GSE249596 PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response
Contributors : Monireh Asoudeh ; Nicole Nguyen ; Mitch Raith ; Desiree S Denman ; Uche C Anozie ; Mahshid Mokhtarnejad ; Bamin Khomami ; Kaitlyn M Skotty ; Sami Isaac ; Taylor Gebhart ; Lauren Vaigneur ; Aga Gelgie ; Oudessa Kerro Dego ; Trevor Freeman ; Jon Beever ; Paul DalhaimerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPoly-ethylene-glycol (PEG)-based nanoparticles (NPs) - including cylindrical micelles (CNPs), spherical micelles (SNPs), and PEGylated liposomes (PLs) - are hypothesized to be cleared in vivo by opsonization followed by liver macrophage phagocytosi...
Source: GEO: Gene Expression Omnibus - December 27, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies
Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, amo...
Source: Critical Reviews in Microbiology - December 23, 2023 Category: Microbiology Authors: Lionel Schiavolin Geoffrey Deneubourg Jenny Steinmetz Pierre R Smeesters Anne Botteaux Source Type: research
Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies
Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, amo...
Source: Critical Reviews in Microbiology - December 23, 2023 Category: Microbiology Authors: Lionel Schiavolin Geoffrey Deneubourg Jenny Steinmetz Pierre R Smeesters Anne Botteaux Source Type: research
Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies
Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, amo...
Source: Critical Reviews in Microbiology - December 23, 2023 Category: Microbiology Authors: Lionel Schiavolin Geoffrey Deneubourg Jenny Steinmetz Pierre R Smeesters Anne Botteaux Source Type: research
Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies
Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, amo...
Source: Critical Reviews in Microbiology - December 23, 2023 Category: Microbiology Authors: Lionel Schiavolin Geoffrey Deneubourg Jenny Steinmetz Pierre R Smeesters Anne Botteaux Source Type: research
Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies
Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, amo...
Source: Critical Reviews in Microbiology - December 23, 2023 Category: Microbiology Authors: Lionel Schiavolin Geoffrey Deneubourg Jenny Steinmetz Pierre R Smeesters Anne Botteaux Source Type: research
A pharmacy-led sore throat test and treat (STTT) service: antigen testing and antibiotic supply rates during the period of heightened public awareness of Group A Streptococcus infections
ConclusionsOur findings suggest that, despite a dramatic increase in sore throat consultation rates in response to media reports, the pre-specified pathway followed by pharmacists ensured appropriate use of antibiotics, and absorbed a substantial workload that would otherwise end up in other healthcare settings. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 22, 2023 Category: Microbiology Source Type: research
Systematic identification and repurposing of FDA-approved drugs as antibacterial agents against Streptococcus pyogenes: In silico and in vitro studies
In this study, 1826 FDA approved drugs have been identified through high-throughput virtual screening. Free Energy Perturbation (FEP) based binding free energy calculations have been performed at the final step of the virtual screening funnel to ensure high accuracy in silico results. Three compounds identified have been tested for susceptibility of S. pyogenes MTCC 442 strain and two antibiotic-resistant clinical isolates of S. pyogenes using microdilution assay. Among the three, two drugs Amlodipine Besylate (Amd) and Ranitidine hydrochloride (Rnt) have shown inhibition against all the tested strains and its mechanism of...
Source: International Journal of Biological Macromolecules - December 15, 2023 Category: Biochemistry Authors: Judith Gracia Damodharan Perumal Prabu Dhandapani Preethi Ragunathan Source Type: research
Systematic identification and repurposing of FDA-approved drugs as antibacterial agents against Streptococcus pyogenes: In silico and in vitro studies
In this study, 1826 FDA approved drugs have been identified through high-throughput virtual screening. Free Energy Perturbation (FEP) based binding free energy calculations have been performed at the final step of the virtual screening funnel to ensure high accuracy in silico results. Three compounds identified have been tested for susceptibility of S. pyogenes MTCC 442 strain and two antibiotic-resistant clinical isolates of S. pyogenes using microdilution assay. Among the three, two drugs Amlodipine Besylate (Amd) and Ranitidine hydrochloride (Rnt) have shown inhibition against all the tested strains and its mechanism of...
Source: International Journal of Biological Macromolecules - December 15, 2023 Category: Biochemistry Authors: Judith Gracia Damodharan Perumal Prabu Dhandapani Preethi Ragunathan Source Type: research
Revising the value of Antistreptolysin O titre in childhood and its interpretation in the diagnostic approach of rheumatic diseases
Conclusion: Our study established a new ULN normal value of streptococcal serology in a childhood and adolescent population of Italy, suggesting the need to extend this revaluation to the critical areas, in order to avoid underestimating ARF diagnosis. The correct interpretation of ASO and anti-DNase B values in the context of rheumatic diseases has been discussed.What is Known:• The global burden of disease caused by group A streptococcus is not known and remains an important cause of morbidity and mortality. Acute rheumatic fever continues to be a serious worldwide public health problem and a recent recurrence of group...
Source: European Journal of Pediatrics - December 1, 2023 Category: Pediatrics Source Type: research
2135 Cooking on GAS: implementing guidelines for suspected Group A streptococcus in the emergency department at royal Aberdeen childrens hospital
Conclusion
21 BTS were sent in the 2 months pre-guideline (October – December 2022), and 137 BTS were sent in the 6 months post-guideline (December 2022 – June 2023). GAS positivity was 38.1% versus 33.6% respectively. Rates of GAS-positive patients receiving antibiotics on discharge decreased from 100.0% to 69.6% (p=0.077); all GAS-positive patients not given antibiotics on discharge were prescribed antibiotics after swab result. GAS-negative patients receiving antibiotics fell from 69.2% to 57.1% (p=0.543). FeverPAIN ≥4 had a PPV of 50% pre-guideline, whilst the post-guideline revised treatment threshold F...
Source: Emergency Medicine Journal - November 28, 2023 Category: Emergency Medicine Authors: Addinall, A., Bowbeer, C., Stephen, F. Tags: APEM Elizabeth Molyneux Prize Papers Source Type: research
Epidemiology and emm types among group A streptococcal pharyngitis in Finland: a prospective laboratory-based study
ConclusionAge distribution among GAS pharyngitis cases was significantly different between genders (p< 0.0001). In addition, age group specific and seasonal variations inemm GAS types causing the disease were observed. These findings warrant further investigation, especially for understanding population-based spread of GAS even in more detail. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 27, 2023 Category: Microbiology Source Type: research
Group A Streptococcus invasive infection in children: Epidemiologic changes and implications
Rev Esp Quimioter. 2023 Nov;36 Suppl 1:33-36. doi: 10.37201/req/s01.09.2023. Epub 2023 Nov 24.ABSTRACTGroup A Streptococcus (GAS) can cause a broad array of clinical manifestations and complications. Recently, in post COVID-19 postpandemic months, there has been an increased incidence and severity of invasive infections in the pediatric age group in Spain and other European countries with high morbidity, affecting mostly to young children, associated with seasonal peaks in incidence of viral respiratory pathogens. The increased in incidence and severity has not been associated with predominant GAS strains, but rather to th...
Source: Revista Espanola de Quimioterapia - November 24, 2023 Category: Drugs & Pharmacology Authors: J T Ramos Amador A Berzosa S ánchez M Ill án Ramos Source Type: research
Group A Streptococcus invasive infection in children: Epidemiologic changes and implications
Rev Esp Quimioter. 2023 Nov;36 Suppl 1:33-36. doi: 10.37201/req/s01.09.2023. Epub 2023 Nov 24.ABSTRACTGroup A Streptococcus (GAS) can cause a broad array of clinical manifestations and complications. Recently, in post COVID-19 postpandemic months, there has been an increased incidence and severity of invasive infections in the pediatric age group in Spain and other European countries with high morbidity, affecting mostly to young children, associated with seasonal peaks in incidence of viral respiratory pathogens. The increased in incidence and severity has not been associated with predominant GAS strains, but rather to th...
Source: Revista Espanola de Quimioterapia - November 24, 2023 Category: Drugs & Pharmacology Authors: J T Ramos Amador A Berzosa S ánchez M Ill án Ramos Source Type: research
Group A Streptococcus invasive infection in children: Epidemiologic changes and implications
Rev Esp Quimioter. 2023 Nov;36 Suppl 1:33-36. doi: 10.37201/req/s01.09.2023. Epub 2023 Nov 24.ABSTRACTGroup A Streptococcus (GAS) can cause a broad array of clinical manifestations and complications. Recently, in post COVID-19 postpandemic months, there has been an increased incidence and severity of invasive infections in the pediatric age group in Spain and other European countries with high morbidity, affecting mostly to young children, associated with seasonal peaks in incidence of viral respiratory pathogens. The increased in incidence and severity has not been associated with predominant GAS strains, but rather to th...
Source: Revista Espanola de Quimioterapia - November 24, 2023 Category: Drugs & Pharmacology Authors: J T Ramos Amador A Berzosa S ánchez M Ill án Ramos Source Type: research
