A Genome-Wide Genetic Association Study of Sleep Duration and Longevity
In this study, we firstly studied the genome-wide genetic association between four sleep behaviors (short sleep duration, long sleep duration, insomnia, and sleep chronotype) and lifespan using GWAS summary statistics, and both sleep duration time and insomnia were negatively correlated with lifespan. Then, two-sample Mendelian randomization (MR) and multivariable MR analyses were applied to explore the causal effects between sleep behaviors and lifespan.
We found that genetically predicted short sleep duration was causally and negatively associated with lifespan in univariable and multivariable MR analyses, and thi...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Are AI Clinical Protocols A Dobb-ist Trojan Horse?
By MIKE MAGEE
For most loyalist Americans at the turn of the 19th century, Justice John Marshall Harlan’s decision in Jacobson v. Massachusetts (1905). was a “slam dunk.” In it, he elected to force a reluctant Methodist minister in Massachusetts to undergo Smallpox vaccination during a regional epidemic or pay a fine.
Justice Harlan wrote at the time: “Real liberty for all could not exist under the operation of a principle which recognizes the right of each individual person to use his own, whether in respect of his person or his property, regardless of the injury that may be done to others.”
What could ...
Source: The Health Care Blog - March 1, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Abortion AI Dobbs Forced Sterilization Mike Magee racial bias SCOTUS Vaccination Source Type: blogs
Sham peer review epidemic: A doctor ’ s career destroyed
An excerpt from The Medical Matrix: One Physician’s Story Maneuvering the Minefields of Medicine. It was a routine Monday morning in the middle of May 2011. I had custody of my boys that day, so I dropped them off at school and headed to work. As soon as I got to work I received a
Read more…
Sham peer review epidemic: A doctor’s career destroyed originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 28, 2024 Category: General Medicine Authors: Aysun Alagoz, MD Tags: Physician Hospital-Based Medicine Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why ICDs are less effective in Non Ischemic DCM ?
We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.
SCD is the leading cause of mortality in heart failure. Tackling SCD was in God’s domain, until the brilliance of Dr. Michel Mirowski shrunk the defibrillator and implanted it under the chest in 1980. (Dr. MM’s s a unique and inspiring story, from Poland a...
Source: Dr.S.Venkatesan MD - February 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized crt device crt-p vs crt-d danish trial ischemic dcm madit trial non ischemic dcm Source Type: blogs
The inflection point
Okay, pretty correct answers from our two commenters on the previous post. Not just chlorination, but clean water generally, i.e. sewage treatment and separating sewage from drinking water sources. Also pasteurization of milk was very important. But the story is a bit more complicated. Pre-industrial people were mostly rural, obviously drank their milk fresh and didn ' t have a lot to fear from waterborne diseases since their population was sparse. Obviously they did suffer greatly from other plagues -- the Black Death killed something like half the population of Europe in the mid-14th Century, and plague recurred in lesse...
Source: Stayin' Alive - February 20, 2024 Category: American Health Source Type: blogs
To What Degree is Alzheimer's Disease a Modern Phenomenon?
Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer's disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer's disease is a creation of modernity, some combination of a longer life expectancy for a greater fraction of the population coupled with increased calorie intake and less active lives. Yet unlike type 2 diabetes, risk of Alzheimer's risk doesn't correlate well with the usual suspect lifestyle choices that raise the risk of age-related disease and lower life expectancy.
This line of thinking has l...
Source: Fight Aging! - February 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why the Low Weight Group Exhibits Worse Outcomes in Some Epidemiological Studies
In this study, we first explored the association between WC, WHtR, and WWI change patterns and multimorbidity. WC and WHtR are considered to be important anthropometric indicators of abdominal obesity. Previous studies have suggested that WC and WHtR can reflect body fat percentage accurately and play an important role in predicting some chronic diseases, such as cardiovascular disease and metabolic syndrome. The pathway may explain that abdominal obesity significantly increased plasma triglycerides, low density lipoproteins, and very low density lipoproteins, which have been shown to increase the risk of adverse outcomes ...
Source: Fight Aging! - February 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Purdue Pharma, The Sackler Family, and The U.S. Opioid Epidemic
Lawrence J. Trautman (Prairie View A&M University), Larry D. Foster, II (Prairie View A&M University), Purdue Pharma, The Sackler Family, and The U.S. Opioid Epidemic (2023): During recent years, the continued outbreak of addiction in the United States has reached... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - February 13, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
The bias of reality
Stephen Colbert -- or rather " Stephen Colbert, " in his former character -- famously said that " Reality has a well-known liberal bias. " And so conservatives must deny reality, which as in the case of anthropogenic climate change means denying scientific findings, and the very integrity and authority of science. But that doesn ' t usually work very well with the courts --viz. the jury award of $1 million to climate scientist Michael Mann -- so they also result to scientific fraud.You may recall that U.S. District Judge Matthew Kacsmaryk ruled to suspend FDA approval of the abortion medication mifepristone,relying largely...
Source: Stayin' Alive - February 9, 2024 Category: American Health Source Type: blogs
Systematic review finds more clinical harm than benefits in Alzheimer ’s “treatments” lecanemab, aducanumab, and donanemab
CONCLUSIONS: Although monoclonal antibodies targeting amyloid provide small benefits on cognitive and functional scales in patients with Alzheimer dementia, these improvements are far below the MCID for each outcome and are accompanied by clinically meaningful harms.
The Study in Context:
Should doctors prescribe lecanemab (Leqembi) to women? The answer, given available evidence, is probably No
First, do no harm? Six reasons to approach anti-amyloid drug Aduhelm cautiously, if at all
Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors
The post Systematic review fi...
Source: SharpBrains - February 9, 2024 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health aducanumab Alzheimer's drug Alzheimers-treatment brain bleeds brain swelling cognition dementia donanemab FDA lecanemab Leqembi Medicare Mini-Mental State test minimal clinically important difference mono Source Type: blogs
The opioid addiction epidemic and its impact on health care costs
The opioid addiction crisis has escalated into a formidable challenge within the U.S. health care system, causing widespread devastation. The opioid epidemic has not only devastated communities and individual lives but has also inflicted a substantial economic toll on the health care system. The opioid epidemic has led to a surge in health care costs,
Read more…
The opioid addiction epidemic and its impact on health care costs originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 5, 2024 Category: General Medicine Authors: Brocha Kagan, PA-C Tags: Conditions Emergency Medicine Pain Management Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
