Isolation and genetic characterization of multiple genotypes of both H5 and H7 avian influenza viruses from environmental water in the Izumi plain, Kagoshima prefecture, Japan during the 2021/22 winter season
This study underscores the importance of monitoring both HPAIVs and LPAIVs to understand avian influenza virus ecology in migratory waterfowl populations.PMID:38640701 | DOI:10.1016/j.cimid.2024.102182 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - April 19, 2024 Category: Allergy & Immunology Authors: Kosuke Okuya Mana Esaki Kaori Tokorozaki Taichi Hasegawa Makoto Ozawa Source Type: research
Highly pathogenic avian influenza H5N1 virus infections of dairy cattle and livestock handlers in the United States of America
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - April 18, 2024 Category: Virology Authors: Hinh LyDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action?
epidemics, avian influenza, H5N1, highly pathogenic avian influenza, HPAI (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Eskild Petersen, Ziad A Memish, David S Hui, Alessandra Scagliarini, Lone Simonsen, Edgar Simulundu, Jennifer Bloodgood, Lucille Blumberg, Shui- Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research
Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors
Bioorg Med Chem Lett. 2024 Apr 10:129743. doi: 10.1016/j.bmcl.2024.129743. Online ahead of print.ABSTRACTNeuraminidase (NA) serves as a promising target for the exploration and development of anti-influenza drugs. In this work, lead compound 5 was discovered through pharmacophore-based virtual screening and molecular dynamics simulation, and 14 new compounds were obtained by modifying the lead compound 5 based on pharmacophore features. The biological activity test shows that 5n (IC50 = 0.13 μM) has a better inhibitory effect on wild-type NA (H5N1), while 5i (IC50 = 0.44 μM) has a prominent inhibitory effect on mutant NA...
Source: Bioorganic and Medicinal Chemistry Letters - April 12, 2024 Category: Chemistry Authors: Shi Kai Fu Li Ping Cheng Source Type: research
Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt
We examined the replication of kinetics of this virus in different mammalian cell lines (A549, MDCK, and Vero cells) and compared its pathogenicity to that of the ancestral H6N1 virus A/Quail/HK/421/2002(H6N1). The Egyptian H6N1 virus replicated efficiently in C57BL/6 mice without prior adaptation and grew faster and reached higher titers than in A549 cells than the ancestral strain. These results show that reassortant H6 AIVs might pose a potential threat to human health and highlight the need to continue surveillance of H6 AIVs circulating in nature. (Source: Archives of Virology)
Source: Archives of Virology - April 9, 2024 Category: Virology Source Type: research
Avian Influenza A (H5N1) Outbreak 2024 in Cambodia: Worries Over the Possible Spread of the Virus to Other Asian Nations and the Strategic Outlook for its Control
Environ Health Insights. 2024 Apr 6;18:11786302241246453. doi: 10.1177/11786302241246453. eCollection 2024.ABSTRACTAsia has been alarmed by the resurgence of avian influenza A (H5N1) in Cambodia in 2024. H5N1 could be swiftly transmitted by wild birds to poultry populations along their migration route via infection. Circulation of endemic H5N1 in Asian poultry facilitates recurrent human transmission. Cambodia's role as a reservoir heightens the potential dangers of uncoordinated containment and surveillance across Southeast Asia. This correspondence addresses the risk factors, seasonal patterns, transmission dynamics, and...
Source: Environmental Health Insights - April 8, 2024 Category: Environmental Health Authors: Farhana Yesmin Nidra Mayesha Bintey Monir Syed Masudur Rahman Dewan Source Type: research
Avian Influenza A (H5N1) Outbreak 2024 in Cambodia: Worries Over the Possible Spread of the Virus to Other Asian Nations and the Strategic Outlook for its Control
Environ Health Insights. 2024 Apr 6;18:11786302241246453. doi: 10.1177/11786302241246453. eCollection 2024.ABSTRACTAsia has been alarmed by the resurgence of avian influenza A (H5N1) in Cambodia in 2024. H5N1 could be swiftly transmitted by wild birds to poultry populations along their migration route via infection. Circulation of endemic H5N1 in Asian poultry facilitates recurrent human transmission. Cambodia's role as a reservoir heightens the potential dangers of uncoordinated containment and surveillance across Southeast Asia. This correspondence addresses the risk factors, seasonal patterns, transmission dynamics, and...
Source: Environmental Health Insights - April 8, 2024 Category: Environmental Health Authors: Farhana Yesmin Nidra Mayesha Bintey Monir Syed Masudur Rahman Dewan Source Type: research
Bird flu may be spreading in cows via milking and herd transport
The bird flu virus spreading through dairy cattle in the United States may be expanding its reach via milking equipment, the people doing the milking, or both U.S. Department of Agriculture (USDA) representatives reported today at an international, virtual meeting held to update the situation.
The avian virus may not be spreading directly from cows breathing on cows, as some researchers have speculated, according to USDA scientists who took part in the meeting organized jointly by the World Organisation for Animal Health and the U.N.’s Food and Agricultural Organization. “We haven't seen any true indication that ...
Source: Science of Aging Knowledge Environment - April 5, 2024 Category: Geriatrics Source Type: research
Viruses, Vol. 16, Pages 563: In Ovo Models to Predict Virulence of Highly Pathogenic Avian Influenza H5-Viruses for Chickens and Ducks
Nancy Beerens
Highly pathogenic avian influenza (HPAI) H5-viruses are circulating in wild birds and are repeatedly introduced to poultry causing outbreaks in the Netherlands since 2014. The largest epizootic ever recorded in Europe was caused by HPAI H5N1 clade 2.3.4.4b viruses in the period 2021–2022. The recent H5-clade 2.3.4.4 viruses were found to differ in their virulence for chickens and ducks. Viruses causing only mild disease may remain undetected, increasing the risk of virus spread to other farms, wild birds and mammals. We developed in ovo models to determine the virulence of HPAI viruses for ...
Source: Viruses - April 4, 2024 Category: Virology Authors: Luca Bordes Jos é L. Gonzales Sandra Vreman Sandra Venema Nadia Portier Evelien A. Germeraad Wim H. M. van der Poel Nancy Beerens Tags: Article Source Type: research
Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone
Eur J Med Chem. 2024 Mar 12;269:116305. doi: 10.1016/j.ejmech.2024.116305. Online ahead of print.ABSTRACTInspired by our earlier findings regarding neuraminidase (NA) inhibitors interacting with 150-cavity or 430-cavity of NA, sixteen novel polyheterocyclic NA inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone were designed and synthesized based on the lead compound ZINC13401480. Of the synthesized compounds, compound N5 targeting 150-cavity exerts the best inhibitory activity against the wild-type H5N1 NA, with IC50 value of 0.14 μM, which is superior to oseltamivir carboxylate (OSC) (IC50 = 0.31 μM). Comp...
Source: European Journal of Medicinal Chemistry - March 22, 2024 Category: Chemistry Authors: Lin Lin Shang Zhi Jian Zhong Li Ping Cheng Source Type: research
A computational approach to design a multiepitope vaccine against H5N1 virus
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the poultry business. The rapid rate of mutation of H5N1 viruses makes the who... (Source: Virology Journal)
Source: Virology Journal - March 20, 2024 Category: Virology Authors: Fatemeh Dashti, Arash Raisi, Ghazaleh Pourali, Zahra Sadat Razavi, Fatemeh Ravaei, Javid Sadri Nahand, Fatemeh Kourkinejad-Gharaei, Seyed Mohammad Ali Mirazimi, Javad Zamani, Hossein Tarrahimofrad, Seyed Mohammad Reza Hashemian and Hamed Mirzaei Tags: Research Source Type: research
Scientists in Antarctica track ‘baffling’ virus that could decimate penguins and other polar animals
A 23-meter-long sailboat set off last week from Argentina for Antarctica’s Weddell Sea with eight scientists, lots of cloacal swabs, and a genetic fingerprinting machine aboard. The
Australis
is headed for the southern continent’s teeming colonies of Adélie penguins, other seabirds, and marine mammals. The
goal
: to search for signs of a deadly virus that has nearly circled the world over the past 4 years, leaving behind a trail of devastated wildlife.
Last month, Spanish researchers
confirmed
that H5N1, the highly pathogenic form of avian influenza, had finally turned up—as long ...
Source: Science of Aging Knowledge Environment - March 18, 2024 Category: Geriatrics Source Type: research
Bycatch and pollution are the main threats for Burmeister's porpoises inhabiting a high-industrialized bay in the Humboldt current system
We report a dead Burmeister's porpoise positive for avian flu virus A (H5N1). Metals analyzed were found in muscle and skin tissues of stranded Burmeister's porpoises in the following order (Zn > Cu > Cr > As > Hg > Pb > Cd). Although we could not assess pollution as a cause of mortality, Cr, As and Pb concentrations exceeded the concentrations found in other porpoises species worldwide. We conclude that bycatch and pollution as the main threats for Burmeister's porpoise survival in northern Chile. Future studies should investigate the use of acoustic deterrent alarms to mitigate the bycatch in the bay an...
Source: Environmental Research - March 16, 2024 Category: Environmental Health Authors: Ana M Garc ía-Cegarra Anna Hall Emma Mart ínez-López Source Type: research
