H5N1 highly pathogenic avian influenza clade 2.3.4.4b in wild and domestic birds: Introductions into the United States and reassortments, December 2021-April 2022
Virology. 2023 Aug 2;587:109860. doi: 10.1016/j.virol.2023.109860. Online ahead of print.ABSTRACTHighly pathogenic avian influenza viruses (HPAIVs) of the A/goose/Guangdong/1/1996 lineage H5 clade 2.3.4.4b continue to have a devastating effect on domestic and wild birds. Full genome sequence analyses using 1369 H5N1 HPAIVs detected in the United States (U.S.) in wild birds, commercial poultry, and backyard flocks from December 2021 to April 2022, showed three phylogenetically distinct H5N1 virus introductions in the U.S. by wild birds. Unreassorted Eurasian genotypes A1 and A2 entered the Northeast Atlantic states, whereas...
Source: Virology - August 12, 2023 Category: Virology Authors: Sungsu Youk Mia Kim Torchetti Kristina Lantz Julianna B Lenoch Mary Lea Killian Christina Leyson Sarah N Bevins Krista Dilione Hon S Ip David E Stallknecht Rebecca L Poulson David L Suarez David E Swayne Mary J Pantin-Jackwood Source Type: research
An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection
This study tested the ability of adjuvants based on delta inulin (Advax™) alone or combined with a TLR9 agonist (Advax-CpG™) to enhance the immunogenicity of recombinant H5 hemagglutinin antigen expressed in insect cells (rH5HA) to protect mice against lethal influenza infection. The Advax-adjuvanted rH5HA induced high serum hemagglutination inhibition activity, as well as Th1 and Th2 cytokine secreting CD4 and CD8 T cells. Immunization protected mice against a lethal heterosubtypic H5N1 virus challenge. Mice immunized with an Advax-adjuvanted rHA2 stem antigen prepared by enzymatic cleavage of rH5HA produced serum ant...
Source: Vaccine - August 11, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza a and B viruses
Antiviral Res. 2023 Aug 9:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A (H1N1)pdm09, A (H3N2), A (H5N1), and A (H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection
This study tested the ability of adjuvants based on delta inulin (Advax™) alone or combined with a TLR9 agonist (Advax-CpG™) to enhance the immunogenicity of recombinant H5 hemagglutinin antigen expressed in insect cells (rH5HA) to protect mice against lethal influenza infection. The Advax-adjuvanted rH5HA induced high serum hemagglutination inhibition activity, as well as Th1 and Th2 cytokine secreting CD4 and CD8 T cells. Immunization protected mice against a lethal heterosubtypic H5N1 virus challenge. Mice immunized with an Advax-adjuvanted rHA2 stem antigen prepared by enzymatic cleavage of rH5HA produced serum ant...
Source: Vaccine - August 11, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses
Antiviral Res. 2023 Aug 9;217:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A(H1N1)pdm09, A(H3N2), A(H5N1), and A(H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa K Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses
Antiviral Res. 2023 Aug 9;217:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A(H1N1)pdm09, A(H3N2), A(H5N1), and A(H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa K Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses
Antiviral Res. 2023 Aug 9;217:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A(H1N1)pdm09, A(H3N2), A(H5N1), and A(H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa K Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses
Antiviral Res. 2023 Aug 9;217:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A(H1N1)pdm09, A(H3N2), A(H5N1), and A(H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa K Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses
Antiviral Res. 2023 Aug 9;217:105701. doi: 10.1016/j.antiviral.2023.105701. Online ahead of print.ABSTRACTNeuraminidase inhibitors (NAIs) are recommended for influenza treatment and prevention worldwide. The most widely prescribed NAI is oral oseltamivir, while inhaled zanamivir is less commonly used. Using phenotypic neuraminidase (NA) enzymatic assays and molecular modeling approaches, we examined the ability of the investigational orally-dosed NAI AV5080 to inhibit viruses of the influenza A(H1N1)pdm09, A(H3N2), A(H5N1), and A(H7N9) subtypes and the influenza B/Victoria- and B/Yamagata-lineages containing NA substitutio...
Source: Antiviral Research - August 11, 2023 Category: Virology Authors: Andrei A Ivashchenko Jeremy C Jones Dmitry O Shkil Yan A Ivanenkov Philippe Noriel Q Pascua Melissa K Penaflor Ruben N Karapetian Elena A Govorkova Alexandre V Ivachtchenko Source Type: research
Emergence and potential transmission route of avian influenza A (H5N1) virus in domestic cats in Poland, June 2023
Euro Surveill. 2023 Aug;28(31). doi: 10.2807/1560-7917.ES.2023.28.31.2300390.ABSTRACTIn June 2023, a fatal disease outbreak in cats occurred in Poland. Most cases tested in Poland (29 of 47) were positive for highly pathogenic avian influenza (HPAI) A (H5N1) virus. Genetic analyses revealed clade 2.3.4.4b with point mutations indicative of initial mammalian hosts adaptations. Cat viral sequences were highly similar (n = 21), suggesting a potential common infection source. To investigate possible infection routes, our group tested food samples from affected households. HPAI H5N1 virus was detected in one poultry meat sample...
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Lukasz Rabalski Aleksandra Milewska Anne Pohlmann Karolina Gackowska Tomasz Lepionka Klaudiusz Szczepaniak Agnieszka Swiatalska Izabela Sieminska Zbigniew Arent Martin Beer Marion Koopmans Maciej Grzybek Krzysztof Pyrc Source Type: research
Outbreak of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in cats, Poland, June to July 2023
ConclusionThe scale of HPAI H5N1 virus infection in cats in Poland is worrying. One of the possible sources seems to be poultry meat, but to date no such meat has been identified with certainty. Surveillance should be stepped up on poultry, but also on certain species of farmed mammals kept close to infected poultry farms.PMID:37535474 | DOI:10.2807/1560-7917.ES.2023.28.31.2300366 (Source: Euro Surveill)
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Katarzyna Doma ńska-Blicharz Edyta Świętoń Agnieszka Świątalska Isabella Monne Alice Fusaro Karolina Tarasiuk Krzysztof Wyrostek Natalia Sty ś-Fijoł Aleksandra Giza Marta Pietruk Bianca Zechchin Ambra Pastori Łukasz Adaszek Ma łgorzata Pomorska- Source Type: research
Highly pathogenic avian influenza A(H5N1) virus infection on multiple fur farms in the South and Central Ostrobothnia regions of Finland, July 2023
Euro Surveill. 2023 Aug;28(31). doi: 10.2807/1560-7917.ES.2023.28.31.2300400.ABSTRACTSince mid-July 2023, an outbreak caused by highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b genotype BB is ongoing among farmed animals in South and Central Ostrobothnia, Finland. Infections in foxes, American minks and raccoon dogs have been confirmed on 20 farms. Genetic analysis suggests introductions from wild birds scavenging for food in farm areas. Investigations point to direct transmission between animals. While no human infections have been detected, control measures are being implemented to limit spread and human ex...
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Erika Lindh Hanna Lounela Niina Ikonen Tuija Kantala Carita Savolainen-Kopra Ari Kauppinen Pamela Österlund Lauri Kareinen Anna Katz Tiina Nokireki Jari Jalava Laura London Marjaana Pitk äpaasi Jaana Vuolle Anna-Liisa Punto-Luoma Riikka Kaarto Liina Vou Source Type: research
Highly pathogenic avian influenza A(H5N1) virus infection on multiple fur farms in the South and Central Ostrobothnia regions of Finland, July 2023
Euro Surveill. 2023 Aug;28(31):2300400. doi: 10.2807/1560-7917.ES.2023.28.31.2300400.ABSTRACTSince mid-July 2023, an outbreak caused by highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b genotype BB is ongoing among farmed animals in South and Central Ostrobothnia, Finland. Infections in foxes, American minks and raccoon dogs have been confirmed on 20 farms. Genetic analysis suggests introductions from wild birds scavenging for food in farm areas. Investigations point to direct transmission between animals. While no human infections have been detected, control measures are being implemented to limit spread and ...
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Erika Lindh Hanna Lounela Niina Ikonen Tuija Kantala Carita Savolainen-Kopra Ari Kauppinen Pamela Österlund Lauri Kareinen Anna Katz Tiina Nokireki Jari Jalava Laura London Marjaana Pitk äpaasi Jaana Vuolle Anna-Liisa Punto-Luoma Riikka Kaarto Liina Vou Source Type: research
Outbreak of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in cats, Poland, June to July 2023
ConclusionThe scale of HPAI H5N1 virus infection in cats in Poland is worrying. One of the possible sources seems to be poultry meat, but to date no such meat has been identified with certainty. Surveillance should be stepped up on poultry, but also on certain species of farmed mammals kept close to infected poultry farms.PMID:37535474 | PMC:PMC10401911 | DOI:10.2807/1560-7917.ES.2023.28.31.2300366 (Source: Euro Surveill)
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Katarzyna Doma ńska-Blicharz Edyta Świętoń Agnieszka Świątalska Isabella Monne Alice Fusaro Karolina Tarasiuk Krzysztof Wyrostek Natalia Sty ś-Fijoł Aleksandra Giza Marta Pietruk Bianca Zechchin Ambra Pastori Łukasz Adaszek Ma łgorzata Pomorska- Source Type: research
Emergence and potential transmission route of avian influenza A (H5N1) virus in domestic cats in Poland, June 2023
Euro Surveill. 2023 Aug;28(31):2300390. doi: 10.2807/1560-7917.ES.2023.28.31.2300390.ABSTRACTIn June 2023, a fatal disease outbreak in cats occurred in Poland. Most cases tested in Poland (29 of 47) were positive for highly pathogenic avian influenza (HPAI) A (H5N1) virus. Genetic analyses revealed clade 2.3.4.4b with point mutations indicative of initial mammalian hosts adaptations. Cat viral sequences were highly similar (n = 21), suggesting a potential common infection source. To investigate possible infection routes, our group tested food samples from affected households. HPAI H5N1 virus was detected in one poultry mea...
Source: Euro Surveill - August 3, 2023 Category: Infectious Diseases Authors: Lukasz Rabalski Aleksandra Milewska Anne Pohlmann Karolina Gackowska Tomasz Lepionka Klaudiusz Szczepaniak Agnieszka Swiatalska Izabela Sieminska Zbigniew Arent Martin Beer Marion Koopmans Maciej Grzybek Krzysztof Pyrc Source Type: research
