Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine
Emerg Infect Dis. 2024 Apr;30(4):738-751. doi: 10.3201/eid3004.231141. Epub 2024 Mar 13.ABSTRACTHighly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and mammals across North America. Continued circulation in birds and infection of multiple mammalian species with strains possessing adaptation mutations increase the risk for infection and subsequent reassortment with influenza A viruses endemic in swine. We assessed the susceptibility ...
Source: Emerging Infectious Diseases - March 13, 2024 Category: Infectious Diseases Authors: Bailey Arruda Amy L Vincent Baker Alexandra Buckley Tavis K Anderson Mia Torchetti Nichole Hines Bergeson Mary Lea Killian Kristina Lantz Source Type: research
Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine
Emerg Infect Dis. 2024 Apr;30(4):738-751. doi: 10.3201/eid3004.231141. Epub 2024 Mar 13.ABSTRACTHighly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and mammals across North America. Continued circulation in birds and infection of multiple mammalian species with strains possessing adaptation mutations increase the risk for infection and subsequent reassortment with influenza A viruses endemic in swine. We assessed the susceptibility ...
Source: Emerging Infectious Diseases - March 13, 2024 Category: Infectious Diseases Authors: Bailey Arruda Amy L Vincent Baker Alexandra Buckley Tavis K Anderson Mia Torchetti Nichole Hines Bergeson Mary Lea Killian Kristina Lantz Source Type: research
CDC Eases Isolation Guidance for Respiratory Viruses
New guidance from the US Centers for Disease Control and Prevention (CDC) provides updated measures to combat respiratory viruses such as SARS-CoV-2, influenza, and respiratory syncytial virus. The recommendations come at a time when deaths and hospitalizations from COVID-19 have decreased from the peak of the pandemic and the availability of tools to fight respiratory viruses is greater than ever, the agency noted. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 13, 2024 Category: General Medicine Source Type: research
Vaccine Development
This article considers ethical considerations surrounding pediatric vaccine development for pandemic preparedness, examines some historical cases of pediatric vaccines developed during past smallpox, influenza, and 2019 coronavirus disease pandemics, and discusses the current state of vaccine development for pandemic preparedness, including vaccines against smallpox/mpox, influenza, anthrax, and Ebola that are included in the US Strategic National Stockpile and vaccines being developed against priority pathogens identified by the World Health Organization. (Source: Pediatric Clinics of North America)
Source: Pediatric Clinics of North America - March 12, 2024 Category: Pediatrics Authors: Elizabeth A.D. Hammershaimb, James D. Campbell Source Type: research
Changes in Attitudes and Barriers to Seasonal Influenza Vaccination from 2007 to 2023
This study investigated how factors and barriers to flu vaccination among college students has changed over the past 16 years. Data were collected from 440 students using a survey and compared to previous data from the same university. Respondents were also asked about their experiences with Covid-19 and its effect on their intent to vaccinate. We found that vaccination rates had increased from 12.4 to 30.5%. Among the unvaccinated, expense, fear of getting influenza from vaccination, fear of side effects, and lack of information have decreased by 28%, 20%, 17%, and 15% respectively. Time, convenience, and perceived risk a...
Source: Journal of Community Health - March 11, 2024 Category: International Medicine & Public Health Source Type: research
Pandemic antecedents - Exploring predictivity and relationships between COVID-19 vaccine uptake and influenza, shingles, and HPV vaccination
CONCLUSION: Experience with COVID-19 vaccination and the relationship of those experiences with other vaccinations provide useful insight on leveraging vaccine uptake. Healthcare professionals should improve the COVID-19 vaccination experience and use vaccination appointments to promote other vaccinations. Research should continue to compare vaccination experiences and how they may persuade or dissuade vaccination intent for other vaccinations.PMID:38461049 | DOI:10.1016/j.vaccine.2024.03.003 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Monique Luisi Mugur V Geana Jun Pei Source Type: research
Pandemic antecedents - Exploring predictivity and relationships between COVID-19 vaccine uptake and influenza, shingles, and HPV vaccination
CONCLUSION: Experience with COVID-19 vaccination and the relationship of those experiences with other vaccinations provide useful insight on leveraging vaccine uptake. Healthcare professionals should improve the COVID-19 vaccination experience and use vaccination appointments to promote other vaccinations. Research should continue to compare vaccination experiences and how they may persuade or dissuade vaccination intent for other vaccinations.PMID:38461049 | DOI:10.1016/j.vaccine.2024.03.003 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Monique Luisi Mugur V Geana Jun Pei Source Type: research
High-Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer-Antigen Recognition in Clinical Samples and Machine Learning
Angew Chem Int Ed Engl. 2024 Mar 8:e202400413. doi: 10.1002/anie.202400413. Online ahead of print.ABSTRACTHigh-precision viral detection at point of need with clinical samples plays a pivotal role in the diagnosis of infectious diseases and the control of a global pandemic. However, the complexity of clinical samples that often contain very low viral concentrations makes it a huge challenge to develop simple diagnostic devices that do not require any sample processing and yet are capable of meeting performance metrics such as very high sensitivity and specificity. Herein we describe a new single-pot and single-step electro...
Source: Angewandte Chemie - March 8, 2024 Category: Chemistry Authors: Payel Sen Zijie Zhang Sadman Sakib Jimmy Gu Wantong Li Bal Ram Adhikari Ariel Motsenyat Jonathan L'Heureux-Hache Jann C Ang Gurpreet Panesar Bruno J Salena Debora Yamamura Matthew S Miller Leyla Soleymani Yingfu Li Source Type: research
Omics-based profiles and biomarkers of respiratory infections: are we there yet?
Extract
From the influenza pandemic of 1918–1919 to the most recent COVID-19 pandemic, respiratory infections remain a leading cause of mortality worldwide [1, 2]. Concurrently, the development of high-throughput omics technologies has revolutionised research about host responses to known and emerging respiratory pathogens [3], accelerating our understanding of highly prevalent pulmonary diseases [4]. Notably, omics technology-based characterisation of pathogens and host pathophysiology have critically supported diagnostic and therapeutic global health efforts during both the influenza A H1N1 and SARS-CoV-2 pandemics...
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Pantaleon Garcia, J., Evans, S. E. Tags: Editorials Source Type: research
The 1919-21 influenza pandemic in Greenland
Int J Circumpolar Health. 2024 Dec;83(1):2325711. doi: 10.1080/22423982.2024.2325711. Epub 2024 Mar 6.ABSTRACTIn Alaska, the 1918-20 influenza pandemic was devastating, with mortality rates up to 90% of the population, while in other arctic regions in northern Sweden and Norway mortality was considerably lower. We investigated the timing and age-patterns in excess mortality in Greenland during the period 1918-21 and compare these to other epidemics and the 1889-92 pandemic. We accessed the Greenlandic National Archives and transcribed all deaths from 1880 to 1921 by age, geography, and cause of death. We estimated monthly ...
Source: International Journal of Circumpolar Health - March 6, 2024 Category: International Medicine & Public Health Authors: Mathias M ølbak Ingholt Lone Simonsen Svenn-Erik Mamelund Paneeraq Noahsen Maarten van Wijhe Source Type: research
The 1919-21 influenza pandemic in Greenland
Int J Circumpolar Health. 2024 Dec;83(1):2325711. doi: 10.1080/22423982.2024.2325711. Epub 2024 Mar 6.ABSTRACTIn Alaska, the 1918-20 influenza pandemic was devastating, with mortality rates up to 90% of the population, while in other arctic regions in northern Sweden and Norway mortality was considerably lower. We investigated the timing and age-patterns in excess mortality in Greenland during the period 1918-21 and compare these to other epidemics and the 1889-92 pandemic. We accessed the Greenlandic National Archives and transcribed all deaths from 1880 to 1921 by age, geography, and cause of death. We estimated monthly ...
Source: International Journal of Circumpolar Health - March 6, 2024 Category: International Medicine & Public Health Authors: Mathias M ølbak Ingholt Lone Simonsen Svenn-Erik Mamelund Paneeraq Noahsen Maarten van Wijhe Source Type: research
Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
Non-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally. The absence of influenza has raised concerns of waning immunity, and p... (Source: Virology Journal)
Source: Virology Journal - March 6, 2024 Category: Virology Authors: Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad and Olav Hungnes Tags: Research Source Type: research
Viruses, Vol. 16, Pages 404: Changes in Prevalence and Seasonality of Pathogens Identified in Acute Respiratory Tract Infections in Hospitalised Individuals in Rural and Urban Settings in South Africa; 2018 & ndash;2022
Viruses, Vol. 16, Pages 404: Changes in Prevalence and Seasonality of Pathogens Identified in Acute Respiratory Tract Infections in Hospitalised Individuals in Rural and Urban Settings in South Africa; 2018–2022
Viruses doi: 10.3390/v16030404
Authors:
Michaela Davids
Siobhan Johnstone
Adriano Mendes
Gadean Brecht
Theunis Avenant
Nicolette du du Plessis
Maryke de de Villiers
Nicola Page
Marietjie Venter
Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others o...
Source: Viruses - March 5, 2024 Category: Virology Authors: Michaela Davids Siobhan Johnstone Adriano Mendes Gadean Brecht Theunis Avenant Nicolette du du Plessis Maryke de de Villiers Nicola Page Marietjie Venter Tags: Article Source Type: research
