Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus
This study was aimed at elucidating the basis for the loss of M protein production. The majority of M protein-negative (M−) variants had one C deletion at a tract of 8 cytidines starting at base 1,571 of the M1 mga gene, which is designated as c.1571C[8]. The C deletion led to a c.1571C[7] mga variant that has an open reading frame shift and encodes a Mga-M protein fusion protein. Transformation with a plasmid containing wild-type mga restored the production of the M protein in the c.1571C[7] mga variant. Isolates producing M protein (M+) were recovered following growth of the c.1571C[7] M protein-negative variant subcut...
Source: Frontiers in Microbiology - June 26, 2023 Category: Microbiology Source Type: research
Pharyngeal Co-Infections with Monkeypox Virus and Group A Streptococcus, United States, 2022
R. M. Kaiser et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 14, 2023 Category: Infectious Diseases Source Type: research
Surveillance of non-invasive group A Streptococcus infections in French ambulatory pediatrics before and during the COVID-19 pandemic: a prospective multicenter study from 2018 to 2022
Group A Streptococcus (GAS) can cause a wider variety of diseases than any other bacterial species, ranging from mild throat and skin infections to uncommon but life-threatening invasive diseases such as streptococcal toxic shock syndrome, necrotizing fasciitis, or bacteremia [1, 11]. The most common GAS infection in ambulatory pediatrics is tonsillopharyngitis (i.e., “strep throat”) [11]. In many countries, the diagnosis of GAS tonsillopharyngitis has been facilitated with the use of rapid antigen detection tests (RADTs) [Suppl 1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 5, 2023 Category: Infectious Diseases Authors: Pr J érémie F. Cohen, Dr Alexis Rybak, Dr Andreas Werner, Dr Fabienne Kochert, Dr Fabienne Cahn-Sellem, Dr Nathalie Gelbert, Dr François Vié Le Sage, Dr Christophe Batard, Mr Stéphane Béchet, Dr Hippolyte Corbaux, Dr Bruno Frandji, Dr Corinne Levy, Source Type: research
Surveillance of noninvasive group A Streptococcus infections in French ambulatory pediatrics before and during the COVID-19 pandemic: a prospective multicenter study from 2018-2022
Group A Streptococcus (GAS) can cause a wider variety of diseases than any other bacterial species, ranging from mild throat and skin infections to uncommon but life-threatening invasive diseases such as streptococcal toxic shock syndrome, necrotizing fasciitis, or bacteremia [1,2]. The most common GAS infection in ambulatory pediatrics is tonsillopharyngitis (i.e., “strep throat”) [2]. In many countries, the diagnosis of GAS tonsillopharyngitis has been facilitated with the use of rapid antigen detection tests (RADTs) [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 5, 2023 Category: Infectious Diseases Authors: J érémie F. Cohen, Alexis Rybak, Andreas Werner, Fabienne Kochert, Fabienne Cahn-Sellem, Nathalie Gelbert, François Vié Le Sage, Christophe Batard, Stéphane Béchet, Hippolyte Corbaux, Bruno Frandji, Corinne Levy, Robert Cohen Source Type: research
Methods to Analyze the Contribution of Complement Evasion Factor (CEF) to Streptococcus pyogenes Virulence
Methods Mol Biol. 2023;2674:119-129. doi: 10.1007/978-1-0716-3243-7_8.ABSTRACTGroup A Streptococcus (GAS, Streptococcus pyogenes) is an exclusively human pathogen that causes a range of diseases, including pharyngitis, tonsillitis, impetigo, erysipelas, necrotizing fasciitis, and toxic shock syndrome. Post-streptococcal sequelae include acute rheumatic fever and rheumatic heart disease. The bacterium produces a large arsenal of virulence factors that contribute to host tissue adhesion/colonization, bacterial spread, and host immune evasion. Immune evasion factors include proteins that interfere with complement, a system of...
Source: Mol Biol Cell - May 31, 2023 Category: Molecular Biology Authors: Haniyeh Aghababa Jacelyn M S Loh Thomas Proft Source Type: research
Detection of Inflammasome Activation in Murine Bone Marrow-Derived Macrophages Infected with Group A Streptococcus
Methods Mol Biol. 2023;2674:261-282. doi: 10.1007/978-1-0716-3243-7_18.ABSTRACTInflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which causes a wide range of diseases of varying severity. GAS secretes a multitude of virulence factors whereof the pore-forming protein streptolysin O (SLO)...
Source: Molecular Medicine - May 31, 2023 Category: Molecular Biology Authors: Christine Valfridsson Elsa Westerlund D óra Hancz Jenny J Persson Source Type: research
Surrogacy in Antimicrobial Susceptibility Testing of Group A Streptococcus [Letter]
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - May 24, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan
J Microbiol Immunol Infect. 2023 May 6:S1684-1182(23)00088-9. doi: 10.1016/j.jmii.2023.04.010. Online ahead of print.ABSTRACTHigh-level levofloxacin-resistant group A Streptococcus emerged in Taiwan in 2012. Among the 24 isolates identified, 23 belonged to emm12/ST36, most harbored the same GyrA and ParC mutations and were highly clonal. wgMLST showed them to be closely related to the Hong Kong scarlet fever outbreak strains. Continuous surveillance is warranted.PMID:37188572 | DOI:10.1016/j.jmii.2023.04.010 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 15, 2023 Category: Microbiology Authors: Ying-Chi Huang Jui-Fen Lai Chi-Jung Wu I-Wen Huang Shu-Chen Kuo Ching-Len Liao Tzu-Wen Huang Tsai-Ling Lauderdale Source Type: research
High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan
J Microbiol Immunol Infect. 2023 May 6:S1684-1182(23)00088-9. doi: 10.1016/j.jmii.2023.04.010. Online ahead of print.ABSTRACTHigh-level levofloxacin-resistant group A Streptococcus emerged in Taiwan in 2012. Among the 24 isolates identified, 23 belonged to emm12/ST36, most harbored the same GyrA and ParC mutations and were highly clonal. wgMLST showed them to be closely related to the Hong Kong scarlet fever outbreak strains. Continuous surveillance is warranted.PMID:37188572 | DOI:10.1016/j.jmii.2023.04.010 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 15, 2023 Category: Microbiology Authors: Ying-Chi Huang Jui-Fen Lai Chi-Jung Wu I-Wen Huang Shu-Chen Kuo Ching-Len Liao Tzu-Wen Huang Tsai-Ling Lauderdale Source Type: research
High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan
J Microbiol Immunol Infect. 2023 May 6:S1684-1182(23)00088-9. doi: 10.1016/j.jmii.2023.04.010. Online ahead of print.ABSTRACTHigh-level levofloxacin-resistant group A Streptococcus emerged in Taiwan in 2012. Among the 24 isolates identified, 23 belonged to emm12/ST36, most harbored the same GyrA and ParC mutations and were highly clonal. wgMLST showed them to be closely related to the Hong Kong scarlet fever outbreak strains. Continuous surveillance is warranted.PMID:37188572 | DOI:10.1016/j.jmii.2023.04.010 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 15, 2023 Category: Microbiology Authors: Ying-Chi Huang Jui-Fen Lai Chi-Jung Wu I-Wen Huang Shu-Chen Kuo Ching-Len Liao Tzu-Wen Huang Tsai-Ling Lauderdale Source Type: research
Viruses, Vol. 15, Pages 1160: Epidemiology of Respiratory Infections during the COVID-19 Pandemic
sposito
To face the COVID-19 outbreak, a wide range of non-pharmaceutical interventions (NPIs) aimed at limiting the spread of the virus in communities, such as mask-wearing, hand hygiene, social distancing, travel restrictions, and school closures, were introduced in most countries. Thereafter, a significant reduction of new asymptomatic and symptomatic COVID-19 cases occurred, although there were differences between countries according to the type and duration of the NPIs. In addition, the COVID-19 pandemic has been accompanied by significant variations in the global incidence of diseases due to the most common non-S...
Source: Viruses - May 13, 2023 Category: Virology Authors: Nicola Principi Giovanni Autore Greta Ramundo Susanna Esposito Tags: Review Source Type: research
The microbiome and rheumatic heart disease: current knowledge and future perspectives
Acta Cardiol. 2023 May 12:1-9. doi: 10.1080/00015385.2023.2207933. Online ahead of print.ABSTRACTRheumatic heart disease (RHD) is a cardiovascular disease caused by an autoimmune response to group A Streptococcus (GAS) infection resulting in the damage of heart valves. RHD is the most commonly acquired heart disease among children and young adults with a global burden of over 40 million cases accounting for 306,000 deaths annually. Inflammation in the heart valves caused due to molecular mimicry between the GAS antigens and host cardiac proteins is facilitated by cytokines, cross-reactive antibodies and CD4+ T cells. The c...
Source: Acta Cardiologica - May 12, 2023 Category: Cardiology Authors: Gunavathy Nagarajan Ramajayam Govindan Maheshkumar Poomarimuthu Rathinavel Andiappan Sivakumar Elango Stalinraja Maruthamuthu Jayalakshmi Mariakuttikan Sony Kadiam Source Type: research
