Emergence of Erythromycin-Resistant Invasive Group A Streptococcus, West Virginia, USA, 2020-2021
Emerg Infect Dis. 2023 May;29(5). doi: 10.3201/eid2905.221421.ABSTRACTClindamycin and β-lactam antibiotics have been mainstays for treating invasive group A Streptococcus (iGAS) infection, yet such regimens might be limited for strains displaying MLSB phenotypes. We investigated 76 iGAS isolates from 66 patients in West Virginia, USA, during 2020-2021. We performed emm typing using Centers for Disease Control and Prevention guidelines and assessed resistance both genotypically and phenotypically. Median patient age was 42 (range 23-86) years. We found 76% of isolates were simultaneously resistant to erythromycin and clind...
Source: Emerging Infectious Diseases - April 23, 2023 Category: Infectious Diseases Authors: Lillie M Powell Soo Jeon Choi Chloe E Chipman Megan E Grund P Rocco LaSala Slawomir Lukomski Source Type: research
Emergence of Erythromycin-Resistant Invasive Group A Streptococcus, West Virginia, USA, 2020-2021
Emerg Infect Dis. 2023 May;29(5). doi: 10.3201/eid2905.221421.ABSTRACTClindamycin and β-lactam antibiotics have been mainstays for treating invasive group A Streptococcus (iGAS) infection, yet such regimens might be limited for strains displaying MLSB phenotypes. We investigated 76 iGAS isolates from 66 patients in West Virginia, USA, during 2020-2021. We performed emm typing using Centers for Disease Control and Prevention guidelines and assessed resistance both genotypically and phenotypically. Median patient age was 42 (range 23-86) years. We found 76% of isolates were simultaneously resistant to erythromycin and clind...
Source: Emerging Infectious Diseases - April 22, 2023 Category: Infectious Diseases Authors: Lillie M Powell Soo Jeon Choi Chloe E Chipman Megan E Grund P Rocco LaSala Slawomir Lukomski Source Type: research
Emergence of Erythromycin-Resistant Invasive Group A Streptococcus, West Virginia, USA, 2020 –2021
L. M. Powell et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 14, 2023 Category: Infectious Diseases Source Type: research
Time to negative throat culture following initiation of antibiotics for pharyngeal group A Streptococcus: a systematic review and meta-analysis up to October 2021 to inform public health control measures
ConclusionsOur review provides evidence that antibiotics for pharyngeal GAS achieve a high rate of culture conversion within 24 h but highlights the need for further research given methodological limitations of published studies and imprecision of pooled estimates. Further evidence is needed for non-beta-lactam antibiotics and asymptomatic individuals. (Source: Eurosurveillance)
Source: Eurosurveillance - April 13, 2023 Category: Infectious Diseases Authors: Emma McGuire, Ang Li, Simon M Collin, Valerie Decraene, Michael Cook, Simon Padfield, Shiranee Sriskandan, Chris Van Beneden, Theresa Lamagni and Colin S Brown Source Type: research
Establishment of a Fast Diagnostic Method for Sepsis Pathogens Based on M1 Bead Enrichment
In this study, we established a fast diagnostic method using magnetic beads coated with human recombined mannose-binding lectin that makes it possible to concentrate pathogens from human plasma that have low concentrations of pathogens. With subsequent microculture (MC) and real-time PCR, this method allowed the detection of 1-10 CFUs/ml of Staphylococcus aureus, Group A Streptococcus, Escherichia coli, Pseudomonas aeruginosa, Candida tropicalis, or C. albicans from human plasma within 9.5 h, which was 21-80 h earlier than blood culture. The combination of pathogen enrichment and MC made the detection of sepsis-causing pat...
Source: Current Microbiology - April 6, 2023 Category: Microbiology Authors: Hao Zheng Xiaoli Chen Wenge Li Jinxing Lu Xiaoping Chen Source Type: research
Establishment of a Fast Diagnostic Method for Sepsis Pathogens Based on M1 Bead Enrichment
In this study, we established a fast diagnostic method using magnetic beads coated with human recombined mannose-binding lectin that makes it possible to concentrate pathogens from human plasma that have low concentrations of pathogens. With subsequent microculture (MC) and real-time PCR, this method allowed the detection of 1-10 CFUs/ml of Staphylococcus aureus, Group A Streptococcus, Escherichia coli, Pseudomonas aeruginosa, Candida tropicalis, or C. albicans from human plasma within 9.5 h, which was 21-80 h earlier than blood culture. The combination of pathogen enrichment and MC made the detection of sepsis-causing pat...
Source: Current Microbiology - April 6, 2023 Category: Microbiology Authors: Hao Zheng Xiaoli Chen Wenge Li Jinxing Lu Xiaoping Chen Source Type: research
Emerging Invasive Group A Streptococcus M1 < sub > UK < /sub > Lineage Detected by Allele-Specific PCR, England, 2020 < sup > 1 < /sup >
Emerg Infect Dis. 2023 Apr 5;29(5). doi: 10.3201/eid2905.221887. Online ahead of print.ABSTRACTIncreasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1UK. An allele-specific PCR was developed to distinguish M1UK from other emm1 strains. The M1UK lineage represented 91% of invasive emm1 isolates in England in 2020. Allele-specific PCR will permit surveillance for M1UK without need for genome sequencing.PMID:37019153 | DOI:10.3201/eid2905.221887 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 5, 2023 Category: Infectious Diseases Authors: Xiangyun Zhi Ho Kwong Li Hanqi Li Zuzanna Loboda Samson Charles Ana Vieira Kristin Huse Elita Jauneikaite Lucy Reeves Kai Yi Mok Juliana Coelho Theresa Lamagni Shiranee Sriskandan Source Type: research
Emerging Invasive Group A Streptococcus M1 < sub > UK < /sub > Lineage Detected by Allele-Specific PCR, England, 2020 < sup > 1 < /sup >
Emerg Infect Dis. 2023 Apr 5;29(5). doi: 10.3201/eid2905.221887. Online ahead of print.ABSTRACTIncreasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1UK. An allele-specific PCR was developed to distinguish M1UK from other emm1 strains. The M1UK lineage represented 91% of invasive emm1 isolates in England in 2020. Allele-specific PCR will permit surveillance for M1UK without need for genome sequencing.PMID:37019153 | DOI:10.3201/eid2905.221887 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 5, 2023 Category: Infectious Diseases Authors: Xiangyun Zhi Ho Kwong Li Hanqi Li Zuzanna Loboda Samson Charles Ana Vieira Kristin Huse Elita Jauneikaite Lucy Reeves Kai Yi Mok Juliana Coelho Theresa Lamagni Shiranee Sriskandan Source Type: research
Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 2020
X. Zhi et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 5, 2023 Category: Infectious Diseases Source Type: research
Addressing rheumatic fever inequities in Aotearoa New Zealand: a scoping review of prevention interventions
Discussion Although positive outcomes were reported for some interventions identified in this review, rheumatic fever rates have not shown any long-term reduction over time. Co-designing interventions with affected communities could ensure that strategies are better targeted and do not contribute to further stigma.PMID:37000539 | DOI:10.1071/HC22093 (Source: Journal of Primary Health Care)
Source: Journal of Primary Health Care - March 31, 2023 Category: Primary Care Authors: Siobhan Tu'akoi Malakai Ofanoa Samuela Ofanoa Hinamaha Lutui Maryann Heather Rawiri McKree Jansen Felicity Goodyear-Smith Source Type: research
Addressing rheumatic fever inequities in Aotearoa New Zealand: a scoping review of prevention interventions
Discussion Although positive outcomes were reported for some interventions identified in this review, rheumatic fever rates have not shown any long-term reduction over time. Co-designing interventions with affected communities could ensure that strategies are better targeted and do not contribute to further stigma.PMID:37000539 | DOI:10.1071/HC22093 (Source: Primary Care)
Source: Primary Care - March 31, 2023 Category: Primary Care Authors: Siobhan Tu'akoi Malakai Ofanoa Samuela Ofanoa Hinamaha Lutui Maryann Heather Rawiri McKree Jansen Felicity Goodyear-Smith Source Type: research
Addressing rheumatic fever inequities in Aotearoa New Zealand: a scoping review of prevention interventions
Discussion Although positive outcomes were reported for some interventions identified in this review, rheumatic fever rates have not shown any long-term reduction over time. Co-designing interventions with affected communities could ensure that strategies are better targeted and do not contribute to further stigma.PMID:37000539 | DOI:10.1071/HC22093 (Source: Journal of Primary Health Care)
Source: Journal of Primary Health Care - March 31, 2023 Category: Primary Care Authors: Siobhan Tu'akoi Malakai Ofanoa Samuela Ofanoa Hinamaha Lutui Maryann Heather Rawiri McKree Jansen Felicity Goodyear-Smith Source Type: research
Addressing rheumatic fever inequities in Aotearoa New Zealand: a scoping review of prevention interventions
Discussion Although positive outcomes were reported for some interventions identified in this review, rheumatic fever rates have not shown any long-term reduction over time. Co-designing interventions with affected communities could ensure that strategies are better targeted and do not contribute to further stigma.PMID:37000539 | DOI:10.1071/HC22093 (Source: Primary Care)
Source: Primary Care - March 31, 2023 Category: Primary Care Authors: Siobhan Tu'akoi Malakai Ofanoa Samuela Ofanoa Hinamaha Lutui Maryann Heather Rawiri McKree Jansen Felicity Goodyear-Smith Source Type: research
Addressing rheumatic fever inequities in Aotearoa New Zealand: a scoping review of prevention interventions
Discussion Although positive outcomes were reported for some interventions identified in this review, rheumatic fever rates have not shown any long-term reduction over time. Co-designing interventions with affected communities could ensure that strategies are better targeted and do not contribute to further stigma.PMID:37000539 | DOI:10.1071/HC22093 (Source: Journal of Primary Health Care)
Source: Journal of Primary Health Care - March 31, 2023 Category: Primary Care Authors: Siobhan Tu'akoi Malakai Ofanoa Samuela Ofanoa Hinamaha Lutui Maryann Heather Rawiri McKree Jansen Felicity Goodyear-Smith Source Type: research
