To ASLO or Not to ASLO: Utility of the ASLO Test in Dermatology
CONCLUSIONS: Although the applicability of ASLO for the spectrum of dermatological diseases remains unclear, our results enhance the practical relevance of the test. We showed a higher prevalence of positive ASLO tests in psoriasis and erythema nodosum cases and a lower prevalence in vasculitis. Notably, ASLO was positive in all psoriasis subtypes, suggesting high utility of the test for psoriasis.PMID:38616666 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Afik Tibi Ziyad Khamaysi Emily Avitan-Hersh Source Type: research
A flow cytometry-based assay to determine the ability of anti-Streptococcus pyogenes antibodies to mediate monocytic phagocytosis in human sera
J Immunol Methods. 2024 Mar 6:113652. doi: 10.1016/j.jim.2024.113652. Online ahead of print.ABSTRACTStreptococcus pyogenes, commonly referred to as Group A Streptococcus (Strep A), causes a spectrum of diseases, with the potential to progress into life-threatening illnesses and autoimmune complications. The escalating threat of antimicrobial resistance, stemming from the prevalent reliance on antibiotic therapies to manage Strep A infections, underscores the critical need for the development of disease control strategies centred around vaccination. Phagocytes play a critical role in controlling Strep A infections, and phag...
Source: Journal of Immunological Methods - March 8, 2024 Category: Allergy & Immunology Authors: Elena Boero Martina Carducci Alexander J Keeley Francesco Berlanda Scorza Miren Iturriza Danilo Gomes Moriel Omar Rossi Source Type: research
A flow cytometry-based assay to determine the ability of anti-Streptococcus pyogenes antibodies to mediate monocytic phagocytosis in human sera
J Immunol Methods. 2024 Mar 6:113652. doi: 10.1016/j.jim.2024.113652. Online ahead of print.ABSTRACTStreptococcus pyogenes, commonly referred to as Group A Streptococcus (Strep A), causes a spectrum of diseases, with the potential to progress into life-threatening illnesses and autoimmune complications. The escalating threat of antimicrobial resistance, stemming from the prevalent reliance on antibiotic therapies to manage Strep A infections, underscores the critical need for the development of disease control strategies centred around vaccination. Phagocytes play a critical role in controlling Strep A infections, and phag...
Source: Journal of Immunological Methods - March 8, 2024 Category: Allergy & Immunology Authors: Elena Boero Martina Carducci Alexander J Keeley Francesco Berlanda Scorza Miren Iturriza Danilo Gomes Moriel Omar Rossi Source Type: research
A flow cytometry-based assay to determine the ability of anti-Streptococcus pyogenes antibodies to mediate monocytic phagocytosis in human sera
J Immunol Methods. 2024 Mar 6:113652. doi: 10.1016/j.jim.2024.113652. Online ahead of print.ABSTRACTStreptococcus pyogenes, commonly referred to as Group A Streptococcus (Strep A), causes a spectrum of diseases, with the potential to progress into life-threatening illnesses and autoimmune complications. The escalating threat of antimicrobial resistance, stemming from the prevalent reliance on antibiotic therapies to manage Strep A infections, underscores the critical need for the development of disease control strategies centred around vaccination. Phagocytes play a critical role in controlling Strep A infections, and phag...
Source: Journal of Immunological Methods - March 8, 2024 Category: Allergy & Immunology Authors: Elena Boero Martina Carducci Alexander J Keeley Francesco Berlanda Scorza Miren Iturriza Danilo Gomes Moriel Omar Rossi Source Type: research
A flow cytometry-based assay to determine the ability of anti-Streptococcus pyogenes antibodies to mediate monocytic phagocytosis in human sera
J Immunol Methods. 2024 Mar 6:113652. doi: 10.1016/j.jim.2024.113652. Online ahead of print.ABSTRACTStreptococcus pyogenes, commonly referred to as Group A Streptococcus (Strep A), causes a spectrum of diseases, with the potential to progress into life-threatening illnesses and autoimmune complications. The escalating threat of antimicrobial resistance, stemming from the prevalent reliance on antibiotic therapies to manage Strep A infections, underscores the critical need for the development of disease control strategies centred around vaccination. Phagocytes play a critical role in controlling Strep A infections, and phag...
Source: Journal of Immunological Methods - March 8, 2024 Category: Allergy & Immunology Authors: Elena Boero Martina Carducci Alexander J Keeley Francesco Berlanda Scorza Miren Iturriza Danilo Gomes Moriel Omar Rossi Source Type: research
Group A streptococcal collagen-like protein 1 restricts tumor growth in murine pancreatic adenocarcinoma and inhibits cancer-promoting neutrophil extracellular traps
DiscussionAltogether, we demonstrate that intra-tumoral GAS injections reduce PDAC growth, which is facilitated by Scl1, in part through inhibition of cancer promoting NETs. This work offers a novel strategy by which NETs can be targeted through Scl1 protein and potentiates its use as a cancer therapeutic. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 7, 2024 Category: Allergy & Immunology Source Type: research
Preadmission course and management of severe pediatric group A streptococcal infections during the 2022 –2023 outbreak: a single-center experience
ConclusionWe found no evidence supporting the hypothesis that the 2022 –2023 GAS outbreak was associated with a change in preadmission management possibly induced by the new recommendation for GAS pharyngitis. However, clinical manifestations before admission and comparative examination of time-series strongly suggest that viral co-circulation played an important rol e in this outbreak. (Source: Infection)
Source: Infection - March 1, 2024 Category: Infectious Diseases Source Type: research
Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infe... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - February 27, 2024 Category: Biomedical Science Authors: Lea A. T ölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers and Nikolai Siemens Tags: Research Source Type: research
Streptococcal infection and autoimmune diseases
Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. Streptococcus species are gram-positive bacteria that colonize the nasopharynx, respiratory tract, gastrointestinal tract, genitourinary tract, and skin. Group A Streptococcus (GAS) species cause various symptoms, ranging from mild infections, such as tonsillitis and pharyngitis, to serious infections, such as necrotizing fasciitis and streptococcal toxic shock syndrome. The contribution of GAS infections to several autoimmune diseases, including acute rheumatic fever, vasculitis,...
Source: Frontiers in Immunology - February 23, 2024 Category: Allergy & Immunology Source Type: research
Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022
Public Health Rep. 2024 Feb 20:333549241228525. doi: 10.1177/00333549241228525. Online ahead of print.ABSTRACTHomelessness increases the risk of acquiring an infectious disease. We conducted a systematic review of the literature to identify quantitative data related to infectious diseases and homelessness. We searched Google Scholar, PubMed, and SCOPUS for quantitative literature published from January 2003 through December 2022 in English from the United States and Canada. We excluded literature on vaccine-preventable diseases and HIV because these diseases were recently reviewed. Of the 250 articles that met inclusion cr...
Source: Public Health Reports - February 21, 2024 Category: International Medicine & Public Health Authors: Caroline J Waddell Carlos S Saldana Megan M Schoonveld Ashley A Meehan Christina K Lin Jay C Butler Emily Mosites Source Type: research
