Uncovering the truth about racial health inequities in America: a book review
When I started my intern year, that is my first year of training in medical residency, I noticed something peculiar about the epidemiology of disease in our hospital. The Black patients on the medical wards would often present with the morbidity of their diseases almost ten to twenty years earlier than their white counterparts. A Read more… Uncovering the truth about racial health inequities in America: a book review originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 29, 2023 Category: General Medicine Authors: Tags: Policy Public Health & Policy Source Type: blogs

The hidden factor in physician burnout: How the climate crisis is contributing to the erosion of well-being
Anyone who practiced medicine in the past decade will be well acquainted with the myriad discussions about epidemic of burnout and the eroding of well-being among health care providers that has accelerated with the pandemic. With 63 percent of physicians having at least one symptom of burnout and professional fulfillment dropping from 40 to 20 Read more… The hidden factor in physician burnout: How the climate crisis is contributing to the erosion of well-being originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 28, 2023 Category: General Medicine Authors: Tags: Physician Public Health & Policy Source Type: blogs

The Myth of Stage 1 Pressure Injuries
The current body of knowledge surrounding pressure injuries is replete with myths that have been accepted as fact. A myth is defined as a popular belief, sometimes imaginary, that has no basis in reality but serves to perpetuate an opinion or world view.  Stage 1 pressure injuries are one of the common myths ingrained into our wound care lexicon.  According to NPIAP criteria, Stage 1 manifests no impairment of skin integrity, with vague and nonspecific criteria that renders its inclusion in the staging system unwarranted and misleading.   The designation of “Stage 1 Pressure Injury” should be eliminated from the st...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - May 28, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores decubiti decubitus ulcer Healthcare Quality Jeff Levine MD Jeffrey M Levine MD pressure sore pressure sores pressure ulce Source Type: blogs

Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Sufficient Physical Activity Correlates With a Halving of the Risk of Influenza Mortality
Analysis of a large epidemiological database here shows that sufficient exercise correlates with a halving of the risk of mortality due to influenza. Like many other studies, it also shows that too much exercise may be harmful, actually increasing the risk of mortality. While correlation does not imply causation, there is plenty of evidence for physical fitness and physical activity to reduce impacts of aging related to immune function. Alternative explanations revolve around the tendency of more robust individuals to conduct more exercise, while also tending to be more resilient independently of the effects of exercise. ...
Source: Fight Aging! - May 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Automated Computer Assistant for Kidney Transplant Rejection Diagnostics: Interview with Study Authors
A recent study in Nature Medicine, entitled “An automated histological classification system for precision diagnostics of kidney allografts,” has showcased the efforts of a group of researchers who have developed an automated system that can diagnose kidney transplant rejection. A variety of disparate factors can affect the chances that a transplant will be rejected. At present, clinicians have to manually consider these complex data when making decisions about transplant patients, which can lead to a high level of misdiagnosis and patient morbidity. This new system incorporates an algorithm that can synthesize t...
Source: Medgadget - May 23, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Surgery Urology INSERM kidney transplant univ_paris_cite Source Type: blogs

The Power of Connection: Why Building Relationships Is the Key to Personal and Professional Success
Establishing deep meaningful genuine relationships with others is a vital aspect of personal and professional success. Numerous studies have found that social connections are essential for our overall well-being, both physical and mental. Despite this, people often tend to overlook its importance in their lives. There’s plenty of reasons behind it. Firstly, the hectic nature of modern-day life may involve long working hours and various other responsibilities. Consequently, people fail to allocate adequate time to nurture their relationships with others.  Secondly, we’ve got spoiled by the simplicity of conne...
Source: PickTheBrain | Motivation and Self Improvement - May 8, 2023 Category: Consumer Health News Authors: Ilya Rouss Tags: career communication confidence creativity featured internet culture philosophy productivity tips self-improvement success connection Source Type: blogs

It ’s time to replace the 0 to 10 pain intensity scale with a better measure
Adapted from The Right to Pain Relief and Other Deep Roots of the Opioid Epidemic. Published by Oxford University Press in January 2023. The 0-to-10 pain intensity scale that has become a familiar feature of clinical care had its origin in experimental psychophysics studies that investigated the relationship between noxious stimulus intensity and pain experience. Read more… It’s time to replace the 0 to 10 pain intensity scale with a better measure originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 7, 2023 Category: General Medicine Authors: Tags: Conditions Pain Management Source Type: blogs

Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases. Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/ Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

On the Optimization of Exercise for Long Term Health and Longevity
How much optimization of exercise is a reasonable goal, given what is presently known? Today's open access paper makes the fair point that our hunter-gatherer evolution matches us to a certain strategy, meaning a lot of moderate exercise leavened with a smaller amount of intermittent vigorous exercise. Epidemiological evidence supports the merits of a lot of moderate exercise, while suggesting that a lot of vigorous exercise doesn't add that much to the benefits, and it is actually possible to exercise too much. The dose-response curve for exercise is one in which small amounts of effort are a great improvement over...
Source: Fight Aging! - May 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions. Plasma Transfer Lowers Epigenetic Age and Mortality in Rats https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/ Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Quantifying the Effects of Exercise on a Transcriptomic Aging Clock
The first epigenetic clocks used to assess biological age were, oddly, insensitive to the state of physical fitness. This is not an intuitive outcome, given that we know lifestyle choices relating to fitness appear have measurable effects on human life expectancy in epidemiological studies. This is one of a number of hints that suggest that most clocks are incomplete, that they only reflect some fraction of the many factors affecting health and mortality. Researchers here instead use a transcriptomic clock to assess the effects of a high intensity exercise program, and do see an effect that looks more reasonable when compa...
Source: Fight Aging! - April 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Nutrition: Major Government Fail?
Chris EdwardsAmericans are getting used to failures by government experts. Government economists have a  dismal forecasting record. Government actions and advice during the pandemic were often misguided. And dozens of former government intelligence experts got the Hunter Biden laptop storywrong.A less recognized but also important failure may be in nutrition. Federal experts appear to have issued faulty advice for decades, even as American obesityexploded from 15 percent in the 1970s to 42 percent today. Federal guidance on nutrition has a  large influence on health practice across society. Some researchers argue that Am...
Source: Cato-at-liberty - April 26, 2023 Category: American Health Authors: Chris Edwards Source Type: blogs

DC Area Startup HSR.health Receives Second Patent For Solution to Prevent Pregnancy-Related Death, Amongst Most Recent Round of Funding
HSR.health’s GeoMD Platform curates health, social, and environmental data to provide a consistent view of the current and future health situation on a global, national, and regional scale HSR.health, a leading provide of health-related geospatial data analytics, announced today that they have received the next phase of funding to support continued development of their GeoMD Platform. This GIS (Geographic Information System) solution is provided to health systems, the emergency response community, and global public health leaders to streamline and improve decision-making. This continued funding comes at the onset of thei...
Source: EMR and HIPAA - April 19, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Ajay K Gupta Disasters Pilot 2023 Federal Geographic Data Committee FGDC Geographic information system GeoMD gis Health Equity Health IT Funding Health IT Fundings Health IT Investment HSR.health Source Type: blogs

Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context. Glycine Supplementation as a Methionine Restriction Mimetic https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/ Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs