Group A < em > Streptococcus < /em > adaptation to diverse niches: lessons from transcriptomic studies

Crit Rev Microbiol. 2023 Dec 23:1-25. doi: 10.1080/1040841X.2023.2294905. Online ahead of print.ABSTRACTGroup A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. Moreover, post infection auto-immune sequelae arise by a yet not fully understood mechanism. The ability of GAS to cause a wide variety of infections is linked to the expression of a large set of virulence factors and their transcriptional regulation in response to various physiological environments. The use of transcriptomics, among others -omics technologies, in addition to traditional molecular methods, has led to a better understanding of GAS pathogenesis and host adaptation mechanisms. This review focusing on bacterial transcriptomic provides new insight into gene-expression patterns in vitro, ex vivo and in vivo with an emphasis on metabolic shifts, virulence genes expression and transcriptional regulators role.PMID:38140809 | DOI:10.1080/1040841X.2023.2294905
Source: Critical Reviews in Microbiology - Category: Microbiology Authors: Source Type: research