Global trends and differences in the burden of alcohol use disorders attributable to childhood sexual abuse by sex, age, and socio-demographic index: Findings from the Global Burden of Disease Study 2019
CONCLUSIONS: Substantial geographical differences were observed in the burden of AUD attributable to CSA. The level of CSA exposure was inconsistent with the related burden of AUD in different regions according to the sociodemographic index. The burden of disease increased in the elderly population and in females in high sociodemographic index regions.PMID:38696952 | DOI:10.1016/j.chiabu.2024.106818 (Source: Child Abuse and Neglect)
Source: Child Abuse and Neglect - May 2, 2024 Category: Child Development Authors: Yifan Chen Yunxi Zhong Meiqi Wang Xiaoying Su Qixiu Li Jie Wang Long Sun Source Type: research
The burden of disease due to dietary exposure to acrylamide in Italy: a risk assessment-based approach
Food Chem Toxicol. 2024 Apr 30:114699. doi: 10.1016/j.fct.2024.114699. Online ahead of print.ABSTRACTThe aim of this study was to assess Italian consumers' risk of cancer and burden of disease due to dietary exposure to acrylamide. Our model considered six age groups such as infants, toddlers, other children, adolescents, adults, and the elderly, and the consumption of 31 food items. Using a risk-assessment-based approach, we first characterized the risk of neoplastic effects using the margin of exposure method. Then the risk of kidney, endometrial, breast, ovarian cancer, and total cancer was estimated using adjusted canc...
Source: Food and Chemical Toxicology - May 2, 2024 Category: Food Science Authors: Octavian Augustin Mihalache Chiara Dall'Asta Source Type: research
Emerging technology has a brilliant future: the CRISPR-Cas system for senescence, inflammation, and cartilage repair in osteoarthritis
Cell Mol Biol Lett. 2024 May 2;29(1):64. doi: 10.1186/s11658-024-00581-x.ABSTRACTOsteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations, and subsequent cartilage defects, OA eventually leads to a series of adverse outcomes such as pain and disability. CRISPR-Cas-related technology has been proposed and explored as a gene therapy, offering potential gene-editing tools that are in the spotlight. Considering the genetic and multi...
Source: Cellular and Molecular Biology Letters - May 2, 2024 Category: Biochemistry Authors: Shicheng Jia Rongji Liang Jiayou Chen Shuai Liao Jianjing Lin Wei Li Source Type: research
Cervical Disk Replacement Versus Anterior Cervical Diskectomy and Fusion: Effect of Procedural Variant on Patients With a Prolonged Preoperative Duration of Symptoms From Disk Herniation
CONCLUSION: Patients with prolonged PSD due to cervical DH demonstrated notable improvements in physical function, disability, pain, and mental health regardless of fusion versus arthroplasty techniques. Accounting for demographic variations, patients undergoing CDA demonstrated a greater magnitude of improvement and superior scores in physical function at the first postoperative follow-up. Rates of clinically tangible improvements in PROMs did not markedly vary by surgical procedure. Patients undergoing CDA may perceive greater early improvements to physical function compared with patients undergoing ACDF for prolonged PS...
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 2, 2024 Category: Orthopaedics Authors: Timothy J Hartman James W Nie Ishan Khosla Omolabake O Oyetayo Keith R MacGregor Eileen Zheng Fatima N Anwar Andrea M Roca Alexandra C Loya Srinath S Medakkar Vincent P Federico Dustin H Massel Arash J Sayari Gregory D Lopez Kern Singh Source Type: research
Emerging technology has a brilliant future: the CRISPR-Cas system for senescence, inflammation, and cartilage repair in osteoarthritis
Cell Mol Biol Lett. 2024 May 2;29(1):64. doi: 10.1186/s11658-024-00581-x.ABSTRACTOsteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations, and subsequent cartilage defects, OA eventually leads to a series of adverse outcomes such as pain and disability. CRISPR-Cas-related technology has been proposed and explored as a gene therapy, offering potential gene-editing tools that are in the spotlight. Considering the genetic and multi...
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Shicheng Jia Rongji Liang Jiayou Chen Shuai Liao Jianjing Lin Wei Li Source Type: research
The WALLET Study: Financial Decision Making and Key Financial Behaviors Associated with Excess Spending
CONCLUSIONS: The multidimensional nature of financial capacity assessment has long been known. The WALLET study data is unique, however, in that it demonstrates the links between excess spending with decision-making, early memory loss, and a set of specific financial behaviors.CLINICAL IMPLICATIONS: Real-world assessments of financial management and financial decision-making yield important information about how older adults are managing money and making key financial decisions. Checking account reviews can be used to determine excess spending.PMID:38695303 | DOI:10.1080/07317115.2024.2348049 (Source: Clinical Gerontologist)
Source: Clinical Gerontologist - May 2, 2024 Category: Geriatrics Authors: Peter A Lichtenberg Vanessa Rorai Emily V Flores Wassim Tarraf Source Type: research
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral arterial disease
CONCLUSIONS: There is very uncertain evidence that additional exercise therapy after successful lower limb revascularisation may improve absolute maximal walking distance at the end of follow-up compared to standard care. Evidence is also very uncertain about the effects of exercise on pain-free walking distance, six-minute walk test distance, quality of life, ankle-brachial index, mortality, and reintervention rates. Although it is not possible to confirm the effectiveness of supervised exercise compared to standard care for all outcomes, studies did not report any harm to participants from this intervention after lower l...
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Gabriel Cucato Paulo Pl Longano Daniel Perren Raphael M Ritti-Dias John M Saxton Source Type: research
Non-invasive high-frequency ventilation in newborn infants with respiratory distress
CONCLUSIONS: For initial RS, we are very uncertain if using nHFV compared to invasive respiratory therapy affects clinical outcomes. However, nHFV may reduce intubation when compared to nCPAP. For planned extubation, nHFV may reduce the risk of reintubation compared to nCPAP and nIPPV. nHFV may reduce the risk of CLD when compared to nCPAP. Following initial non-invasive respiratory support failure, nHFV when compared to nIPPV may result in little to no difference in intubation. Large trials, particularly in high-income settings, are needed to determine the role of nHFV in initial RS and following the failure of other non-...
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Mohamed E Abdel-Latif Olive Tan Michelle Fiander David A Osborn Source Type: research
Can boxing relieve symptoms of Parkinson's disease and improve quality of life? A qualitative study of the experiences of participants attending the Danish Parkinson boxing concept
CONCLUSIONS: The experienced impact of participating in PB relates to physical relief of symptoms and improved functioning in everyday life, as well as a mental lift, energy, and joy during and after training sessions. Participants described being motivated to attend PB and to continue their training practice. Thus, PB entails experiences of relief of symptoms and presumably improved quality of life for the participants.PMID:38695285 | DOI:10.1080/09638288.2024.2346238 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - May 2, 2024 Category: Rehabilitation Authors: Nafisa Mohamed Abdi Yusuf Pernille Bekke Stine Kj ær Wehner Source Type: research
Bardet-Biedl syndrome with unique manifestations of congenital giant nevi and refractory anemia: a case report from Palestine
CONCLUSION: This case underscores BBS's rarity and complexity, featuring unique aspects like giant nevi and refractory IDA. Comprehensive management addresses renal, visual, cardiac, and neurologic aspects. Genetic counselling, prenatal testing, and preimplantation genetic diagnosis prevent transmission. Limitations include lacking local epidemiological data and prior studies in Palestine. This case contributes insights, stressing multidisciplinary management and prompting further research in underexplored populations.PMID:38694397 | PMC:PMC11060271 | DOI:10.1097/MS9.0000000000001954 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mohammad Milhem Daleen Shehadeh Yasmeen Abu Nawa Roa Arman Lara Masri Zeena Salman Mohammad Najajreh Source Type: research
Syrian child carrying multiple pathogenic variants in MBOAT7 and MT-TS1 genes: a case report on neurodevelopmental phenotypes and mitochondrial inheritance
CONCLUSION: The presence of the MBOAT7 and MT-TS1 gene variants in the same child is noteworthy. The authors must keep genetic mutations of MBOAT7 and MT-TS1 gene in mind as a differential diagnosis for intellectual disability, seizures and autistic features in children, especially in consanguineous families.PMID:38694353 | PMC:PMC11060275 | DOI:10.1097/MS9.0000000000001941 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Alyamama Kousa Reem Ahmed Pr Diana Alasmar Source Type: research
The Efficacy of Web-Based Marriage Preparation Education for Premarital Couples
This study aimed to evaluate the impact of web-based marriage preparation education provided to engaged couples before marriage on their knowledge of sexual and reproductive health, marital adjustment, sexual satisfaction, and sexual self-efficacy. The randomized controlled experimental study took place between September 2021 and November 2022 at a municipal marriage registry office in Ankara. The study enrolled 60 engaged couples embarking on their first marriage (30 couples assigned to the intervention group and 30 to the control group). The intervention group received web-based marriage preparation education, while the ...
Source: Sexuality and Disability - May 2, 2024 Category: Disability Source Type: research
Comparison of bacterial species and clinical outcomes in patients with diabetic hand infection in tropical and nontropical regions
AbstractHand infection is a rare complication in patients with diabetes. Its clinical outcomes depend on the severity of hand infection caused by bacteria, but the difference in bacterial species in the regional disparity is unknown. The purpose of this study was to explore the influence of tropical and nontropical regions on bacterial species and clinical outcomes for diabetic hand. A systematic literature review was conducted using PubMed, EMBASE, Web of Science, and Google Scholar. Moreover, the bacterial species and clinical outcomes were analyzed with respect to multicenter wound care in China (nontropical regions). B...
Source: Archives of Dermatological Research - May 2, 2024 Category: Dermatology Source Type: research
Correlation between disease activity and patient-reported health-related quality of life in rheumatoid arthritis: a cross-sectional study
Conclusions
RA can have considerable impairment on patients’ HRQoL, both in terms of physical and psychosocial functioning. Given the strong correlation between clinical activity and HRQoL scores, and the fact that HRQoL can be an important clinical supplement. The EQ-5D-5L is probably the most appropriate generic measurement instrument for measuring HRQoL in RA patients. (Source: BMJ Open)
Source: BMJ Open - May 2, 2024 Category: General Medicine Authors: Feng, J., Yu, L., Fang, Y., Zhang, X., Li, S., Dou, L. Tags: Open access, Rheumatology Source Type: research
Exploring functional abilities and competing risks among stroke patients: a longitudinal and survival analysis study at Felege Hiwot Referral Hospital, Ethiopia
Conclusion
A substantial proportion of patients who had a stroke experienced mortality and drop-out during the study period, highlighting the importance of considering competing risks in stroke research. Age, diabetes, white cell count and stroke complications were significant covariates affecting both longitudinal and survival submodels. Compared with stand-alone models, the joint competing risk modelling technique offers comprehensive insights into the disease’s transition pattern. (Source: BMJ Open)
Source: BMJ Open - May 2, 2024 Category: General Medicine Authors: Berehan, H. B., Dessie, Z. G., Tesfaw, L. M. Tags: Open access, Public health Source Type: research
