Work Disability and Return to Work After Treatment for Acute Lymphoblastic Leukemia: A Danish Nationwide Cohort Study [Letter]
(Source: Clinical Epidemiology)
Source: Clinical Epidemiology - April 24, 2024 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
It is up to healthcare professionals to talk to us in a way that we can understand: informed consent processes in people with an intellectual disability
People with an intellectual disability form a sizeable minority group. Estimates of prevalence vary, depending on criteria used, but it is thought that intellectual disability affects around 1%–2% of the world population.1 2 Intellectual disability is present when the following three criteria are met: a significantly reduced ability to understand new or complex information, or to learn and apply new skills (impaired intelligence); a reduced ability to cope independently (impaired social functioning); and beginning before adulthood, with a lasting effect on development.3 4 Health inequities People with an intellectual...
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Ding, J., Keagan-Bull, R., Tuffrey-Wijne, I. Tags: Editorials Source Type: research
Equitable and accessible informed healthcare consent process for people with intellectual disability: a systematic literature review
Conclusions
Multiple reasons contribute to poor consent practices for people with intellectual disability in current health systems. Recommendations include addressing health professionals’ attitudes and lack of education in informed consent with clinician training, the co-production of accessible information resources and further inclusive research into informed consent for people with intellectual disability.
PROSPERO registration
CRD42021290548. (Source: BMJ Quality and Safety)
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Dunn, M., Strnadova, I., Scully, J. L., Hansen, J., Loblinzk, J., Sarfaraz, S., Molnar, C., Palmer, E. E. Tags: Open access Systematic review Source Type: research
Reliability, validity, and responsiveness of the Arabic version of HIT-6 questionnaire in patients with migraine indicated for preventive therapy: A multi-center study
CONCLUSION: The Arabic version of HIT-6 is valid, reliable, and sensitive to detect clinical changes following migraine prophylactic treatment with a MIC of 4.5 points.PMID:38651363 | DOI:10.1111/head.14719 (Source: Headache)
Source: Headache - April 23, 2024 Category: Neurology Authors: Mona Hussein Amr Hassan Mona A F Nada Zeinab Mohammed Nawal F Abdel Ghaffar Hanaa Kedah Wael Fathy Rehab Magdy Source Type: research
Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients
CONCLUSION: Serum TBA is an independent risk factor for disability and poor functional outcomes after AIS or TIA, and exerts a protective effects on brain.PMID:38650617 | PMC:PMC11033300 | DOI:10.3389/fnins.2024.1388748 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Zhaobin Wang Jing Li Yingxin Xu Ye Liu Zhe Zhang Qin Xu Jinxi Lin Yong Jiang Yongjun Wang Jing Jing Anxin Wang Xia Meng Source Type: research
Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments
CONCLUSION: Subjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy.PMID:38652168 | DOI:10.1007/s00520-024-08504-4 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Masahiro Manfuku Junichiro Inoue Nobuki Yamanaka Hiroe Kanamori Kazuhiro Sumiyoshi Michihiro Osumi Source Type: research
5Z ‐7‐Oxozaenol attenuates cuprizone‐induced demyelination in mice through microglia polarization regulation
ConclusionThese findings suggest that inhibiting TAK1 may be an effective approach for treating demyelinating diseases. (Source: Brain and Behavior)
Source: Brain and Behavior - April 23, 2024 Category: Neurology Authors: Shiyu Chen,
Siyao Liu,
Yalun Huang,
Shiwen Huang,
Wanzhou Zhang,
Huifang Xie,
Lingli Lu Tags: ORIGINAL ARTICLE Source Type: research
Meeting speech, language and communication needs: a whole-systems, population-based approach
This article sets out the case for taking a population-health based approach to anticipating need and building whole systems around children in their functional contexts, whether home, early years setting, school or further education. The demand on services providing speech and lang uage therapy continues to increase year on year. Using a population-health approach to predicting areas of higher anticipated SLCN and establishing robust collaborative approaches to improving the context for children and young people vulnerable to SLCN, there is the potential to address a significa nt number needs within everyday contexts. (So...
Source: Paediatrics and Child Health - April 23, 2024 Category: Pediatrics Authors: Marie Gascoigne Tags: Symposium: special educational needs and disability Source Type: research
Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model
In this study, we examined whether elevated astrocyte purinergic signalling also impacts neuronal morphology and connectivity ofFmr1 KO cortical neurons. Here, we found that conditioned media from primaryFmr1 KO astrocytes was sufficient to enhance neurite extension and complexity of both wildtype andFmr1 KO neurons to a similar degree as UTP-mediated outgrowth. Significantly enhanced firing was also observed inFmr1 KO neuron-astrocyte co-cultures grown on microelectrode arrays but was associated with large deficits in firing synchrony. The selective P2Y2 purinergic receptor antagonist AR-C 118925XX effectively normalized ...
Source: Molecular Neurobiology - April 23, 2024 Category: Neurology Source Type: research
Outcomes after radioscapholunate arthrodesis for intra-articular malunion of distal radius fractures
ConclusionRSL arthrodesis (using locked miniplates without distal scaphoid excision) is a reliable surgical procedure to manage cases of radiocarpal OA after intra-articular malunion of distal radius fractures with good clinical and radiological outcomes.Level of evidenceLevel IV- therapeutic. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - April 23, 2024 Category: Orthopaedics Source Type: research
Co-design of an intervention to optimize mammographic screening participation in women with obesity and/or physical disabilities
This study describes development of an intervention framework targeting obesity- and disability-related barriers to improve participation. (Source: Radiography)
Source: Radiography - April 23, 2024 Category: Radiology Authors: K.A. McBride, A. O'Fee, S. Hogan, E. Stewart, C. Madeley, J. Wilkes, E. Wylie, A. White, M. Hickey, J. Stone Source Type: research
Real world data in mechanical thrombectomy: who are we losing to follow-up?
Conclusion
MOD in routine care MT registry data was not random. Increased efforts to perform clinical follow-up are needed, especially in the case of higher pre-stroke and post-stroke disability and discharge to hospital or institutional care.
Trial registration
NCT03356392. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Hahn, M., Gröschel, S., Othman, A., Brockstedt, L., Civelek, A., Brockmann, M. A., Gröschel, K., Uphaus, T., On behalf of German Stroke Registry Endovascular Treatment-Steering Committee, Röther, Eckert, Braun, Hamann, Siebert, Nol Tags: Open access, Ischemic stroke Source Type: research
Which is Better in Predicting CT Scores in Patients with Chronic Rhinosinusitis after Medical treatment-Baseline Rhinosinusitis Disability Index (RSDI) or Endoscopic Score?
ConclusionStatistically significant (p < 0.001) association was found between baseline Lund-Kennedy endoscopic scores and Mackay-Lund CT scores post medical treatment. No significant association was found between RSDI scores and Mackay-Lund CT scores. ROC analysis indicated that Lund- Kennedy endoscopy score is a more accurate tool than RSDI score to predict a Mackay-Lund CT scores after medical treatment. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Do the management and functional outcomes of the surgically treated spinal fractures change in suicidal jumpers?
ConclusionPsychiatric disorders are more common in patients in the suicidal jumpers. The presence of underlying psychiatric problems adversely affects the postoperative functional outcomes of patients with surgically treated spinal fractures. A multidisciplinary approach together with raising awareness in this way can improve the clinical outcomes after orthopedic treatment, even if there is physical disability. (Source: European Spine Journal)
Source: European Spine Journal - April 23, 2024 Category: Orthopaedics Source Type: research
Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments
ConclusionSubjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 23, 2024 Category: Cancer & Oncology Source Type: research
