(What ’s the story) morning glory? MRI findings in morning glory disc anomaly
ConclusionThis study represents a comprehensive radiological-led investigation into MGDA. It describes the most frequently-encountered MRI findings in MGDA and emphasizes the importance of MRI in this cohort, i.e., in distinguishing MGDA from other posterior globe abnormalities, in assessing the visual pathway, and in screening for associated intracranial abnormalities – skull base/cerebral, vascular, and facial. It hypothesizes neurocristopathy as an underlying cause of MGDA and its associations. Caliber abnormalities of the ipsilateral optic nerve and chiasm are a frequent finding in MGDA. Optic pathway enlargement sho...
Source: Neuroradiology - May 8, 2024 Category: Radiology Source Type: research
Paracentral acute middle maculopathy and cotton wool spots in a patient with ocular migraine: A case report
In this study, we report paracentral acute middle maculopathy (PAMM) and cotton wool spots (CWS) in a patient with ocular migraine. A 74-year-old man presented with persistent paracentral scotoma in the right eye that began a week prior. His visual acuity was 20/25 in the right eye and 20/40 in the left. Dilated fundoscopy revealed CWS in the right eye. Spectral-domain optical coherence tomography (SD-OCT) showed hyper-reflective bands in the inner nuclear layer corresponding to parafoveal lesions seen on near-infrared imaging in the right eye consistent with the diagnosis of PAMM. Further laboratory studies were unremarka...
Source: European Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: MacGregor N Hall Arash Maleki Source Type: research
Paracentral acute middle maculopathy and cotton wool spots in a patient with ocular migraine: A case report
In this study, we report paracentral acute middle maculopathy (PAMM) and cotton wool spots (CWS) in a patient with ocular migraine. A 74-year-old man presented with persistent paracentral scotoma in the right eye that began a week prior. His visual acuity was 20/25 in the right eye and 20/40 in the left. Dilated fundoscopy revealed CWS in the right eye. Spectral-domain optical coherence tomography (SD-OCT) showed hyper-reflective bands in the inner nuclear layer corresponding to parafoveal lesions seen on near-infrared imaging in the right eye consistent with the diagnosis of PAMM. Further laboratory studies were unremarka...
Source: European Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: MacGregor N Hall Arash Maleki Source Type: research
Paracentral acute middle maculopathy and cotton wool spots in a patient with ocular migraine: A case report
In this study, we report paracentral acute middle maculopathy (PAMM) and cotton wool spots (CWS) in a patient with ocular migraine. A 74-year-old man presented with persistent paracentral scotoma in the right eye that began a week prior. His visual acuity was 20/25 in the right eye and 20/40 in the left. Dilated fundoscopy revealed CWS in the right eye. Spectral-domain optical coherence tomography (SD-OCT) showed hyper-reflective bands in the inner nuclear layer corresponding to parafoveal lesions seen on near-infrared imaging in the right eye consistent with the diagnosis of PAMM. Further laboratory studies were unremarka...
Source: European Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: MacGregor N Hall Arash Maleki Source Type: research
Genes, Vol. 15, Pages 516: Syndromic Retinitis Pigmentosa: A 15-Patient Study
This study reviewed the clinical data of 15 patients with syndromic retinitis pigmentosa from a Rare Disease Reference Center in Brazil and the results of their next-generation sequencing tests. Five males and ten females participated, with the mean ages for ocular disease onset, fundoscopic diagnosis, and molecular evaluation being 9, 19, and 29 years, respectively. Bardet–Biedl syndrome (n = 5) and Usher syndrome (n = 3) were the most frequent diagnoses, followed by other rare conditions. Among the patients, fourteen completed molecular studies, with three negative results and eleven revealing findings in k...
Source: Genes - April 20, 2024 Category: Genetics & Stem Cells Authors: Ianne Pessoa Holanda Priscila Hae Hyun Rim Rare Genomes Project Consortium Rare Genomes Project Consortium Mara Sanches Guaragna Vera L úcia Gil-da-Silva-Lopes Carlos Eduardo Steiner Tags: Case Report Source Type: research
Anterior and posterior ischemic optic neuropathy in a child with focal segmental glomerulosclerosis on hemodialysis
ConclusionsThe exact cause of our patient ’s simultaneous bilateral anterior and posterior ION, confirmed via MRI and fundoscopic examination, is unclear; however, is likely secondary to a combination of fluctuating blood pressure, anemia, anephric status, and hemodialysis. This highlights the need for close blood pressure monitoring, man agement of anemia, and more diligent ophthalmologic screening in pediatric patients on chronic hemodialysis. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research
Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | PMC:PMC11012611 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research
C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration
ConclusionIntermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 3, 2024 Category: Allergy & Immunology Source Type: research
Orbital infarction syndrome following mechanical thrombectomy in internal carotid artery occlusion: a case report
ConclusionOrbital ischemic syndrome is a rare complication after mechanical thrombectomy treatment in acute ischemic stroke that can lead to loss of visual acuity. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 8, 2024 Category: General Medicine Source Type: research
Circle of Willis
A man in his 50s with a history of squamous cell carcinoma of the tongue with cervical lymph node involvement after radiotherapy presented to an ophthalmologist with intermittent visual changes. His neurologic examination yielded normal results. Fundoscopy revealed cotton wool spots bilaterally, concerning for ischemic retinopathy. Computed tomographic angiography of the neck revealed chronic complete occlusions of the bilateral common carotid arteries and the left vertebral artery. Magnetic resonance imaging of the brain showed multiple bihemispheric watershed infarcts. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 7, 2024 Category: Internal Medicine Authors: Nitesh P. Patel, Lorenzo Rinaldo, Giuseppe Lanzino Tags: Medical image Source Type: research
Differentiating stages of functional vision loss from glaucoma using the Disc Damage Likelihood Scale and cup:disc ratio
Conclusion
This study indicates that both structural staging systems can differentiate severe/end-stage glaucoma from less severe disease, with a moderate advantage of DDLS over CDR. Clinical examination of the optic disc plays an important role in addition to functional assessment when managing severe/end-stage glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Philippin, H., Matayan, E. N., Knoll, K. M., Macha, E., Mbishi, S., Makupa, A., Matsinhe, C. D., da Gama, I. V., Monjane, M. J., Ncheda, J. A., Mulobuana, F. A. F., Muna, E., Guylene, N. F., Gazzard, G., Marques, A. P., Shah, P., Macleod, D., Makupa, W., Tags: Open access Glaucoma Source Type: research
A hypomorphic variant of choroideremia is associated with a novel intronic mutation that leads to exon skipping
DISCUSSION: Mild choroideremia may result from +3 or -3 splice site variants in CHM. It is presumed that the resulting mRNA transcripts may be partly functional, thereby preventing the development of the null phenotype. Choroideremia patients with such variants may present challenges for gene therapy since there may be residual transcript activity which could result in long-lasting visual function which is atypical for this disease.PMID:38273808 | DOI:10.1080/13816810.2023.2270554 (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - January 26, 2024 Category: Opthalmology Authors: William J Waldock Laura J Taylor Sian Sperring Federica Staurenghi Cristina Martinez-Fernandez de la Camara Jennifer Whitfield Penny Clouston Imran H Yusuf Robert E MacLaren Source Type: research
Suppressor of cytokine signaling 3-derived peptide as a therapeutic for inflammatory and oxidative stress-induced damage to the retina
CONCLUSIONS: R9-SOCS3-KIR blocks the induction of inflammatory signaling in cell culture and reduces retinal damage in a widely used RPE/retinal oxidative injury model. As this peptide can be administered through corneal instillation, this treatment may offer a convenient way to slow down the progression of ocular diseases arising from inflammation and chronic oxidative stress.PMID:38264613 | PMC:PMC10805335 (Source: Molecular Vision)
Source: Molecular Vision - January 24, 2024 Category: Molecular Biology Authors: Chulbul M Ahmed Anil P Patel Howard M Johnson Cristhian J Ildefonso Alfred S Lewin Source Type: research
