Efficacy and Safety of CSF-1 (0.4% Pilocarpine Hydrochloride) in Presbyopia: Pooled Results of the NEAR Phase 3 Randomized, Clinical Trials
This study was undertaken to evaluate the safety and efficacy of CSF-1 (0.4% pilocarpine hydrochloride ophthalmic solution) for use in individuals with presbyopia.METHODS: Two Phase 3 multicenter, randomized, double-masked, vehicle-controlled, parallel-group clinical trials were conducted in 35 private ophthalmology clinics in the United States from October 2020 to February 2022. Key inclusion criteria were the following: (1) age 45-64 years, (2) distance-corrected near visual acuity (DCNVA) at 40 cm ≥0.40 and ≤0.90 logarithm of the minimum angle of resolution (logMAR, approximately 20/50-20/160 Snellen) in at least 1 ...
Source: Clinical Therapeutics - January 12, 2024 Category: Drugs & Pharmacology Authors: Edward Holland Paul Karpecki Murray Fingeret Jack Schaeffer Preeya Gupta Nicole Fram Gerard Smits Teresa Ignacio Richard Lindstrom Source Type: research
Torpedo-Makulopathie: Fallserienpr äsentation einer unterdiagnostizierten seltenen Erkrankung unter Verwendung multimodaler Bildgebung
CONCLUSION: Torpedo maculopathy is a rare well described clinical condition that displays pathognomonic features on regular fundoscopy examination. Our case series showed that the use of multimodal imaging, including SD-OCT, FAF and OCTA, seems to be of little value in increasing its recognition thus confirming the importance of its typical clinical appearance among ophthalmologists. Interestingly, SD-OCT and OCTA demonstrated no abnormalities of the adjacent macula of the affected eye, which seems to confirm its isolated local unilateral ophthalmic condition.PMID:38176433 | DOI:10.1055/a-2238-7245 (Source: Klinische Monat...
Source: Klinische Monatsblatter fur Augenheilkunde - January 4, 2024 Category: Opthalmology Authors: Nicolas Owlya Mickael Barbosa Anna Chiara Nascimbeni Yannic Pannatier-Schuetz Daniela Gallo Castro Aude Ambresin Source Type: research
Long-term follow-up of a bilateral acute posterior multifocal placoid pigment epitheliopathy following COVID-19 infection: a case report
ConclusionCOVID-19 might cause long-lasting activity of APMPPE. The scarcity of reports compared with the number of confirmed COVID-19 infections worldwide suggests a rare entity. The association of APMPPE with a variety of infections may suggest a common immunological aberrant response that might be triggered by various factors. Further examinations and case reports are needed to understand the role of biological therapy in the treatment of such cases. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - January 4, 2024 Category: Opthalmology Source Type: research
Establishment and visual analysis of CBA/J-Pde6b < sup > Y347Y/Y347X < /sup > and C3H/HeJ-Pde6b < sup > Y347Y/Y347X < /sup > mice
Exp Anim. 2023 Dec 28. doi: 10.1538/expanim.23-0142. Online ahead of print.ABSTRACTIn CBA/J and C3H/HeJ mice, retinitis pigmentosa is inherited as an autosomal-recessive trait due to a mutation in Pde6b, which encodes cGMP phosphodiesterase subunit b. In these strains, the Y347X mutation in Pde6b leads to the upregulation of cGMP levels, increased Ca2+ influx induces rod death, and the outer segment and rod cells entirely disappeared by 35 days after birth. In the present study, we utilized the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas)9-mediated gene editing to repair the Y34...
Source: Experimental Animals - January 3, 2024 Category: Research Authors: Miyuki Shindo Miho Terao Shuji Takada Minoru Ichinose Emiko Matsuzaka Tadashi Yokoi Noriyuki Azuma Seiya Mizuno Hideki Tsumura Source Type: research
