Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas
Abstract
Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N–F fluorinating agent that is reactive towards neutral enol species.
Beilstein J. Org. Chem. 2024, 20, 460–469. doi:10.3762/bjoc.20.41 (Source: Beilstein Journal of Organic Chemistry)
Source: Beilstein Journal of Organic Chemistry - February 28, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: difluorination difluoromethylene direct fluorination electrophilic fluorination organofluorine Full Research Paper Source Type: research
Rosuvastatin effect on atherosclerotic plaque metabolism: A subclinical atherosclerosis imaging study with 18F –NaF PET-CT
Atherosclerotic plaque fluorine-18 sodium fluoride (18F –NaF) uptake on positron emission tomography with computed tomography (PET-CT) identifies active microcalcification and has been shown to correlate with clinical instability in patients with cardiovascular (CV) disease. Statin therapy promotes coronary macrocalcification over time. Our aim was to investigate rosuvastatin effect on atheroma 18F–NaF uptake. (Source: Atherosclerosis)
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Manuel Oliveira-Santos, Jo ão Borges-Rosa, Rodolfo Silva, Luís Paixão, Cláudio Espírito Santo, Antero Abrunhosa, Miguel Castelo-Branco, Lino Gonçalves, Maria João Ferreira, Piotr J. Slomka Source Type: research
Boosting CO < sub > 2 < /sub > chemical fixation over MOF-808 by the introduction of functional groups and defective Zr sites
Chem Commun (Camb). 2024 Feb 27. doi: 10.1039/d3cc06154j. Online ahead of print.ABSTRACTCO2 cycloaddition has emerged as a promising approach for producing value-added cyclocarbonates and mitigating greenhouse gas emissions. Although MOF-808 serves as a stable catalyst for cycloaddition, its limited activity constrains broader applications. Through the modification with a fluoride group via a ligand exchange method, F-MOF-808-1.5 exhibits exceptional performance, achieving a 98.8% conversion with 97.8% selectivity to epichlorohydrin carbonate-marking a substantial 100% improvement compared to pristine MOF-808. The defectiv...
Source: Chemical Communications - February 27, 2024 Category: Chemistry Authors: Minghui Zhou Zhengyan Qu Jiuxuan Zhang Hong Jiang Zhenchen Tang Rizhi Chen Source Type: research
Impact of COVID-19 pandemic on pediatric dental procedures in primary healthcare settings in Piracicaba, Brazil: an ecological study
CONCLUSIONS: The COVID-19 pandemic has hindered access to primary dental care for children, impacting the quantity of emergency care, reducing restorations of deciduous teeth, and first programmed dental consultations. These findings highlight the need for strategies to ensure that pediatric dental care is not neglected during pandemics.PMID:38413864 | DOI:10.1186/s12875-024-02315-6 (Source: Primary Care)
Source: Primary Care - February 27, 2024 Category: Primary Care Authors: R úbia Vanessa Figueiredo Dos Santos Fernanda Maria Rovai Bado Inara Pereira da Cunha Marcelo de Castro Meneghim Source Type: research
Boosting CO < sub > 2 < /sub > chemical fixation over MOF-808 by the introduction of functional groups and defective Zr sites
Chem Commun (Camb). 2024 Feb 27. doi: 10.1039/d3cc06154j. Online ahead of print.ABSTRACTCO2 cycloaddition has emerged as a promising approach for producing value-added cyclocarbonates and mitigating greenhouse gas emissions. Although MOF-808 serves as a stable catalyst for cycloaddition, its limited activity constrains broader applications. Through the modification with a fluoride group via a ligand exchange method, F-MOF-808-1.5 exhibits exceptional performance, achieving a 98.8% conversion with 97.8% selectivity to epichlorohydrin carbonate-marking a substantial 100% improvement compared to pristine MOF-808. The defectiv...
Source: Chemical Communications - February 27, 2024 Category: Chemistry Authors: Minghui Zhou Zhengyan Qu Jiuxuan Zhang Hong Jiang Zhenchen Tang Rizhi Chen Source Type: research
Metabolome evidence of CKDu risks after chronic exposure to simulated Sri Lanka drinking water in zebrafish
This study aimed to investigate the risks of various environmental factors that may induce CKDu, including water hardness, fluoride (HF), heavy metals (HM), microcystin-LR (MC-LR), and their combined exposure (HFMM). The research focused on comprehensive metabolome analysis, and correlation with transcriptomic and gut microbiota changes. Results revealed that chronic exposure led to kidney damage and pancreatic toxicity in adult zebrafish. Metabolomics profiling showed significant alterations in biochemical processes, with enriched metabolic pathways of oxidative phosphorylation, folate biosynthesis, arachidonic acid metab...
Source: Ecotoxicology and Environmental Safety - February 27, 2024 Category: Environmental Health Authors: Pan-Pan Jia Yan Li Lan-Chen Zhang Ming-Fei Wu Tian-Yun Li De-Sheng Pei Source Type: research
Metabolome evidence of CKDu risks after chronic exposure to simulated Sri Lanka drinking water in zebrafish
This study aimed to investigate the risks of various environmental factors that may induce CKDu, including water hardness, fluoride (HF), heavy metals (HM), microcystin-LR (MC-LR), and their combined exposure (HFMM). The research focused on comprehensive metabolome analysis, and correlation with transcriptomic and gut microbiota changes. Results revealed that chronic exposure led to kidney damage and pancreatic toxicity in adult zebrafish. Metabolomics profiling showed significant alterations in biochemical processes, with enriched metabolic pathways of oxidative phosphorylation, folate biosynthesis, arachidonic acid metab...
Source: Ecotoxicology and Environmental Safety - February 27, 2024 Category: Environmental Health Authors: Pan-Pan Jia Yan Li Lan-Chen Zhang Ming-Fei Wu Tian-Yun Li De-Sheng Pei Source Type: research
Bio ‐Inspired Interlocking Structures for Enhancing Flexible Coatings Adhesion
Inspired by the intricate interdigitated structures inPhloeodes diabolicus elytra, a straightforward magnetic molding technique is employed to create an interlocking microarray for enhancing interfacial adhesion between low surface energy polymeric coatings, especially elastomeric materials, and rigid substances. This innovative method holds tremendous potential for strengthening both rigid-flexible, flexible-flexible, and low surface energy interfaces, offering broad applications across multitude fields. AbstractThe flexible protective coatings and substrates frequently exhibit unstable bonding in industrial applications....
Source: Small - February 27, 2024 Category: Nanotechnology Authors: Pengpeng Lu,
Xin Li,
Jingyang Xu,
Yong Fan,
Jiyu Sun,
Yunhong Liang,
Limei Tian,
Weihua Ming,
Luquan Ren,
Jie Zhao Tags: Research Article Source Type: research
PVDF ‐HFP Based, Quasi‐Solid Nanocomposite Electrolytes for Lithium Metal Batteries
Robust and highly performing poly(vinylidene fluoride-co-hexafluoropropylene)-based composite membranes, as electrolytes for Lithium Metal Batteries are obtained by means of functionalized SiO2 nanofillers. Proper functionalization improves the thermal, microstructural mechanical and transport properties of the membranes and allows improved full cell behavior with LiFePO4 based cathode. AbstractComposite polymer electrolytes are systems of choice for future solid-state lithium metal batteries (LMBs). Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) is among the most interesting matrices to develop new generation...
Source: Small - February 27, 2024 Category: Nanotechnology Authors: Eleonora Carena,
Lorenzo Mezzomo,
Nicholas Vallana,
Nicole Ceribelli,
Giovanni Di Liberto,
Silvia Mostoni,
Chiara Ferrara,
Michele Mauri,
Roberto Lorenzi,
Livia Giordano,
Riccardo Ruffo,
Piercarlo Mustarelli Tags: Research Article Source Type: research
Development of magnetic La doped Al < sub > 2 < /sub > O < sub > 3 < /sub > core-shell nanoparticle loaded hydrogel for selective recovery of fluoride from aquatic medium
Chemosphere. 2024 Feb 23:141504. doi: 10.1016/j.chemosphere.2024.141504. Online ahead of print.ABSTRACTThe selective removal of pollutants from water bodies is regarded as a conciliation between the rapid expansion of industrial activities and need of clean water for sustainability. Fluoride is one such geogenic pollutant, and various materials have already been reported. Developing an efficient field employable material is however a challenge. Herein, we report the synthesis and competencies of strategically designed magnetic La-doped Al2O3 core-shell nanoparticle loaded polymeric nanohybrid as a benchmark fluoride sorben...
Source: Chemosphere - February 25, 2024 Category: Chemistry Authors: Hirakendu Basu M Amarnath Brindaban Modak Harshala Parab Ranita Basu Sakshi Goyal Sudeshna Saha Shweta Singh Chandra Nath Patra Source Type: research
Development of magnetic La doped Al < sub > 2 < /sub > O < sub > 3 < /sub > core-shell nanoparticle loaded hydrogel for selective recovery of fluoride from aquatic medium
Chemosphere. 2024 Feb 23:141504. doi: 10.1016/j.chemosphere.2024.141504. Online ahead of print.ABSTRACTThe selective removal of pollutants from water bodies is regarded as a conciliation between the rapid expansion of industrial activities and need of clean water for sustainability. Fluoride is one such geogenic pollutant, and various materials have already been reported. Developing an efficient field employable material is however a challenge. Herein, we report the synthesis and competencies of strategically designed magnetic La-doped Al2O3 core-shell nanoparticle loaded polymeric nanohybrid as a benchmark fluoride sorben...
Source: Chemosphere - February 25, 2024 Category: Chemistry Authors: Hirakendu Basu M Amarnath Brindaban Modak Harshala Parab Ranita Basu Sakshi Goyal Sudeshna Saha Shweta Singh Chandra Nath Patra Source Type: research
Development of magnetic La doped Al < sub > 2 < /sub > O < sub > 3 < /sub > core-shell nanoparticle loaded hydrogel for selective recovery of fluoride from aquatic medium
Chemosphere. 2024 Feb 23:141504. doi: 10.1016/j.chemosphere.2024.141504. Online ahead of print.ABSTRACTThe selective removal of pollutants from water bodies is regarded as a conciliation between the rapid expansion of industrial activities and need of clean water for sustainability. Fluoride is one such geogenic pollutant, and various materials have already been reported. Developing an efficient field employable material is however a challenge. Herein, we report the synthesis and competencies of strategically designed magnetic La-doped Al2O3 core-shell nanoparticle loaded polymeric nanohybrid as a benchmark fluoride sorben...
Source: Chemosphere - February 25, 2024 Category: Chemistry Authors: Hirakendu Basu M Amarnath Brindaban Modak Harshala Parab Ranita Basu Sakshi Goyal Sudeshna Saha Shweta Singh Chandra Nath Patra Source Type: research
Development of magnetic La doped Al < sub > 2 < /sub > O < sub > 3 < /sub > core-shell nanoparticle loaded hydrogel for selective recovery of fluoride from aquatic medium
Chemosphere. 2024 Feb 23:141504. doi: 10.1016/j.chemosphere.2024.141504. Online ahead of print.ABSTRACTThe selective removal of pollutants from water bodies is regarded as a conciliation between the rapid expansion of industrial activities and need of clean water for sustainability. Fluoride is one such geogenic pollutant, and various materials have already been reported. Developing an efficient field employable material is however a challenge. Herein, we report the synthesis and competencies of strategically designed magnetic La-doped Al2O3 core-shell nanoparticle loaded polymeric nanohybrid as a benchmark fluoride sorben...
Source: Chemosphere - February 25, 2024 Category: Chemistry Authors: Hirakendu Basu M Amarnath Brindaban Modak Harshala Parab Ranita Basu Sakshi Goyal Sudeshna Saha Shweta Singh Chandra Nath Patra Source Type: research
Community water fluoride cessation and rate of caries-related pediatric dental treatments under general anesthesia in Alberta, Canada
CONCLUSION: Discontinuing water fluoridation appears to negatively affect young children's oral health, potentially leading to a significant increase in caries-related dental treatments under GA and oral health disparities in this pediatric population.PMID:38389035 | DOI:10.17269/s41997-024-00858-w (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - February 23, 2024 Category: International Medicine & Public Health Authors: Elnaz Yazdanbakhsh Babak Bohlouli Steven Patterson Maryam Amin Source Type: research
Community water fluoride cessation and rate of caries-related pediatric dental treatments under general anesthesia in Alberta, Canada
CONCLUSION: Discontinuing water fluoridation appears to negatively affect young children's oral health, potentially leading to a significant increase in caries-related dental treatments under GA and oral health disparities in this pediatric population.PMID:38389035 | DOI:10.17269/s41997-024-00858-w (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - February 23, 2024 Category: International Medicine & Public Health Authors: Elnaz Yazdanbakhsh Babak Bohlouli Steven Patterson Maryam Amin Source Type: research
