The importance of rapid and robust availability of epidemiological data for real-time mapping of the risk of avian influenza a (H5N1) spread
Pathog Glob Health. 2023 Jun 20:1-4. doi: 10.1080/20477724.2023.2228055. Online ahead of print.NO ABSTRACTPMID:37340625 | DOI:10.1080/20477724.2023.2228055 (Source: Pathogens and Global Health)
Source: Pathogens and Global Health - June 21, 2023 Category: International Medicine & Public Health Authors: Francesco Branda Sandra Mazzoli Source Type: research
Viruses, Vol. 15, Pages 1403: Genetic Characterization and Pathogenesis of H5N1 High Pathogenicity Avian Influenza Virus Isolated in South Korea during 2021 & ndash;2022
In conclusion, consideration of both genetic and pathogenic traits of H5N1 HPAI viruses is required for effective viral control. (Source: Viruses)
Source: Viruses - June 20, 2023 Category: Virology Authors: Ra Mi Cha Yu-Na Lee Min-Ji Park Yoon-Gi Baek Jae-in Shin Chang Hwa Jung Mingeun Sagong Gyeong-Beom Heo Yong-Myung Kang Kwang-Nyeong Lee Youn-Jeong Lee Eun-Kyoung Lee Tags: Communication Source Type: research
Viruses, Vol. 15, Pages 1387: The Evolution of Highly Pathogenic Avian Influenza A (H5) in Poultry in Nigeria, 2021 & ndash;2022
In this study, we characterized the genomes of 97 influenza A viruses of the subtypes H5N1, H5N2, and H5N8, which were identified in different agro-ecological zones and farms during the 2021–2022 epidemic. The phylogenetic analysis of the HA genes showed a widespread distribution of the H5Nx clade 2.3.4.4b and similarity with the HPAI H5Nx viruses that have been detected in Europe since late 2020. The topology of the phylogenetic trees indicated the occurrence of several independent introductions of the virus into the country, followed by a regional evolution of the virus that was most probably linked to its ...
Source: Viruses - June 17, 2023 Category: Virology Authors: Clement Meseko Adelaide Milani Bitrus Inuwa Chinonyerem Chinyere Ismaila Shittu James Ahmed Edoardo Giussani Elisa Palumbo Bianca Zecchin Francesco Bonfante Silvia Maniero Ang élique Angot Mamadou Niang Alice Fusaro Federica Gobbo Calogero Terregino Taiw Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1383: The Molecular Epidemiology of Clade 2.3.4.4B H5N1 High Pathogenicity Avian Influenza in Southern Africa, 2021 & ndash;2022
In this study, the complete or partial genomes of 117 viruses from the SA outbreaks in 2021–2022 were analyzed to decipher the sub-regional spread of the disease. Our analysis showed that seven H5N1 sub-genotypes were associated with the initial outbreaks, but by late 2022 only two sub-genotypes still circulated. Furthermore, SA poultry was not the source of Lesotho’s outbreaks, and the latter was most likely an introduction from wild birds. Similarly, SA and Botswana’s outbreaks in 2021 were unrelated, but viruses of Botswana’s unique sub-genotype were introduced int...
Source: Viruses - June 16, 2023 Category: Virology Authors: Celia Abolnik Thandeka Phiri Belinda Peyrot Renee de Beer Albert Snyman David Roberts Katrin Ludynia Frances Jordaan Michele Maartens Zehaad Ismail Christine Strydom Gerbrand van der Zel Jade Anthony Nadine Daniell Liesl De Boni John Grewar Adriaan Olivie Tags: Article Source Type: research
Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b
A. Graaf et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 14, 2023 Category: Infectious Diseases Source Type: research
Viruses, Vol. 15, Pages 1344: Efficient and Informative Laboratory Testing for Rapid Confirmation of H5N1 (Clade 2.3.4.4) High-Pathogenicity Avian Influenza Outbreaks in the United Kingdom
Banyard
Ian H. Brown
During the early stages of the UK 2021-2022 H5N1 high-pathogenicity avian influenza virus (HPAIV) epizootic in commercial poultry, 12 infected premises (IPs) were confirmed by four real-time reverse-transcription–polymerase chain reaction (RRT)-PCRs, which identified the viral subtype and pathotype. An assessment was undertaken to evaluate whether a large sample throughput would challenge laboratory capacity during an exceptionally large epizootic; hence, assay performance across our test portfolio was investigated. Statistical analysis of RRT-PCR swab testing supported it to be fo...
Source: Viruses - June 9, 2023 Category: Virology Authors: Marek J. Slomka Scott M. Reid Alexander M. P. Byrne Vivien J. Coward James Seekings Jayne L. Cooper Jacob Peers-Dent Eric Agyeman-Dua Dilhani de Silva Rowena D. E. Hansen Ashley C. Banyard Ian H. Brown Tags: Article Source Type: research
Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021
J. Tian et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 8, 2023 Category: Infectious Diseases Source Type: research
IJERPH, Vol. 20, Pages 6030: Ecogeographic Drivers of the Spatial Spread of Highly Pathogenic Avian Influenza Outbreaks in Europe and the United States, 2016 & ndash;Early 2022
We examined the spatiotemporal extent of HPAI viruses across continents and characterized ecological and environmental predictors of virus spread between geographic regions by constructing a Bayesian phylodynamic generalized linear model (phylodynamic-GLM). The findings demonstrate localized epidemics of H5Nx throughout Europe in the first several years of the epizootic, followed by a singular branching point where H5N1 viruses were introduced to North America, likely via stopover locations throughout the North Atlantic. Once in the United States (US), H5Nx viruses spread at a greater rate between US-based regions as compa...
Source: International Journal of Environmental Research and Public Health - June 1, 2023 Category: Environmental Health Authors: Jonathon D. Gass Nichola J. Hill Lambodhar Damodaran Elena N. Naumova Felicia B. Nutter Jonathan A. Runstadler Tags: Article Source Type: research
US will vaccinate birds against avian flu for first time — what researchers think
Nature, Published online: 26 May 2023; doi:10.1038/d41586-023-01760-0The country plans to vaccinate endangered condors in an effort to curb unprecedented H5N1 outbreaks. (Source: Nature AOP)
Source: Nature AOP - May 26, 2023 Category: Research Authors: Max Kozlov Source Type: research
Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China
Emerg Infect Dis. 2023 Jun;29(6):1244-1249. doi: 10.3201/eid2906.221723.ABSTRACTTwo novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks to poultry and to public health.PMID:37209677 | DOI:10.3201/eid2906.221723 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 20, 2023 Category: Infectious Diseases Authors: Jing Yang Chunge Zhang Yue Yuan Ju Sun Lu Lu Honglei Sun Heting Sun Dong Chu Siyuan Qin Jianjun Chen Chengbo Zhang Xiyan Hao Weifeng Shi Wenjun Liu George F Gao Paul Digard Samantha Lycett Yuhai Bi Source Type: research
Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea
Emerg Infect Dis. 2023 May 19;29(7). doi: 10.3201/eid2907.221893. Online ahead of print.ABSTRACTWe isolated 5 highly pathogenic avian influenza A(H5N1) clade 2.3.4.4.b viruses from wild waterfowl feces in South Korea during November 2022. Whole-genome sequencing and phylogenetic analysis revealed novel genotypes produced by reassortment with Eurasian low pathogenicity avian influenza viruses. Enhanced surveillance will be required to improve prevention and control strategies.PMID:37204922 | DOI:10.3201/eid2907.221893 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 19, 2023 Category: Infectious Diseases Authors: Sun-Hak Lee Andrew Y Cho Tae-Hyeon Kim Seo-Jeong Ahn Ju Ho Song Heesu Lee Yun-Jeong Choi Nyamsuren Otgontogtokh Jung-Hoon Kwon Chang-Seon Song Dong-Hun Lee Source Type: research
Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea
Emerg Infect Dis. 2023 May 19;29(7). doi: 10.3201/eid2907.221893. Online ahead of print.ABSTRACTWe isolated 5 highly pathogenic avian influenza A(H5N1) clade 2.3.4.4.b viruses from wild waterfowl feces in South Korea during November 2022. Whole-genome sequencing and phylogenetic analysis revealed novel genotypes produced by reassortment with Eurasian low pathogenicity avian influenza viruses. Enhanced surveillance will be required to improve prevention and control strategies.PMID:37204922 | DOI:10.3201/eid2907.221893 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 19, 2023 Category: Infectious Diseases Authors: Sun-Hak Lee Andrew Y Cho Tae-Hyeon Kim Seo-Jeong Ahn Ju Ho Song Heesu Lee Yun-Jeong Choi Nyamsuren Otgontogtokh Jung-Hoon Kwon Chang-Seon Song Dong-Hun Lee Source Type: research
Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea
S. Lee et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - May 19, 2023 Category: Infectious Diseases Source Type: research
Long noncoding RNA #61 exerts a broad anti-influenza a virus effect by its long arm rings
Antiviral Res. 2023 May 15:105637. doi: 10.1016/j.antiviral.2023.105637. Online ahead of print.ABSTRACTEmerging evidence has demonstrated the critical role of long noncoding RNAs (lncRNAs) in regulating gene expression. However, the functional significance and mechanisms underlying influenza A virus (IAV)-host lncRNA interactions are still elusive. Here, we identified a functional lncRNA, LncRNA#61, as a broad anti-IAV factor. LncRNA#61 is highly upregulated by different subtypes of IAV, including human H1N1 virus and avian H5N1 and H7N9 viruses. Furthermore, nuclear-enriched LncRNA#61 can translocate from the nucleus to t...
Source: Antiviral Research - May 17, 2023 Category: Virology Authors: Jiao Hu Lei Zhang Xinxin Zheng Guoqing Wang Xia Chen Zenglei Hu Yu Chen Xiaoquan Wang Min Gu Shunlin Hu Xiaowen Liu Xinan Jiao Daxin Peng Xiufan Liu Source Type: research
