The associations between invasive group A streptococcal disease and infection with influenza, varicella or hepatitis C viruses: A data linkage study, Victoria, Australia
Invasive group A streptococcal disease (iGAS) is a rare and life-threatening infection. It occurs when group A Streptococcus bacteria (GAS, Streptococcus pyogenes) invade otherwise sterile sites of the body, such as the blood and cerebrospinal fluid.[1] Globally, it is estimated that 15 –25% of iGAS cases are fatal.[1] Severe manifestations such as sepsis, streptococcal toxic shock syndrome (STSS) and necrotising fasciitis have higher case fatality rates, even in well-resourced settings.[1, 2] iGAS is managed with antibiotics, and often requires surgery and supportive care for or gan dysfunction.[2] However, patients fre...
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Jessie J. Goldsmith, Christy Vu, Ziheng Zhu, Jennifer MacLachlan, Tilda N. Thomson, Patricia Therese Campbell, Katherine B. Gibney Source Type: research
Epidemiological shifts in and impact of COVID-19 on streptococcal toxic shock syndrome in Japan: A genotypic analysis of Group A Streptococcus isolates
Group A Streptococcus (GAS, Streptococcus pyogenes) strains cause pharyngitis, tonsillitis, skin and soft tissue infections, bacteremia, and scarlet fever. Since the late 1980s, streptococcal toxic shock syndrome (STSS) caused by GAS infection has been a major health problem in several countries [1 –5]. The characteristic symptoms progress rapidly and are fulminant from disease onset. Patients can develop necrotizing fasciitis, acute kidney failure, acute respiratory distress syndrome, disseminated intravascular coagulopathy, and multi-organ failure within a few hours of disease onset, leadi ng to shock and even death. (...
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Takahiro Yamaguchi, Junko Isobe, Emi Maenishi, Yoshimi Date, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Mami Takano, Shinya Tsukamoto, Yoshiko Kanda, Makoto Ohnishi, Yukihiro Akeda, The Working G Source Type: research
A foodborne outbreak of Group A streptococcus: an under-recognised method of spread
This report details a GAS outbreak in New Zealand that was associated with a foodborne route of transmission. This outbreak was relevant in the New Zealand context given the high incidence of rheumatic fever (RF).PMID:38301203 | DOI:10.26635/6965.6313 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - February 1, 2024 Category: General Medicine Authors: Kate Gatman Bryn Thompson Jay Harrower Subha Rajanaidu Source Type: research
Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series
Recent alerts have highlighted an increase in group A streptococcal (GAS) infections since 2022 in Europe and the United States. Streptococcus pyogenes can cause limited skin or mucosal disease, but can also pres... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - January 29, 2024 Category: Intensive Care Authors: Marijke Peetermans, Veerle Matheeussen, Cedric Moerman, Fr éderic De Rydt, Sabine Thieren, Emily Pollet, Michael Casaer, Benjamin De Backer, Rudi De Paep, Yves Debaveye, Lars Desmet, Stefanie Desmet, Els I. M. Duval, Vincent Fraipont, Dieter Geysels, Gre Tags: Research Source Type: research
Detection of toxigenic M1 < sub > UK < /sub > lineage group A Streptococcus clones in Taiwan
CONCLUSIONS: Our results suggested that the M1UK lineage clone has introduced in Taiwan. In Taiwan, the COVID-19 restrictions were officially released in March 2023; therefore, it would be crucial to continuously monitor the M1UK expansion and its related diseases in the post COVID-19 era.PMID:38278671 | DOI:10.1016/j.jmii.2024.01.004 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - January 26, 2024 Category: Microbiology Authors: Chuan Chiang-Ni Chih-Yun Hsu Yu-Hsuan Yeh Chia-Yu Chi Shuying Wang Pei-Jane Tsai Cheng-Hsun Chiu Source Type: research
Dynamics of the Oral Microbiome During Initial Military Training at Fort Benning, Georgia
CONCLUSIONS: The temporary convergence of microbiomes is coincident with a rise in communicable infections in this population. The dynamic response of microbiomes during initial military training supports similar observations in the literature of transient convergence of the human microbiome under cohabitation in the time frame including in this experiment. This population and the associated longitudinal studies allow for controlled studies of human microbiome under diverse conditions.PMID:38243767 | DOI:10.1093/milmed/usad488 (Source: Military Medicine)
Source: Military Medicine - January 20, 2024 Category: International Medicine & Public Health Authors: Kristina K Zudock Robert Player Amanda Ernlund Collin M Timm Caroline E English Michael W Ellis David R Tribble D Scott Merrell Jason W Bennett Eugene V Millar Source Type: research
Group A Streptococcus interactions with the host across time and space
Curr Opin Microbiol. 2024 Feb;77:102420. doi: 10.1016/j.mib.2023.102420. Epub 2024 Jan 14.ABSTRACTGroup A Streptococcus (GAS) has a fantastically wide tissue tropism in humans, manifesting as different diseases depending on the strain's virulence factor repertoire and the tissue involved. Activation of immune cells and pro-inflammatory signaling has historically been considered an exclusively host-protective response that a pathogen would seek to avoid. However, recent advances in human and animal models suggest that in some tissues, GAS will activate and manipulate specific pro-inflammatory pathways to promote growth, nut...
Source: Current Opinion in Microbiology - January 14, 2024 Category: Microbiology Authors: Stephanie Guerra Christopher LaRock Source Type: research
Eliminating the invading extracellular and intracellular FnBp+ bacteria from respiratory epithelial cells by autophagy mediated through FnBp-Fn-Integrin α5β1 axis
ConclusionsVarious FnBp from FnBp+ bacteria have the ability to initiate autophagy via FnBp-Fn-Integrin α5β1 axis to promote the removal of invading bacteria from epithelial cells in the presence of fewer invaders. S100A8 is a key molecule downstream of Integrin α5β1 in this autophagy pathway. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 9, 2024 Category: Microbiology Source Type: research
Group A Streptococcus strains causing meningitis without distinct invasive phenotype
Group A streptococcal (GAS) meningitis causes high morbidity and mortality. To elucidate the invasiveness of GAS in meningitis, we compared five GAS meningitis isolates to otitis and colonizing isolates. Genetic and virulence traits were comparable for all strains suggesting that meningitis likely resulted from a continuous spread of the infection. AbstractGroup A streptococcal (GAS; akaStreptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from five cases of mening...
Source: MicrobiologyOpen - January 5, 2024 Category: Microbiology Authors: Laura Marquardt,
Federica Andreoni,
Mathilde Boumasmoud,
Tiziano A. Schweizer,
Dorothea M. Heuberger,
Elena Parietti,
Sanne Hertegonne,
Jana Epprecht,
Dario Mattle,
Anna K. Raez,
Ewerton Marques ‐Maggio,
Reto A. Schuepbach,
Barbara Hasse,
S Tags: COMMENTARY Source Type: research
Concurrent Familial Cluster of Acute Post-Streptococcal Glomerulonephritis Due to Group A Streptococcus emm2 Type During the Ongoing European Outbreak (2022-23)
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - January 1, 2024 Category: Pediatrics Source Type: research
