Further Evidence for Reduced Blood Pressure to Lower Risk of Dementia
The raised blood pressure of hypertension causes a great deal of downstream damage. It is a way for low-level biochemical damage associated with aging to become actual physical damage to the body. Pressure damage can occur in delicate tissues throughout the body, and raised blood pressure increases the pace at which capillaries and other small vessels rupture. Further, increased blood pressure can accelerate the development of atherosclerosis, and also contributes to the pathological enlargement and weakening of heart muscle. All of this downstream harm is why forcing a reduction in blood pressure, without addressing any o...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Are clinicians complicit in the Fentanyl epidemic?
I have a friend. He is non-medical, just a person who knows a lot of people. He grew up on the rough side of town. He has lost five friends or relatives this past year, he tells me. All to Fentanyl overdoses. Most were young, in their twenties or thirties. Two were friends of his
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Are clinicians complicit in the Fentanyl epidemic? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 19, 2023 Category: General Medicine Authors: Janet Tamaren, MD Tags: Meds Pain Management Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cardiovascular Aging Correlates with Brain Aging
Many large epidemiological studies demonstrate a correlation between cardiovascular aging and the risk of suffering cognitive decline and dementia. The population size of such studies has increased in recent years with the advent of sizable national databases, such as the UK Biobank. Today's open access paper focuses on one specific aspect of cardiovascular aging, the onset of atrial fibrillation, irregular heartbeats that can be accompanied by palpitations and other worrying sensations. Atrial fibrillation can arise in combination with many of the features of cardiovascular aging, and one might argue that data on time of ...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
TikTok on the Gender Gap
By MIKE MAGEE
The juxta-positioning of Tuesday’s New York Times headlines was disturbing. The first “Why Does This Bride Look So Mad?”, was followed by “An ‘Unsettling’ Drop in Life Expectancy in Men.”
The “reluctant bride” referred to in the first article is (by now) an estimated 175 years old intended bride was 18 in the painting. The painting itself was the work of artist, Auguste Toulmouche, in 1866. The original title was “The Hesitant Fiancee”. Its current fame has a much shorter timeline – 2 weeks to be exact. That’s when it began to appear on TikTok, hosted as a statement of disg...
Source: The Health Care Blog - November 15, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Gender gap Life Expectancy Mike Magee tiktok Source Type: blogs
Answer to Case 731
Answer to theParasite Case of the Week 731:Echinococcussp. protoscolex. Hopefully you all got to look at it moving! Given that this is a single liver cyst, it would fit withE. granulosus. Correlation with radiologic and epidemiologic features would be helpful for confirmation.Here are some of the key diagnostic features: (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 14, 2023 Category: Parasitology Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The critical link between America ’ s obesity epidemic and the liver
Obesity has undeniably become the top health issue of our time, with its prevalence and impact on our bodies making headlines across health care and popular media. This isn’t merely a matter of carrying extra pounds; it’s about the multitude of serious health complications that come in its wake. The conversation around obesity often gravitates
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The critical link between America’s obesity epidemic and the liver originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 3, 2023 Category: General Medicine Authors: Darryn Potosky, MD Tags: Conditions Gastroenterology Source Type: blogs
The Coalition for Epidemic Preparedness Innovations (CEPI) and the Partnerships of Equitable Vaccine Access
Sam Halabi (O ’Neill Institute), Lawrence O. Gostin (Georgetown University), Kashish Aneja (Georgetown University), Francesca Nardi (Georgetown University), et al., The Coalition for Epidemic Preparedness Innovations (CEPI) and the Partnerships of Equitable Vaccine Access, 51 J. of L. Med.& Ethics... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - October 31, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Some Like It Hot! A Century-Old Disease on Our Southern Shores
By MIKE MAGEE
Naomi Orestes PhD, Professor of the History of Science at Harvard, didn’t mince words as she placed our predicament in context when she said, “If you know your Greek tragedies you know power, hubris, and tragedy go hand in hand. If we don’t address the harmful aspects of human activities, most obviously disruptive climate change, we are headed for tragedy.”
At the time, as a member of the Anthropocene Workgroup, she and a group of international climate scientists were focused on defining and measuring nine “planetary boundaries,” environmental indicators of planetary health. At...
Source: The Health Care Blog - October 30, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Avian Flu Climate Change Pandemic Sea level change Yellow Fever Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sizable Mortality Risk Differences for Healthy versus Unhealthy Lifestyles in Later Life
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
Link: https://doi.org/10.1186/s12877-023-04247-9 (Source: Fight Aging!)
Source: Fight Aging! - October 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lifestyle Produces a Much Greater Contribution to Human Life Expectancy than a Genetic Risk Score
Since the advent of very large databases of combined human genetic and epidemiological information, the evidence has increasingly leaned to support only a modest effect of genetic variation on human life span variation. Setting aside small populations with rare mutations, lifestyle has a much greater effect on life expectancy than one's genes. Even cases of familial longevity might largely result from transmission of culture, and thus lifestyle choices, rather than transmission of genetic variants.
Today's open access paper reports on data in which both genetic risk and lifestyle risk can be assessed. It is worth no...
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Just say no
I just finished reading Dopesick, by Beth Macy. You don ' t need to take my word that it ' s worth your while, the book was a huge bestseller. However, it does have a fairly narrow focus. It tells the story of the opioid epidemic largely within the confines of a region of rural Virginia, but this is a disaster of national scope that manifests somewhat differently in different places. Here ' s the really sad news: source:U.S. Department of Health and Human Services I know it ' s a little small but you can see it full size if you click the link. The short version of the story is that deaths from opioid ...
Source: Stayin' Alive - October 17, 2023 Category: American Health Source Type: blogs
Aspects of Iron Metabolism Correlate with Epigenetic Age Acceleration
In conclusion, the results of the present investigation unveiled the causality of iron overload on acceleration of epigenetic clocks. Researches are warranted to illuminate the underlying mechanisms and formulate strategies for potential interventions.
Link: https://doi.org/10.1186/s13148-023-01575-w (Source: Fight Aging!)
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
