Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 953: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19, protection against Omicron from vaccination and […] (Source: virology blog)
Source: virology blog - November 12, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid marburg virus monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 953: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19, protection against Omicron from vaccination and … TWiV 953: Clinical update with Dr. Daniel Griffin Read More » (Source: virology blog)
Source: virology blog - November 12, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid marburg virus monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Good Law to Fight Bad Bugs: Legal Responses to Epidemics
Carol A. Heimer (Northwestern University), Clay Davis (Northwestern University), Good Law to Fight Bad Bugs: Legal Responses to Epidemics, 18 Ann. Rev. L.& Sco. Sci. 1 (2022): Although epidemics are generally understood as lying within the domain of biomedicine,... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - November 9, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Does High Blood Pressure Make You Tired, Sleepy?
This article will help shed light on the link.
Quick Summary
There is a strong link between feeling tired or sleepy with high blood pressure due to underlying conditions or medication.
Kidney disease, arterial disease, and sleep apnea are possible explanations for lethargy with hypertension.
Proper treatment and control can reduce the risk of fatigue caused by elevated blood pressure.
So, Does High Blood Pressure Make You Feel Tired, Sleepy, or Fatigued?
Fatigue and high blood pressure are connected, but they could also be a symptom of underlying causes—for example, hypertension medication...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Caffeine in Coffee: How Does It Affect Your Blood Pressure?
Coffee is a daily essential to kick-start most people’s days. But did you know caffeine in coffee can affect blood pressure in hypertensive patients?
With its annual consumption of nearly 8.6 billion kgs, coffee is a must-have for most people. If you regularly enjoy a cup of java, you must be familiar with the energetic buzz that sets in shortly after your first sips.
For some, even just the aroma of coffee is enough to give you a boost. However, scientists often debate whether drinking coffee regularly benefits your cardiovascular health and blood pressure, or the opposite.
Find out if your daily cup of cof...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Connecting IGF1 Signaling and Cellular Senescence
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Link: https://doi.org/10.3390/cells11203260 ...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Has Omics Data Taught Us About Dementia?
An enormous amount of biological data can now be obtained from any given study population, and at reasonable cost. The resulting databases have grown to become very large. The epigenome, transcriptome, proteome, metabolome, microbiome, and much more, are at the fingertips of every epidemiological researcher, at multiple time points, before and after interventions, and at different ages. It is easy enough to find differences in the data between more healthy subjects and patients suffering from one or more age-related conditions. It is a harder task to build upon that data in order to find useful therapies. Aging causes swee...
Source: Fight Aging! - November 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Control of Blood Pressure Reduces Dementia Risk
Raised blood pressure produces damage to tissues throughout the body. That control of blood pressure via antihypertensive drugs, forcing better function without addressing any of the underlying causative damage of aging, does in fact reduce mortality in later life is a compelling indication of the degree to which raised blood pressure is directly harmful. In the brain, manifestations of this harm include an acceleration of the processes of atherosclerosis, disruption of the blood-brain barrier leading to brain inflammation, and an increase in the pace at which capillaries and other small vessels rupture, all of this damage...
Source: Fight Aging! - November 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MIDAS and IQ Inc. Partner to Develop Software to Protect Patients by Preventing Medication Diversion by Healthcare Providers
The MIDAS V.I.E.W. system will prevent diversion of controlled substances and other dangerous medications in healthcare settings across the country
MIDAS Healthcare Solutions Inc., the leading developer of technology-driven solutions to promote the safe use, handling, storage, return, and disposal of controlled substances and other dangerous medications in hospitals and other healthcare facilities, announced today a $1.19 million investment from IQ Inc., an award-winning software development firm that creates innovative people-focused solutions across a variety of services and industries, including healthcare.
This partne...
Source: EMR and HIPAA - October 31, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT ASAM Barbara VanKirk Becton Dickinson DEA Dr. Andrea Barthwell Drug Enforcement Administration Health IT Funding Health IT Fundings Health IT Investment IHFDA IQ IQ Inc. Jeffrey R. Wahl Medicat Source Type: blogs
Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metaboli...
Source: Fight Aging! - October 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Age of Metabolomics
Obtaining enormous amounts of data on the human metabolome now costs little. Databases of metabolomic data available for analysis have become vast, and continue to grow. Productive analysis trails far behind the production of data, unfortunately, as is true for all of the omics technologies. In this paper, researchers discuss the present state of metabolomic knowledge in the context of aging, and the path forward to producing useful understanding from this deluge of human data, contributing perhaps to the better development of treatments for aging.
Aging is a fundamental part of the human experience, and it has lo...
Source: Fight Aging! - October 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
October 27, 2022 Edition-----In the UK we have a political farce running with only a day or so to run when you read this, with a new PM (Rishi Sunak) in place..In the US the mid-term elections are coming in a week or so, thus some concern as to where the US is going!In China Xi has his third 5 year term so we all wonder how that will turn out!In OZ we have has a Budget with floods, inflation, data leaks, the threat of recession, Medicare concerns and other issues just rolling on! At least the Budget does not seem to have broken anything!Overall an ‘omnishambles’ as they say!-----Major Issues.-----https://www.afr.com/wo...
Source: Australian Health Information Technology - October 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Does Surviving The Plague Mean You Will Eventually Contract An Autoimmune Disease?
BY MIKE MAGEE
This Fall, I am teaching a 4-week course on “How Epidemics Have Shaped Our World” at the President’s College at the University of Hartford. It is, of course a timely topic, but also personally unnerving as we complete a third year under the shadow of Covid-19.
Where does one begin on a topic such as this? Yale historian, Frank M. Snowden, in his book “Epidemics and Society: From the Black Death to the Present”, made his intentions obvious. He would begin with the plaque. Why? His answer, “The word ‘plague’ will always be synonymous with ‘terror’”, and especially references:
...
Source: The Health Care Blog - October 26, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Autoimmune. Disease Mike Magee Plague Source Type: blogs
