Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation
Int Immunopharmacol. 2024 Apr 1;132:111942. doi: 10.1016/j.intimp.2024.111942. Online ahead of print.ABSTRACTEndometriosis (EM) is a gynecological inflammatory disease often accompanied by stress, chronic pelvic pain (CPP), anxiety, and depression, leading to a diminished quality of life. This review aims to discuss the relationship between systemic and local inflammatory responses in the central nervous system (CNS), focusing on glial dysfunctions (astrocytes and microglia) as in critical brain regions involved in emotion, cognition, pain processing, anxiety, and depression. The review presents that EM is connected to inc...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Tahmineh Mokhtari Elnaz Irandoost Fatemeh Sheikhbahaei Source Type: research
Atypical myocytes: A quirky impersonator in surgical scar endometriosis!
Indian J Pathol Microbiol. 2024 Mar 25. doi: 10.4103/ijpm.ijpm_563_23. Online ahead of print.NO ABSTRACTPMID:38563708 | DOI:10.4103/ijpm.ijpm_563_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Archana Shetty Vijaya Mysorekar Source Type: research
Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1
CONCLUSIONS: IGF2BP1 exhibits potential beneficial properties in the management of EMs by interacting with PTBP1, thereby highlighting IGF2BP1 as a promising therapeutic target for EMs.PMID:38563050 | DOI:10.5603/fhc.98213 (Source: Folia Histochemica et Cytobiologica)
Source: Folia Histochemica et Cytobiologica - April 2, 2024 Category: Cytology Authors: Yanlin Su Wencai Tian Li Cheng Ling Yin Xiaoxia He Xin Wei Source Type: research
Assessment of quality of life, psychological aspects, and sexual function of women with endometriosis according to pain and infertility: a cross sectional study
ConclusionPain symptoms worsen anxiety, depression, and quality of life of women with endometriosis and when associated with infertility, greater impairment of psychological aspects may occur. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 2, 2024 Category: OBGYN Source Type: research
Mast Cells and Vascular Endothelial Growth Factor Contribute to Pelvic Tactile Allodynia in a Non-invasive Mouse Model of Endometriosis
Endometriosis (EM) impacts ~4 million women in the US. EM lesions are infiltrated with mast cells (MCs) and have elevated vascular endothelial growth factor (VEGF). To test the hypothesis that MC and VEGF drive endometriosis-associated pelvic pain, we assessed therapeutic agents on pelvic tactile allodynia in a mouse model of EM. C57BL/6J donor mice (6-weeks old) received a subcutaneous injection of estradiol benzoate (10 µg), and 4 days later, each uterine horn was excised and placed in Hank’s Balanced Salt Solution (HBSS) and minced. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Pranav Prasoon, Sarvesh Acharya, Bradley K. Taylor, Kenny M. Roman Source Type: research
128. Understanding TikTok as a Source of Medical Information about Endometriosis
This study aims to systematically assess the content on TikTok pertaining to endometriosis. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Eugenie Lehembre-Shiah, Harrison Kronfeld, Jordan Eisenberg, Swetha Naroji, Amos Grunebaum Source Type: research
122. Surgical Management and Postoperative Complications in Adolescents with Pathology Proven Endometriosis
Adolescents with significant dysmenorrhea may have endometriosis. When medical management is unsuccessful or unsatisfactory, some choose laparoscopy alone or with other procedures to potentially diagnose and/or treat endometriosis. ACOG calls for a shared medical decision making regarding diagnostic laparoscopy. However, risks associated with laparoscopy specific to this patient population are not well described. This multi-institutional study sought to characterize intraoperative management and complications for adolescents with pathology confirmed endometriosis. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Katherine Bergus, Paige Hertweck, Holly Hoefgen, Anne Horne, Ashli Lawson, Seema Menon, Kathleen O'Brien, Shashwati Pradhan, Geri Hewitt, MWPAG Source Type: research
111. Racial and ethnic inequities in rates of diagnostic laparoscopy for evaluation of pelvic pain in adolescent patients
This study aimed to identify inequities in rates of diagnostic laparoscopy among adolescents presenting with dysmenorrhea or CPP according to race, ethnicity, and socioeconomic status (SES). (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Lauren Capra, Kathleen O'Brien, Susan Woolford, Niko Kaciroti, Harlan McCaffery, Cheyney Dobson, Erin Isaacson, Sarah Block, Monica Rosen Source Type: research
103. Plasma Anti-M üllerian Hormone Concentrations in Adolescents and Young Adults with Endometriosis
We examined AMH levels in adolescents and young adults (AYA; (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Emma Singleton, Allison Vitonis, Ashley Laliberte, Amy Shafrir, Stacey Missmer, Kathryn Terry, Amy DiVasta Source Type: research
98. Patient characteristics associated with pain remediation one year after endometriosis-related surgery: EndoQUEST
Not all patients with endometriosis will experience pain remediation after surgical treatment, but few predictors of treatment refractory chronic pain are known – especially among adolescents. We therefore assessed behavioral and symptom characteristics prior to surgery as predictors of pain symptoms one year after surgery. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Amy Shafrir, Allison Vitonis, Amy DiVasta, Emma Draisin, Marc Laufer, Naoko Sasamoto, Christine Sieberg, Kathryn Terry, Stacey Missmer Source Type: research
97. Pain Interference in Adolescents and Adults with Chronic Pelvic Pain Due to Endometriosis
This study aims to examine how PI experiences may differ between adolescent and adult patients with CPP due to endometriosis. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Emma Draisin, Catherine Stamoulis, Jenny Gallagher, Sinah Esther Kim, Marc Laufer, Amy DiVasta Source Type: research
34. Correlates of Endometriosis Diagnosis from Diagnostic Laparoscopy for Pelvic Pain in Transgender-Non Binary Patients
Endometriosis is estimated to affect 49-75% of adolescents with chronic pain who undergo laparoscopy. The prevalence of endometriosis in transgender-nonbinary (TGNB) adolescent and young adults (AYA) is estimated at 25% but data is limited. Interaction between gender dysphoria and pelvic pain have been poorly characterized. We aimed to describe the characteristics and rate of endometriosis in TGNB AYA patients who underwent diagnostic laparoscopy for pelvic pain at a single institution. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Vidhya Krishnan, Geri Hewitt, Vidya Mullangi, Kate McCracken, Yueyang Fei, Chelsea Kebodeaux Source Type: research
21. Characteristics and Preoperative Management of Pediatric and Adolescent Patients with Pathology Proven Endometriosis
Endometriosis is a significant cause of dysmenorrhea and chronic pelvic pain in adolescents. Treatment includes both medical and surgical interventions. Patients with pathology proven endometriosis have primarily been examined through single-institution case series and preoperative management has been sparsely characterized. This multi-institutional study sought to characterize demographics and preoperative management of patients who underwent laparoscopy and had pathology confirmed endometriosis. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Katherine Bergus, Paige Hertweck, Holly Hoefgen, Anne Horne, Ashli Lawson, Seema Menon, Shashwati Pradhan, Yolanda Smith, Geri Hewitt, on behalf of MWPAG Source Type: research
