Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022
Antiviral Res. 2023 Jul 24:105679. doi: 10.1016/j.antiviral.2023.105679. Online ahead of print.ABSTRACTClade 2.3.4.4 b highly pathogenic avian influenza (HPAI) A (H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1015 sequences of HPAI A (H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-...
Source: Antiviral Research - July 26, 2023 Category: Virology Authors: Ha T Nguyen Anton Chesnokov Juan De La Cruz Philippe Noriel Q Pascua Vasiliy P Mishin Yunho Jang Joyce Jones Han Di Andrei A Ivashchenko Mary Lea Killian Mia K Torchetti Kristina Lantz David E Wentworth Charles T Davis Alexandre V Ivachtchenko Larisa V Gu Source Type: research
Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022
Antiviral Res. 2023 Jul 24:105679. doi: 10.1016/j.antiviral.2023.105679. Online ahead of print.ABSTRACTClade 2.3.4.4 b highly pathogenic avian influenza (HPAI) A (H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1015 sequences of HPAI A (H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-...
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Ha T Nguyen Anton Chesnokov Juan De La Cruz Philippe Noriel Q Pascua Vasiliy P Mishin Yunho Jang Joyce Jones Han Di Andrei A Ivashchenko Mary Lea Killian Mia K Torchetti Kristina Lantz David E Wentworth Charles T Davis Alexandre V Ivachtchenko Larisa V Gu Source Type: research
Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022
Antiviral Res. 2023 Jul 24:105679. doi: 10.1016/j.antiviral.2023.105679. Online ahead of print.ABSTRACTClade 2.3.4.4 b highly pathogenic avian influenza (HPAI) A (H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1015 sequences of HPAI A (H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-...
Source: Antiviral Research - July 26, 2023 Category: Virology Authors: Ha T Nguyen Anton Chesnokov Juan De La Cruz Philippe Noriel Q Pascua Vasiliy P Mishin Yunho Jang Joyce Jones Han Di Andrei A Ivashchenko Mary Lea Killian Mia K Torchetti Kristina Lantz David E Wentworth Charles T Davis Alexandre V Ivachtchenko Larisa V Gu Source Type: research
Avian Influenza Update
This Medical News article discusses the risk to humans from the currently circulating highly pathogenic avian influenza A(H5N1) virus. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - July 26, 2023 Category: General Medicine Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, Chile
Emerg Infect Dis. 2023 Jul 24;29(9). doi: 10.3201/eid2909.230067. Online ahead of print.ABSTRACTIn December 2022, highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus emerged in Chile. We detected H5N1 virus in 93 samples and obtained 9 whole-genome sequences of strains from wild birds. Phylogenetic analysis suggests multiple viral introductions into South America. Continued surveillance is needed to assess risks to humans and domestic poultry.PMID:37487166 | DOI:10.3201/eid2909.230067 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - July 24, 2023 Category: Infectious Diseases Authors: Naomi Ariyama Catalina Pardo-Roa Gabriela Mu ñoz Carolina Aguayo Claudia Ávila Christian Mathieu Leonardo I Almonacid Rafael A Medina Barbara Brito Magdalena Johow Victor Neira Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, Chile
N. Ariyama et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - July 24, 2023 Category: Infectious Diseases Source Type: research
Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments
The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances fromCetraria islandica lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potentin vitro antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log10, respectively, while the aqueous extract inhibited replication of...
Source: Bulletin of Experimental Biology and Medicine - July 19, 2023 Category: Biology Source Type: research
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo
Int Immunopharmacol. 2023 Jun 29;122:110544. doi: 10.1016/j.intimp.2023.110544. Online ahead of print.ABSTRACTInfluenza A virus is an important respiratory pathogen that poses serious threats to human health. Owing to the high mutation rate of viral genes, weaker cross-protection of vaccines, and rapid emergence of drug resistance, there is an urgent need to develop new antiviral drugs against influenza viruses. Taurocholic acid is a primary bile acid that promotes digestion, absorption, and excretion of dietary lipids. Here, we demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity a...
Source: International Immunopharmacology - July 1, 2023 Category: Allergy & Immunology Authors: Xiaolu Sun Xiaotong Hu Qiang Zhang Li Zhao Xiaomei Sun Li Yang Meilin Jin Source Type: research
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo
Int Immunopharmacol. 2023 Jun 29;122:110544. doi: 10.1016/j.intimp.2023.110544. Online ahead of print.ABSTRACTInfluenza A virus is an important respiratory pathogen that poses serious threats to human health. Owing to the high mutation rate of viral genes, weaker cross-protection of vaccines, and rapid emergence of drug resistance, there is an urgent need to develop new antiviral drugs against influenza viruses. Taurocholic acid is a primary bile acid that promotes digestion, absorption, and excretion of dietary lipids. Here, we demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity a...
Source: International Immunopharmacology - July 1, 2023 Category: Allergy & Immunology Authors: Xiaolu Sun Xiaotong Hu Qiang Zhang Li Zhao Xiaomei Sun Li Yang Meilin Jin Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Domestic Cat, France, 2022
Emerg Infect Dis. 2023 Jun 28;29(8). doi: 10.3201/eid2908.230188. Online ahead of print.ABSTRACTWe detected highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in a domestic cat that lived near a duck farm infected by a closely related virus in France during December 2022. Enhanced surveillance of symptomatic domestic carnivores in contact with infected birds is recommended to prevent further spread to mammals and humans.PMID:37379514 | DOI:10.3201/eid2908.230188 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 28, 2023 Category: Infectious Diseases Authors: Fran çois-Xavier Briand Florent Souchaud Isabelle Pierre V éronique Beven Edouard Hirchaud Fabrice H érault Ren é Planel Ang élina Rigaudeau Sibylle Bernard-Stoecklin Sylvie Van der Werf Bruno Lina Guillaume Gerbier Nicolas Eterradossi Audrey Schmitz Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Domestic Cat, France, 2022
Emerg Infect Dis. 2023 Jun 28;29(8). doi: 10.3201/eid2908.230188. Online ahead of print.ABSTRACTWe detected highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in a domestic cat that lived near a duck farm infected by a closely related virus in France during December 2022. Enhanced surveillance of symptomatic domestic carnivores in contact with infected birds is recommended to prevent further spread to mammals and humans.PMID:37379514 | DOI:10.3201/eid2908.230188 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 28, 2023 Category: Infectious Diseases Authors: Fran çois-Xavier Briand Florent Souchaud Isabelle Pierre V éronique Beven Edouard Hirchaud Fabrice H érault Ren é Planel Ang élina Rigaudeau Sibylle Bernard-Stoecklin Sylvie Van der Werf Bruno Lina Guillaume Gerbier Nicolas Eterradossi Audrey Schmitz Source Type: research
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Domestic Cat, France, 2022
F. Briand et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 26, 2023 Category: Infectious Diseases Source Type: research
Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021
Emerg Infect Dis. 2023 Jul;29(7):1367-1375. doi: 10.3201/eid2907.221149.ABSTRACTHighly pathogenic avian influenza (HPAI) subtype H5N1 clade 2.3.4.4b virus has spread globally, causing unprecedented large-scale avian influenza outbreaks since 2020. In 2021, we isolated 17 highly pathogenic avian influenza H5N1 viruses from wild birds in China. To determine virus origin, we genetically analyzed 1,529 clade 2.3.4.4b H5N1 viruses reported globally since October 2020 and found that they formed 35 genotypes. The 17 viruses belonged to genotypes G07, which originated from eastern Asia, and G10, which originated from Russia. The v...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jingman Tian Xiaoli Bai Minghui Li Xianying Zeng Jia Xu Peng Li Miao Wang Xingdong Song Zhiguo Zhao Guobin Tian Liling Liu Yuntao Guan Yanbing Li Hualan Chen Source Type: research
Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021
Emerg Infect Dis. 2023 Jul;29(7):1367-1375. doi: 10.3201/eid2907.221149.ABSTRACTHighly pathogenic avian influenza (HPAI) subtype H5N1 clade 2.3.4.4b virus has spread globally, causing unprecedented large-scale avian influenza outbreaks since 2020. In 2021, we isolated 17 highly pathogenic avian influenza H5N1 viruses from wild birds in China. To determine virus origin, we genetically analyzed 1,529 clade 2.3.4.4b H5N1 viruses reported globally since October 2020 and found that they formed 35 genotypes. The 17 viruses belonged to genotypes G07, which originated from eastern Asia, and G10, which originated from Russia. The v...
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Jingman Tian Xiaoli Bai Minghui Li Xianying Zeng Jia Xu Peng Li Miao Wang Xingdong Song Zhiguo Zhao Guobin Tian Liling Liu Yuntao Guan Yanbing Li Hualan Chen Source Type: research
Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b
Emerg Infect Dis. 2023 Jul;29(7):1492-1495. doi: 10.3201/eid2907.230296.ABSTRACTWe found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.PMID:37347930 | DOI:10.3201/eid2907.230296 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 22, 2023 Category: Infectious Diseases Authors: Annika Graaf Ronja Piesche Julia Sehl-Ewert Christian Grund Anne Pohlmann Martin Beer Timm Harder Source Type: research
