Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Maybe giving too much credit
Health reporter Julie Rovner is perplexed thatRepublicans, who she maintains were once big supporters of public health, now seem to want to kill us all. Her examples of former Republican championship for public health are pretty narrow and a bit dubious. Funding for the NIH is mostly about biomedical research, not public health; and GW Bush ' s President ' s Emergency Plan for AIDS Relief, while certainly a good thing, was focused on Africa and probably as much about international relations as humanitarianism. But it ' s certainly true that the party has turned its back on these programs: The GOP-led House this y...
Source: Stayin' Alive - December 15, 2023 Category: American Health Source Type: blogs
Klotho Levels Decline with Age, But Are Unaffected by Physical Fitness at a Given Age
Klotho is a longevity-associated gene. Klotho functions within the cell, but a portion of the full protein is also released into the bloodstream. In humans, higher levels of circulating klotho correlate with lower incidence of age-related disease and mortality. In mice, interventions such as gene therapies that increase klotho levels have been shown to extend life, while reducing klotho levels shortens life. Klotho is thought to act within the kidney, where it is protective, slowing age-related decline of kidney function. Increased klotho levels produce cognitive improvement in mice and non-human primates, however, and hig...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Thoughts on Air Pollution and Accelerated Aging
A number of large epidemiological studies demonstrate that particulate air pollution correlates with mortality and incidence of age-related disease, likely via mechanisms involving increased inflammation resulting from the interaction of particulates with lung tissue. While socioeconomic status interacts with both exposure to air pollution and life expectancy, it is nonetheless possible to disentangle these effects in some population studies. While the long-term trend is towards reduced air pollution, it seems likely that chronic inflammation will be controlled and its effects on tissues reversed via novel therapeutics on ...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
America ’ s pain management nightmare: How the DEA shaped the opioid epidemic
First, it’s essential to understand that your prosecution doesn’t define you as a person. Most likely, the DEA never bothered to speak with you before deciding to arrest and prosecute you. Even if they did, the decision to prosecute you had been made long before any conversation took place. Your prosecution is the result of
Read more…
America’s pain management nightmare: How the DEA shaped the opioid epidemic originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 10, 2023 Category: General Medicine Authors: L. Joseph Parker, MD Tags: Physician Pain Management Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in Pulmonary Fibrosis
The first small human clinical trial of the senolytic therapy of dasatinib and quercetin targeted idiopathic pulmonary fibrosis, showing some benefit to patients. Later trials for kidney disease demonstrated that this treatment does remove a fraction of lingering senescent cells in human tissues in much the same way as it does in mice. Senescent cells accumulate with age in tissues throughout the body, the burden of these cells resulting from a growing gap between pace of creation and pace of clearance by the immune system. Researchers are coming to see a prominent role for senescent cells in all fibrotic conditions, in wh...
Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Study doesn ’t find evidence to link internet access with poorer psychological well-being and mental health
Is the internet bad for mental health? What the latest study really means. (Mashable):
… Enter a study published Tuesday by researchers in the journal Clinical Psychological Science, which tried but did not succeed in finding a compelling link between internet access and poor mental health and well-being.
Business Insider, for example, declared that the study found no link between social media use and “mental health harm.” Except that’s not what the researchers evaluated.
Instead, they contrasted internet access in the form of yearly per capita internet and mobile-broadband subscriptions and various measures of wel...
Source: SharpBrains - December 7, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation Internet internet age Internet-technology neuroscience psychological psychological well-being Source Type: blogs
Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment.
In today's open access paper, the authors make the interesting point ...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why is the National Academies Appointing Alcohol-Industry Funded Researchers to Serve on Panel to Review the Health Effects of Alcohol?
In conclusion, there is no doubt that Dr. Mukamal should be removed from the National Academies panel in order to preserve the integrity of both the panel and of the National Academies itself.Although Dr. Rimm was not involved in the solicitation of funding, he didserve as a principal investigator of the MACH trial. Thus, he has been funded by the alcohol industry and this conflict of interest should disqualify him from participating in, much less chairing the panel. Dr. Rimmshould be removed from the National Academies panel in order to
preserve the integrity of both the panel and of the National Academies
itself.T...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - November 30, 2023 Category: Addiction Source Type: blogs
Intestinal Inflammation Increases with Age, and is Greater Still in Patients with Alzheimer's Disease
16s rRNA sequencing allows the microbial populations resident in the gut to be catalogued in detail: which species are present, and relative numbers by species. In the years since this assay became cheap, reliable, and readily available, researchers have built increasingly large human gut microbiome databases from samples obtained over the course of epidemiological studies. The research community has found that the gut microbiome exhibits characteristic differences in older people, marked by a growth in populations of inflammatory microbes and a loss of those species that produce beneficial metabolites. Further, some age-r...
Source: Fight Aging! - November 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Associations Between Gut Microbiome and Risk of Age-Related Neurodegenerative Disease
It is becoming clear that there are correlations between the composition of the gut microbiome and risk of suffering neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. The gut microbiome changes with age, the populations of inflammatory microbes growing in size, while microbes that create beneficial metabolites are diminished in number. Even only considering the effects of additional chronic inflammation in later life, it is clear that a more inflammatory gut microbiome is harmful. There may be other ways in which gut-resident microbes can contribute to neurodegenerative conditions, however. ...
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Learning from Laron Syndrome
The longest lived mice are still those engineered to lack functional growth hormone or growth hormone receptor. That record was established more than 20 years ago, and remains in place even as an energetic research and development community focused on treating aging as a medical condition has come into being. In part this is the case because research has largely focused on approaches known to produce lesser effects on aging in mice, such as the discovery of small molecules that mimic portions of the calorie restriction response. In part it is because the pace of development in the life sciences is ever slower than we would...
Source: Fight Aging! - November 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
