The associations between invasive group A streptococcal disease and infection with influenza, varicella or hepatitis C viruses: A data linkage study, Victoria, Australia

Invasive group A streptococcal disease (iGAS) is a rare and life-threatening infection. It occurs when group A Streptococcus bacteria (GAS, Streptococcus pyogenes) invade otherwise sterile sites of the body, such as the blood and cerebrospinal fluid.[1] Globally, it is estimated that 15 –25% of iGAS cases are fatal.[1] Severe manifestations such as sepsis, streptococcal toxic shock syndrome (STSS) and necrotising fasciitis have higher case fatality rates, even in well-resourced settings.[1, 2] iGAS is managed with antibiotics, and often requires surgery and supportive care for or gan dysfunction.[2] However, patients frequently experience rapid clinical progression and urgent medical attention is critical.[2] It is imperative that the factors that increase the risk of iGAS are well understood to support early diagnosis and rapid institution of life-saving medical care.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research