Clinical and Laboratory Diagnosis of Exanthems Among Japanese Children Younger Than 6 Years Old in the Post-Measles-Rubella Vaccine Era
CONCLUSIONS: The most common causes of pediatric exanthems were noninfectious diseases and viral exanthema. PCR assay was instrumental for etiological diagnosis of nonspecific exanthems.PMID:37963264 | DOI:10.1097/INF.0000000000004175 (Source: Herpes)
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Masato Yasuda Kensuke Shoji Keiichi Tomita Yoshiko Uchida Satoko Uematsu Kazue Yoshida Naoko Kono Motoki Funatsu Isao Miyairi Source Type: research
Clinical and Laboratory Diagnosis of Exanthems Among Japanese Children Younger Than 6 Years Old in the Post-Measles-Rubella Vaccine Era
CONCLUSIONS: The most common causes of pediatric exanthems were noninfectious diseases and viral exanthema. PCR assay was instrumental for etiological diagnosis of nonspecific exanthems.PMID:37963264 | DOI:10.1097/INF.0000000000004175 (Source: Herpes)
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Masato Yasuda Kensuke Shoji Keiichi Tomita Yoshiko Uchida Satoko Uematsu Kazue Yoshida Naoko Kono Motoki Funatsu Isao Miyairi Source Type: research
Incidence and aetiology of Danish children with community-acquired pneumonia treated with chest tube drainage in 2022-2023 versus the previous three decades
An emergence of complicated pneumonia due to invasive group A Streptococcus (GAS) was reported in 2022–2023.1 We aimed to explore the incidence and cause of complicated community-acquired pneumonia treated with chest tube drainage (CTD) in 2022–2023, compared with the preceding three decades. We retrospectively enrolled all patients aged 0–17 years treated with CTD due to community-acquired pneumonia from 1993–1994 to 2022–2023 at Copenhagen University Hospital, Rigshospitalet, a tertiary referral centre for CTD in Eastern Denmark, the Faroe Islands and Greenland (2.6 million inhabitants). Dat...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Nygaard, U., Bloch, J., Dungu, K. H. S., Vollmond, C., Buchvald, F. F., Nielsen, K. G., Kristensen, K., Poulsen, A., Vissing, N. H. Tags: Open access PostScript Source Type: research
Mediastinitis secondary to invasive infection by group A Streptococcus in Spain
Conclusion: mediastinistis is a rare but severe complication of iGAS and a high level of suspicion is required to diagnose it.What is Known:• Group A Streptococcus can cause invasive and severe infections in children.• Mediastinitis is a severe complication from some bacterial infections, mainly secondary due to deep-neck abscesses.What is New:• Mediastinitis is an unrecognized complication due to an invasive group A Streptococcus (iGAS) infection.• In cases of a deep-neck abscess or complicated pneumonia a high clinical suspicion of iGAS mediastinitis is required, especially when the clinical course is not favorab...
Source: European Journal of Pediatrics - October 27, 2023 Category: Pediatrics Source Type: research
Late Breaking Abstract - Fibrinolytics use in children with pleural empyema
Fibrinolytics are not yet routinely used in addition to chest drainage in children with pleural empyema. We assessed the number of children with empyema in which video assisted thoracoscopy (VATS) could be avoided in a centre where standard therapy is drainage using a chest drain with/without intrapleural fibrinolytics. We included all children referred for chest drainage of a pleural effusion to RadboudUMC between January 2022 and April 2023. Children were referred in case of pneumonia with respiratory distress and suspected pleural effusion on the chest X-ray or an effusion size >20mm in the chest ultrasound, indicati...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: de Jong, C. C. M., Heijting, I. E., Merkus, P. J. F. M., Roukema, J., Van Den Wijngaart, L. S., Pourier, M. S. Tags: Paediatric respiratory infection and immun. Source Type: research
Increased rates of invasive bacterial disease in late 2022
Conclusion: Invasive bacterial diseases increased in Q4 2022 with higher morbidity and mortality than in the preceding 4 years. Group A streptococcal infection was the most significant organism in 2022.What is known:• Invasive bacterial disease is the leading cause of childhood mortality globally.• There was an increase in cases of invasive Group A streptococcus infections reported in many countries (including Ireland) during the winter of 2022/23.What is new:• Head, neck and chest abscesses increased in Q4 of 2022 compared to the previous 4 years combined.• Invasive bacterial infections in Q4 of 2022 were assoc...
Source: European Journal of Pediatrics - October 26, 2023 Category: Pediatrics Source Type: research
Group A Streptococcus Primary Peritonitis in Children, New Zealand
Emerg Infect Dis. 2023 Nov;29(11). doi: 10.3201/eid2911.230211.ABSTRACTGroup A Streptococcus (GAS) primary peritonitis is a rare cause of pediatric acute abdomen (sudden onset of severe abdominal pain); only 26 pediatric cases have been reported in the English language literature since 1980. We discuss 20 additional cases of pediatric primary peritonitis caused by GAS among patients at Starship Children's Hospital, Auckland, New Zealand, during 2010-2022. We compare identified cases of GAS primary peritonitis to cases described in the existing pediatric literature. As rates of rates of invasive GAS increase globally, clini...
Source: Emerging Infectious Diseases - October 25, 2023 Category: Infectious Diseases Authors: Amanda Taylor Brodie M Elliott John Atkinson Sally Roberts Lesley Voss Emma J Best Rachel Webb Source Type: research
Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023
Emerg Infect Dis. 2023 Nov;29(11):2390-2392. doi: 10.3201/eid2911.230857.ABSTRACTAn increase in invasive group A Streptococcus infection was detected in the northeast of Spain in November 2022. A postpandemic decline in the diversity of circulating emm types involved in invasive group A Streptococcus was observed, along with the emergence of emm49 in this geographic area.PMID:37877666 | DOI:10.3201/eid2911.230857 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 25, 2023 Category: Infectious Diseases Authors: Alba Bell és-Bellés N úria Prim Saray Mormeneo-Bayo Pilar Villal ón-Panzano M ónica Valiente-Novillo Alfredo Jover-S áenz N úria Aixalà Albert Bernet Éric López-González Ivan Prats Merc è García-González Source Type: research
Group A Streptococcus Primary Peritonitis in Children, New Zealand
Emerg Infect Dis. 2023 Nov;29(11). doi: 10.3201/eid2911.230211.ABSTRACTGroup A Streptococcus (GAS) primary peritonitis is a rare cause of pediatric acute abdomen (sudden onset of severe abdominal pain); only 26 pediatric cases have been reported in the English language literature since 1980. We discuss 20 additional cases of pediatric primary peritonitis caused by GAS among patients at Starship Children's Hospital, Auckland, New Zealand, during 2010-2022. We compare identified cases of GAS primary peritonitis to cases described in the existing pediatric literature. As rates of rates of invasive GAS increase globally, clini...
Source: Emerging Infectious Diseases - October 25, 2023 Category: Infectious Diseases Authors: Amanda Taylor Brodie M Elliott John Atkinson Sally Roberts Lesley Voss Emma J Best Rachel Webb Source Type: research
Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023
Emerg Infect Dis. 2023 Nov;29(11):2390-2392. doi: 10.3201/eid2911.230857.ABSTRACTAn increase in invasive group A Streptococcus infection was detected in the northeast of Spain in November 2022. A postpandemic decline in the diversity of circulating emm types involved in invasive group A Streptococcus was observed, along with the emergence of emm49 in this geographic area.PMID:37877666 | DOI:10.3201/eid2911.230857 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 25, 2023 Category: Infectious Diseases Authors: Alba Bell és-Bellés N úria Prim Saray Mormeneo-Bayo Pilar Villal ón-Panzano M ónica Valiente-Novillo Alfredo Jover-S áenz N úria Aixalà Albert Bernet Éric López-González Ivan Prats Merc è García-González Source Type: research
Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A Streptococcus
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - October 24, 2023 Category: Infectious Diseases Authors: Shyra WildeAnanya DashAnders JohnsonKialani MackeyCheryl Y. M. OkumuraChristopher N. LaRock1Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, US Source Type: research
Group A Streptococcus Primary Peritonitis in Children, New Zealand
A. Taylor et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 16, 2023 Category: Infectious Diseases Source Type: research
B-lymphoblastic leukemia with transient spontaneous remission in the setting of severe group A streptococcus infection
AbstractSpontaneous remission of B-lymphoblastic leukemia (B-ALL) in the setting of viral and bacterial infections has been reported. Here, we present a case of B-ALL that showed a complete remission in the setting of group A streptococcal bacteremia. The patient was an 11-year-old boy who presented with a sore throat, right ear pain, and rhinorrhea. Prior to the diagnosis of B-ALL, he was diagnosed with streptococcal pharyngitis and received a single dose of dexamethasone and azithromycin. One day later, he was found to be pancytopenic and an immunophenotypically abnormal B-lymphoblastic population was detected comprising...
Source: Journal of Hematopathology - October 14, 2023 Category: Pathology Source Type: research
Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023
A. Bell és-Bellés et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 3, 2023 Category: Infectious Diseases Source Type: research
B-1 B Cell-Derived Natural Antibodies against N-Acetyl-d-Glucosamine Suppress Autoimmune Diabetes Pathogenesis
We report that neonatal immunization with group A Streptococcus suppresses T1D development in NOD mice by promoting clonal expansion of N-acetyl-d-glucosamine (GlcNAc)-specific B-1 B cells that recognize pancreatic β cell-derived Ags bearing GlcNAc-containing posttranslational modifications. Early exposure to Lancefield group A cell-wall carbohydrate Ags increased production of GlcNAc-reactive serum Abs and enhanced localization of innate-like GlcNAc-specific B cells to pancreatic tissue during T1D pathogenesis. We show that B-1 B cell-derived GlcNAc-specific IgM engages apoptosis-associated β cell Ags, thereby suppressi...
Source: Journal of Immunology - September 25, 2023 Category: Allergy & Immunology Authors: J Stewart New Brian L P Dizon R Glenn King Neil S Greenspan John F Kearney Source Type: research
