technique for redo-TAVR in a degenerated supra-annular valve with high-risk of coronary obstruction
A 77-year-old woman affected by diabetes mellitus and end-stage kidney disease on dialysis was admitted to our department for congestive heart failure and evidence of structural deterioration (1) of an Acurate Neo S (Boston Scientifics) aortic transcatheter heart valve (THV) implanted 4 years prior. At transthoracic echocardiography, sclerotic degeneration of THV's leaflets with significant increase in valve gradients (mean gradient 45 mmHg, valve area 0.97 cm2) and mild central aortic regurgitation was observed (Figure 1, Panel A-B). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 24, 2024 Category: Cardiology Authors: Giuseppe Tarantini, Tommaso Fabris, Subhash Banerjee, Luca Nai Fovino Tags: Brief report Source Type: research
Multicentre, open-label, randomised, controlled trial to compare early intervention with calcimimetics and conventional therapy in preventing coronary artery calcification in patients with secondary hyperparathyroidism (UPCOMING): a study protocol
Introduction
Coronary artery and heart valve calcification is a risk factor for cardiovascular death in haemodialysis patients, so calcification prevention should be started as early as possible. Treatment with concomitant calcimimetics and low-dose vitamin D receptor activators (VDRAs) is available, but not enough evidence has been obtained on the efficacy of this regimen, particularly in patients with short dialysis duration. Therefore, this study will evaluate the efficacy and safety of early intervention with upacicalcet, a calcimimetic used to prevent coronary artery calcification in this patient population.
Methods ...
Source: BMJ Open - January 24, 2024 Category: General Medicine Authors: Inaguma, D., Tatematsu, Y., Okamoto, N., Ogata, S., Kawai, H., Watanabe, E., Yuzawa, Y., Hasegawa, M., Tsuboi, N. Tags: Open access, Renal medicine Source Type: research
The “Fender” Technique for Redo-TAVR in a Degenerated Supra-Annular Valve With High Risk of Coronary Obstruction
A 77-year-old woman affected by diabetes mellitus and end-stage kidney disease on dialysis was admitted to our department for congestive heart failure and evidence of structural deterioration1 of an Acurate Neo S (Boston Scientific) aortic transcatheter heart valve (THV) implanted 4 years previously. At transthoracic echocardiography, sclerotic degeneration of THV leaflets with a significant increase in valve gradients (mean gradient 45 mm Hg, valve area 0.97 cm2) and mild central aortic regurgitation were observed (Figure 1). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 24, 2024 Category: Cardiology Authors: Giuseppe Tarantini, Tommaso Fabris, Subhash Banerjee, Luca Nai Fovino Tags: Editorial Source Type: research
Partial Heart Transplantation - How to Change the System
Partial heart transplantation is the first clinically successful approach to deliver growing heart valve implants. To date, 13 clinical partial heart transplants have been performed. However, turning partial heart transplantation into a routine procedure that is available to all children who would benefit from growing heart valve implants poses formidable logistical challenges. Firstly, a supply for partial heart transplant donor grafts needs to be developed. This challenge is complicated by the scarcity of donor organs. (Source: Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual)
Source: Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual - January 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Douglas M. Overbey, Taufiek K. Rajab, Joseph W. Turek Tags: Invited Expert Review Source Type: research
Partial heart transplantation: a new option for paediatric heart valve replacement
Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00991-6Heart valve replacement in newborn babies remains an unsolved problem because currently used heart valve implants do not grow. This lack of implant growth mandates serial re-operations until adult-size valve implants can be fitted. Partial heart transplantation is a new approach to solve this problem by transplanting only the part of the heart that contains the necessary valve. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 23, 2024 Category: Cardiology Authors: Taufiek K. Rajab Andrew D. Vogel Joseph W. Turek Source Type: research
Clinical Outcomes Following Transcatheter Mitral Valve-in-Valve Replacement Using a Meril Myval Transcatheter Heart Valve
This study aimed to report in-hospital, 30-day, and 1-year outcomes of Myval patients who underwent TMViV in a single tertiary care centre in India. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 19, 2024 Category: Cardiology Authors: Mullasari Ajit Sankardas, Vijayakumar Subban, Sivakumar Kothandam, Aashish Chopra, Latchumanadhas Kalidoss, Kalaichelvan Udhayakumar, Ramkumar Sollimuthu, Kumar Chidambaram, Harini Anandan, Ravinder Singh Rao Tags: Original Article Source Type: research
3D printing of heart valves
Trends Biotechnol. 2024 Jan 17:S0167-7799(23)00323-2. doi: 10.1016/j.tibtech.2023.11.001. Online ahead of print.ABSTRACT3D printing technologies have the potential to revolutionize the manufacture of heart valves through the ability to create bespoke, complex constructs. In light of recent technological advances, we review the progress made towards 3D printing of heart valves, focusing on studies that have utilised these technologies beyond manufacturing patient-specific moulds. We first overview the key requirements of a heart valve to assess functionality. We then present the 3D printing technologies used to engineer hea...
Source: Trends in Biotechnology - January 18, 2024 Category: Biotechnology Authors: Michael J Vernon Petra Mela Rodney J Dilley Shirley Jansen Barry J Doyle Abdul R Ihdayhid Elena M De-Juan-Pardo Source Type: research
How to evacuate when Sapien3 transcatheter heart valve cannot pass through a severely calcified aortic valve
(Source: Cardiovascular Intervention and Therapeutics)
Source: Cardiovascular Intervention and Therapeutics - January 16, 2024 Category: Cardiology Source Type: research
Impact of transcatheter heart valve type on outcomes of surgical explantation after failed transcatheter aortic valve replacement: the EXPLANT-TAVR international registry
CONCLUSIONS: In the EXPLANT-TAVR global registry, BEV and SEV groups had different indications for surgical explantation, with more root replacements in SEV failure, but no differences in midterm mortality and morbidities. Further refinement of TAVR explantation techniques are important to improving outcomes.PMID:38224255 | PMC:PMC10786178 | DOI:10.4244/EIJ-D-23-00722 (Source: EuroIntervention)
Source: EuroIntervention - January 15, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Syed Zaid Neal S Kleiman Sachin S Goel Molly I Szerlip Michael J Mack Mateo Marin-Cuartas Siamak Mohammadi Tamim M Nazif Axel Unbehaun Martin Andreas Derek R Brinster Newell B Robinson Lin Wang Basel Ramlawi Lenard Conradi Nimesh D Desai John K Forrest Ro Source Type: research
Outcomes of Valve-In-Valve Transcatheter Aortic Valve Replacement
Structural valve degeneration (SVD) is increasingly seen given the higher rates of bioprosthetic heart valve (BHV) usage for surgical and transcatheter aortic valve replacement (TAVR). Valve-in-valve TAVR (VIV-TAVR) is an attractive alternate for patients who are otherwise at high risk for reoperative surgery. We compared patients undergoing VIV-TAVR and native-valve TAVR through a retrospective analysis of our institutional TVT database from 2013 to 2022. Patients undergoing either a native-valve TAVR or VIV-TAVR were included. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 15, 2024 Category: Cardiology Authors: Danial Ahmad, Sarah Yousef, Dustin Kliner, James A. Brown, Derek Serna-Gallegos, Catalin Toma, Amber Makani, David West, Yisi Wang, Floyd W. Thoma, Ibrahim Sultan Source Type: research
Bacterial cellulose as a promising material for pulmonary valve prostheses: In vivo study in a sheep model
ConclusionsThis pilot study provides evidence that bacterial cellulose may be suitable for pulmonary valve prostheses and surgical pulmonary artery plasty. Further studies on the high pressure side of the left heart are needed. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - January 14, 2024 Category: Materials Science Authors: Piotr Siondalski,
Magdalena Ko łaczkowska,
Michał Bieńkowski,
Rafał Pęksa,
Maciej M. Kowalik,
Kinga Dawidowska,
Katrien Vandendriessche,
Bart Meuris Tags: RESEARCH ARTICLE Source Type: research
Transcatheter aortic valve implantation using coplanar and cuspal overlap techniques in Indian patients
CONCLUSION: In this study we achieved lower rates of PPI and new onset LBBB using COT technique in Indian patients using self-expandable prostheses. However valve deployment time, stroke rate and pericardial effusion were seen more in COT group. All cause mortality was low in cuspal overlap technique.PMID:38218314 | DOI:10.1016/j.ihj.2024.01.007 (Source: Indian Heart J)
Source: Indian Heart J - January 13, 2024 Category: Cardiology Authors: Rajat Datta Prashant Bharadwaj G Keshavamurthy Vivek Singh Guleria Ratheesh Kj Anil Kumar Abbot Source Type: research
Biofilm-producing antibiotic-resistant bacteria in Indian patients: a comprehensive review
Curr Med Res Opin. 2024 Jan 12:1-20. doi: 10.1080/03007995.2024.2305241. Online ahead of print.ABSTRACTFor the past few years, microbial biofilms have been emerging as a significant threat to the modern healthcare system, and their prevalence and antibiotic resistance threat gradually increase daily among the human population. The biofilm has a remarkable impact in the field of infectious diseases, in particular healthcare-associated infections related to indwelling devices such as catheters, implants, artificial heart valves, and prosthetic joints. Bacterial biofilm potentially adheres to any biotic or abiotic surfaces th...
Source: Current Medical Research and Opinion - January 12, 2024 Category: Research Authors: Susmita Datta Soma Nag Dijendra Nath Roy Source Type: research
