Mitochondrial Copy Number in Immune Cells Strongly Correlates with 15-Year Mortality
We examined a random population sample in 2003/2005 (n = 9,360, age 45-69, the HAPIEE project) and followed up for 15 years. Using a nested case-control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake, and education.
The age-sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 and 1.59; an increased risk ...
Source: Fight Aging! - July 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Matthew ’ s tidbits: Obesity Summer
Every time I get around to sending out the THCB READER I add a short & usually not to sweet commentary on some aspect of health care.–Matthew Holt
I saw the obesity crisis up close this week. And by that I’m not just referring to my addiction to Salted Caramel with Pretzel Ice Cream, bad though it is. Instead I felt thin because I went to Disneyland. But while I tip the scales at a BMI of 30 if I’m lucky, I genuinely felt that looking around Disneyland more than 50% of the crowd were obese and many morbidly so.
The rest of my trip to Southern California was quite a contrast because I’ve be...
Source: The Health Care Blog - July 24, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt obesity epidemic Ozempic Source Type: blogs
Spouse behavior as a coronary risk factor ?
This is a re-blog from 2010 pages of this site.
Hope we have more updates.Spouse behaviour as significant CAD risk factor, is still a valid research concept that shall lead to more productive social “cardiac Interventions” and prevent CAD burden outside the much glamorised cathlab
Dr.S.Venkatesan MD
American journal of epidemiology in a land mark analysis has found , spouses share the same profile of coronary risk factors .This is a huge finding , considering the fact that , genetic factors are not involved here . So , it is something to do with family diet ? domestic issues, sibling effect ?
It is well-k...
Source: Dr.S.Venkatesan MD - July 24, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Truthfully, the Physician Shortage Doesn ’ t Exist!
Conclusion: For every hour physicians provide direct clinical face time to patients, nearly 2 additional hours is spent on EHR and desk work within the clinic day. Outside office hours, physicians spend another 1 to 2 hours of personal time each night doing additional computer and other clerical work. (Sinsky et al, 2016)
If we only had the tools and the administrative support that just about every one of us has been asking for, there wouldn’t be a doctor shortage.
The quote here is from 7 years ago and things have gotten even worse since then.
Major league baseball players don’t handle the scoring and the st...
Source: The Health Care Blog - July 21, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Hans Duvefelt Physician Shortage Source Type: blogs
The Short-Term Economic Argument for Undertaking Efforts to Treat Aging as a Medical Condition
The primary economic argument presently made for treating aging as a medical condition emerges from the fact that medical spending and medical research is largely entwined with government in much of the world; it is increasingly a public purse, not a collection of private purses. Politicians and bureaucrats care (to some degree) about avoiding the looming financial implosion that will result when present unsustainable spending policies run head-on into the demographic transition to a society in which an ever-larger proportion of people are old, suffering from age-related disease, and many of their expenses paid via entitle...
Source: Fight Aging! - July 20, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
How Alcohol Affects Blood Pressure: A Detailed Insight
Conclusion
In this guide, we’ve explored the complex relationship between alcohol and blood pressure. We’ve seen that alcohol, whether consumed moderately, heavily, or in a binge pattern, can impact blood pressure.
We also delved into the biological mechanisms at play, the role of various drinking patterns, and the sobering revelations of recent research.
While the pleasure of a drink might be fleeting, its effects on our body, particularly on our blood pressure, can be long-lasting.
The key takeaway? Moderation. Even a small reduction in alcohol intake can have significant health benefits, partic...
Source: The EMT Spot - July 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
No, the Poor Don ’ t Always Have to Be With Us
BY KIM BELLARD
OK, for you amateur (or professional) epidemiologists among us: what are the leading causes of death in the U.S.? Let’s see, most of us would probably cite heart disease and cancer. After that, we might guess smoking, obesity, or, in recent years, COVID. But a new study has a surprising contender: poverty.
It’s the kind of thing you might expect to find in developing countries, not in the world’s leading economy, the most prosperous country in the world. But amidst all that prosperity, the U.S. has the highest rates of poverty among developed countries, which accounts in no small part ...
Source: The Health Care Blog - July 18, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Anti-Poverty Medicine Kim Bellard TANF Source Type: blogs
Microglial Activation as a Consequence of Gum Disease
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Food allergies are not preferences. Let ’s start treating them that way.
We’re in a rapidly growing food allergy epidemic. 1 in 13 American children have food allergies—a number that’s only growing. Private insurance claims of anaphylactic food reactions, which are severe and potentially life-threatening, rose 377 percent from 2007 to 2016. Yet despite their increased prevalence in recent years, one thing hasn’t changed: Undermining the very
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Food allergies are not preferences. Let’s start treating them that way. originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 14, 2023 Category: General Medicine Authors: David R. Stukus, MD and Anushree Vashist Tags: Conditions Allergies & Immunology Source Type: blogs
Mindlessness
Academy Health is the rather oddly named society for health services researchers. They sent me a press release which I excerpt: Today, the House Appropriations Committee released a
breathtakingly reckless bill that decimates federal research, science,
and medicine programs, and puts the health of all Americans at risk. It
is so extreme that many pundits presume it has zero chance of becoming
law, but that very extremism requires that we respond quickly and
unequivocally. . . . " This bill would eliminate the Agency for Healthcare
Research and Quality (AHRQ) in its entirety. AHRQ supports r...
Source: Stayin' Alive - July 14, 2023 Category: American Health Source Type: blogs
Mobilization for Truth, or Survival?
Scott Frickel, of my own university, and Fernando Tormos-Aponte of the University of Pittsburgh,have recently reviewed studies of what they call " science activism " and find that it is " surging, " which they refer to as a " culture shift " among scientists. They write:Science activism has long been considered taboo, as many in the field fear thatpoliticizing science undermines its objectivity.
Even so, scientist-activists have still managed to shape the U.S.
political landscape throughout history. Over the past century, for
example, scientists have protestedthe atomic bomb,pesticides,wars in Southeast Asia,genet...
Source: Stayin' Alive - July 10, 2023 Category: American Health Source Type: blogs
Longevity-Associated FLT1 Variant May Protect Against Hypertension Consequences
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Link: https://doi.org/10.18632/aging.204722 (Source: Fight Aging!)
Source: Fight Aging! - July 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The epidemic of narcissistic abuse in the medical field
I didn’t go through that to go through this. “She doesn’t know how to work within a system,” said Snakeskin Shoes. Narcissists grow and thrive in children’s hospitals. Their strategy is to inflict moral injury upon physicians by gaslighting and silencing those who speak up for patient safety or for themselves, while also controlling a
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The epidemic of narcissistic abuse in the medical field originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 7, 2023 Category: General Medicine Authors: Karla Lester, MD Tags: Physician Hospital-Based Medicine Source Type: blogs
