Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
As suicide and gun violence rise, we need gun purchase waiting periods now
In 2018, physicians began #ThisIsOurLane, a movement arguing that gun violence is a public health epidemic that medical professionals have a vital role in dismantling. Gun suicide rates are increasing across America – particularly in states with the fewest gun laws. Guns are the most lethal method of self-harm, with a fatality rate of 90%,
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As suicide and gun violence rise, we need gun purchase waiting periods now originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 19, 2023 Category: General Medicine Authors: Taytum Kahl Tags: Policy Public Health & Policy Source Type: blogs
Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Raised Remnant Cholesterol Level Correlates with Frailty
Remnant cholesterol refers to circulating cholesterol in the bloodstream that is not attached to LDL transport particles coming from the liver or HDL transport particles going to the liver. The remnant is attached to some mix of VLDL and IDL particles that serve much the same purpose as LDL particles, or incorporated into much larger chylomicron transporters that carry dietary lipids from the intestines throughout the body.
Researchers have noted that remnant cholesterol appears to contribute to cardiovascular risk, speeding the progression of atherosclerosis and increasing the risk of stroke and heart attack. It is...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
CAP2 Expression Correlates with Frailty, Not Chronological Age
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Survivors of Nuclear Weapon Use in Early Life Exhibit Accelerated Immune Aging in Late Life
It probably strains the meaning of the term to call the aftermath of the use of nuclear weapons at the end of the Second World War a natural experiment, but nonetheless there has been considerable study of survivors from those events and their health relative to control populations in other parts of Japan. Irradiation is known to produce what is effectively accelerated aging in the context of cancer treatment, producing an increased burden of senescent cells that then ensure the later course of health for survivors is worse than would otherwise be the case, absent both cancer and treatment. In the case of exposure to radia...
Source: Fight Aging! - August 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Familial Longevity is Accompanied by Increased Healthspan
In this study we showed that members of long-lived families have a delayed onset of disease, multimorbidity, and medication use as compared to their partners, thereby extending their healthspan with up to a decade. These members also postponed multimorbidity since those who were already diagnosed with an age-related disease had a 54% lower risk of having a second age-related disease compared to their partners.
An increasing number of long-lived ancestors, as measured with the Longevity Relatives Count (LRC) score, not only associates with a lower mortality at any moment in life it also associates, in a similar way,...
Source: Fight Aging! - August 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Little Mermaid ’ s impact on storytelling [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Erkeda DeRouen, a family physician, as we delve into the recent remake of The Little Mermaid. Discover how this Disney film led Erkeda on a journey to explore the inspiring story of Howard Ashman, his battle with HIV during the AIDS epidemic, and
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The Little Mermaid’s impact on storytelling [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 10, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Public Health & Policy Source Type: blogs
Why Artificial Intelligence Will Fuel Fake News (M)
An infodemic is an epidemic-like circulation of fake news, videos and images that is highly contagious and grows exponentially. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 6, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Artificial intelligence subscribers-only Source Type: blogs
Visually Guided Uterine Biopsies in Physician ’s Office: Interview with Allison London Brown, CEO of LUMINELLE
LUMINELLE, a medtech company based in North Carolina, has developed a suite of endoscopic tools that allow clinicians to perform visually guided gynecological procedures right from their office. At present, the majority of uterine biopsies taken to investigate the cause of abnormal uterine bleeding are taken blind, with no visual guidance at all. This leads to suboptimal outcomes, and the frequent need to repeat the biopsy procedure because the first attempt did not yield an adequate sample.
To address this, LUMINELLE has developed the LUMINELLE SUSTAINE system and the LUMINELLE Bx (Biopsy) device. These technologies ar...
Source: Medgadget - August 4, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ob/Gyn Source Type: blogs
Study Warns That Even Light Drinking Can Raise Blood Pressure
Conclusion
In sum, the international research study underscores the significant impact of alcohol consumption on blood pressure, with effects noticed even at low levels. Contrary to common assumptions, it highlights no beneficial effects in low-level drinkers compared to non-drinkers.
The findings serve as a crucial reminder of the importance of moderation, or ideally, avoidance of alcohol for effective blood pressure management and optimal cardiovascular health. The global scale and comprehensive approach of the study lend weight to its findings, making them a key resource for individuals worldwide.
In the face o...
Source: The EMT Spot - August 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Environmental Health Surveillance Powered by GIS Technology Enhances Public Health Efforts at San Bernardino County
San Bernadino Public Health knows that monitoring the mosquito population benefits community health directly. This is why the public health team is tracking mosquitos breeding areas and leveraging GIS technology to better coordinate mosquito control efforts in order to prevent the spread of disease.
Healthcare IT Today spoke with Serene Ong – Geographic Information Systems Analyst, Andrew Mackey – Statistical Analyst, and Anthony Arce – Research Analyst at San Bernardino County Department of Public Health (SBCDPH) to find out more.
Mosquito Surveillance
Mosquito Surveillance is used to monitor mosquito po...
Source: EMR and HIPAA - August 1, 2023 Category: Information Technology Authors: Colin Hung Tags: Analytics/Big Data Health IT Company Healthcare IT Andrew Mackey Anthony Arce ArcGIS esri GIS technology Mosquito Surveillance Public Health San Bernardino County San Bernardino County Department of Public Health SBCDPH Serene On Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A comic reveals the terrifying truth about fentanyl
The fentanyl crisis represents a grave and lethal epidemic, marked by the illicit consumption of powerful synthetic opioids, resulting in a staggering increase in fatal overdose cases. Physician Emily Watters offers her unique insights on this critical issue through a captivating comic format (click to enlarge): Emily Watters is a psychiatrist and can be reached
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A comic reveals the terrifying truth about fentanyl originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 27, 2023 Category: General Medicine Authors: Emily Watters, MD Tags: Meds Psychiatry Source Type: blogs
