Association of viral loads of influenza A(H3N2) with age and care setting on presentation – a prospective study during the 2022/23 influenza season in Spain.
Since the precise significance of viral load (VL) test for the management and treatment of patients with respiratory viruses remains unknown, it is not a commonly used tool. However, since the COVID-19 pandemic, VL evaluation has gained popularity in the scientific community and healthcare providers due to the possible application in daily clinical practice and research [1 –3]. During the worst part of the pandemic, when hospitalization was overcrowded and a huge need for resources was the most important issue, the Ct value (Cycle threshold), a subrogate of the VL, was used as a criterion for discharging patients. (Sourc...
Source: International Journal of Infectious Diseases - March 30, 2024 Category: Infectious Diseases Authors: Iv án Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Irene Arroyo-Hernantes, Marta Domínguez-Gil, Silvia Rojo-Rello, Marta Hernández, José M Eiros Source Type: research
Viruses, Vol. 16, Pages 533: Prevalence of Respiratory Viral Infections in Deceased Persons during the COVID-19 Pandemic Season 2021 & ndash;2022: A Population-Based Observational Study
Viruses, Vol. 16, Pages 533: Prevalence of Respiratory Viral Infections in Deceased Persons during the COVID-19 Pandemic Season 2021–2022: A Population-Based Observational Study
Viruses doi: 10.3390/v16040533
Authors:
Camino Trobajo-Sanmartín
Ana Navascués
Miguel Fernández-Huerta
Iván Martínez-Baz
Itziar Casado
Carmen Ezpeleta
Jesús Castilla
Although the omicron variant of SARS-CoV-2 circulated intensely during the 2021–2022 season, many patients with severe acute respiratory disease tested negative for COVID-19. The aim of this study was to assess the presence of different...
Source: Viruses - March 29, 2024 Category: Virology Authors: Camino Trobajo-Sanmart ín Ana Navascu és Miguel Fern ández-Huerta Iv án Martínez-Baz Itziar Casado Carmen Ezpeleta Jes ús Castilla Tags: Article Source Type: research
Leveraging seasonal influenza health worker vaccination programmes for COVID-19 vaccine Introduction: A global qualitative analysis
CONCLUSIONS: Our findings suggest a strong justification for enhanced investment in vaccination of health workers, particularly against seasonal influenza, through country-wide programmes as a foundation for pandemic preparedness and response.PMID:38531724 | DOI:10.1016/j.vaccine.2023.12.044 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Anna-Maria Volkmann Shoshanna Goldin Britney McMurren Claire Gapare Beth Anne Pratt Laura Frost Shalini Desai Source Type: research
Leveraging seasonal influenza health worker vaccination programmes for COVID-19 vaccine Introduction: A global qualitative analysis
CONCLUSIONS: Our findings suggest a strong justification for enhanced investment in vaccination of health workers, particularly against seasonal influenza, through country-wide programmes as a foundation for pandemic preparedness and response.PMID:38531724 | DOI:10.1016/j.vaccine.2023.12.044 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Anna-Maria Volkmann Shoshanna Goldin Britney McMurren Claire Gapare Beth Anne Pratt Laura Frost Shalini Desai Source Type: research
Cross-sectional study of influenza trends and costs in Malaysia between 2016 and 2018
ConclusionsThe study provides valuable insights into the dynamic landscape of influenza in Malaysia. The findings reveal a consistent year-round presence of influenza with irregular seasonal peaks, including a notable influenza A epidemic in 2017 and consistent surges in influenza B incidence during March across three years. These findings underscore the significance of continuous monitoring influenza subtypes for informed healthcare strategies as well as advocate for the integration of influenza vaccination into Malaysia ’s national immunization program, enhancing overall pandemic preparedness. (Source: PLoS One)
Source: PLoS One - March 22, 2024 Category: Biomedical Science Authors: Sharifa Ezat Wan Puteh Source Type: research
Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned
Pediatr Res. 2024 Mar 20. doi: 10.1038/s41390-024-03145-z. Online ahead of print.ABSTRACTPregnant individuals with viral illness may experience significant morbidity and have higher rates of pregnancy and neonatal complications. With the growing number of viral infections and new viral pandemics, it is important to examine the effects of infection during pregnancy on both the gestational parent and the offspring. Febrile illness and inflammation during pregnancy are correlated with risk for autism, attention deficit/hyperactivity disorder, and developmental delay in the offspring in human and animal models. Historical vira...
Source: Pediatric Research - March 21, 2024 Category: Pediatrics Authors: Emma F Yates Sarah B Mulkey Source Type: research
Changes in Attitudes and Barriers to Seasonal Influenza Vaccination from 2007 to 2023
This study investigated how factors and barriers to flu vaccination among college students has changed over the past 16 years. Data were collected from 440 students using a survey and compared to previous data from the same university. Respondents were also asked about their experiences with Covid-19 and its effect on their intent to vaccinate. We found that vaccination rates had increased from 12.4 to 30.5%. Among the unvaccinated, expense, fear of getting influenza from vaccination, fear of side effects, and lack of information have decreased by 28%, 20%, 17%, and 15% respectively. Time, convenience, and perceived risk a...
Source: Journal of Community Health - March 21, 2024 Category: International Medicine & Public Health Source Type: research
Strengthening Pediatric and Public Health Collaboration to Protect Children ’s Health During a Pandemic
This article examines lessons learned from previous pandemics, including the 2009 H1N1 influenza and the coronavirus disease 2019 pandemic. Pediatric providers have a unique and important role and strategies to improve collaboration and communication between public health and pediatric providers are essential during public health emergencies. A robust network of communication channels, effective public health messaging, and pediatric-focused disease related, and program outcome data are key to supporting a coordinated response to future pandemics. Critical issues include real-time communication with and engagement of pedia...
Source: Pediatric Clinics of North America - March 21, 2024 Category: Pediatrics Authors: Zanah K. Francis, Elizabeth M. Dufort, Bernadette A. Albanese, Wendy M. Chung, Ellen H. Lee, Zack Moore, Laurene Mascola, Erica Pan, Caitlin Pedati, George Turabelidze, Sarah Y. Park Source Type: research
AE-GPT: Using Large Language Models to extract adverse events from surveillance reports-A use case with influenza vaccine adverse events
by Yiming Li, Jianfu Li, Jianping He, Cui Tao
Though Vaccines are instrumental in global health, mitigating infectious diseases and pandemic outbreaks, they can occasionally lead to adverse events (AEs). Recently, Large Language Models (LLMs) have shown promise in effectively identifying and cataloging AEs within clinical reports. Utilizing d ata from the Vaccine Adverse Event Reporting System (VAERS) from 1990 to 2016, this study particularly focuses on AEs to evaluate LLMs’ capability for AE extraction. A variety of prevalent LLMs, including GPT-2, GPT-3 variants, GPT-4, and Llama2, were evaluated using Influenza vacc...
Source: PLoS One - March 21, 2024 Category: Biomedical Science Authors: Yiming Li Source Type: research
Establishing Pandemic Influenza Severity Assessment (PISA) parameters and thresholds for Canada's FluWatch program
CONCLUSION: With confidence in the validity of the PISA thresholds, the FluWatch program will begin to share PISA assessments weekly through the FluWatch report in the 2023-2024 seasons to help characterize influenza activity in Canada and inform responses to the seasonal influenza epidemic.PMID:38504879 | PMC:PMC10946583 | DOI:10.14745/ccdr.v49i1112a04 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 20, 2024 Category: Infectious Diseases Authors: FluWatch Team1 Source Type: research
Syndromic surveillance performance in Canada throughout the COVID-19 pandemic, March 1, 2020 to March 4, 2023
This article examines the performance of FluWatchers' syndromic surveillance over the three years of the COVID-19 pandemic in Canada. More specifically, this article examines FluWatchers' performance with respect to the correlation between the FluWatchers influenza-like illness (ILI) and acute respiratory infection (ARI) indicators and total respiratory virus detections (RVDs) in Canada, including influenza, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and other respiratory viruses.PMID:38504875 | PMC:PMC10946582 | DOI:10.14745/ccdr.v49i1112a06 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 20, 2024 Category: Infectious Diseases Authors: Myriam Ben Moussa Abbas Rahal Liza Lee Shamir Mukhi Source Type: research
Mucosal immunization with dual influenza/COVID-19 single-replication virus vector protects hamsters from SARS-CoV-2 challenge
Vaccine. 2024 Mar 19:S0264-410X(24)00327-X. doi: 10.1016/j.vaccine.2024.03.040. Online ahead of print.ABSTRACTThe COVID-19 pandemic has highlighted the need for mucosal vaccines as breakthrough infections, short-lived immune responses and emergence of new variants have challenged the efficacy provided by the first generation of vaccines against SARS-CoV-2 viruses. M2SR SARS-CoV-2, an M2-deleted single-replication influenza virus vector modified to encode the SARS-CoV-2 receptor binding domain, was evaluated following intranasal delivery in a hamster challenge model for protection against Wuhan SARS-CoV-2. An adjuvanted ina...
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Lindsay Hill-Batorski Richard Bowen Helle Bielefeldt-Ohmann Michael J Moser Sarah M Matejka David Marshall Yoshihiro Kawaoka Gabriele Neumann Pamuk Bilsel Source Type: research
Establishing Pandemic Influenza Severity Assessment (PISA) parameters and thresholds for Canada's FluWatch program
CONCLUSION: With confidence in the validity of the PISA thresholds, the FluWatch program will begin to share PISA assessments weekly through the FluWatch report in the 2023-2024 seasons to help characterize influenza activity in Canada and inform responses to the seasonal influenza epidemic.PMID:38504879 | PMC:PMC10946583 | DOI:10.14745/ccdr.v49i1112a04 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 20, 2024 Category: Infectious Diseases Authors: FluWatch Team1 Source Type: research
Syndromic surveillance performance in Canada throughout the COVID-19 pandemic, March 1, 2020 to March 4, 2023
This article examines the performance of FluWatchers' syndromic surveillance over the three years of the COVID-19 pandemic in Canada. More specifically, this article examines FluWatchers' performance with respect to the correlation between the FluWatchers influenza-like illness (ILI) and acute respiratory infection (ARI) indicators and total respiratory virus detections (RVDs) in Canada, including influenza, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and other respiratory viruses.PMID:38504875 | PMC:PMC10946582 | DOI:10.14745/ccdr.v49i1112a06 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 20, 2024 Category: Infectious Diseases Authors: Myriam Ben Moussa Abbas Rahal Liza Lee Shamir Mukhi Source Type: research
A computational approach to design a multiepitope vaccine against H5N1 virus
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the poultry business. The rapid rate of mutation of H5N1 viruses makes the who... (Source: Virology Journal)
Source: Virology Journal - March 20, 2024 Category: Virology Authors: Fatemeh Dashti, Arash Raisi, Ghazaleh Pourali, Zahra Sadat Razavi, Fatemeh Ravaei, Javid Sadri Nahand, Fatemeh Kourkinejad-Gharaei, Seyed Mohammad Ali Mirazimi, Javad Zamani, Hossein Tarrahimofrad, Seyed Mohammad Reza Hashemian and Hamed Mirzaei Tags: Research Source Type: research
