Community screening for dementia among older adults in China: a machine learning-based strategy
This study combined specific questions fr... (Source: BMC Public Health)
Source: BMC Public Health - May 1, 2024 Category: Consumer Health News Authors: Yan Zhang, Jian Xu, Chi Zhang, Xu Zhang, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yijin Zheng and Zhiguang Zhao Tags: Research Source Type: research
Anti-TNF (adalimumab) injection for the treatment of pain-predominant early-stage frozen shoulder: the Anti-Freaze-Feasibility randomised controlled trial
Conclusion
This study demonstrated that current NHS musculoskeletal physiotherapy settings yielded only small numbers of participants, too few to make a trial viable. This was because many patients had passed the early stage of frozen shoulder or had already formulated a preference for treatment.
Trial registration number
ISRCTN 27075727, EudraCT 2021-03509-23, ClinicalTrials.gov NCT05299242 (REC 21/NE/0214). (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Hopewell, S., Srikesavan, C., Evans, A., Er, F., Rangan, A., Preece, J., Francis, A., Massa, M. S., Feldmann, M., Lamb, S., Nanchahal, J. Tags: Open access, Rehabilitation medicine Source Type: research
Role of virtual reality in examining the effect of fear of falling (FOF) on postural stability in individuals without and with Parkinsons disease in Egypt: a mixed-methods feasibility study protocol
This study will assess a range of FOF-related responses, including cognitive factors, neuromuscular response and postural stability.
Methods and analysis
This feasibility study will consist of four phases: the first two phases will include people without PD, while the other two will include people diagnosed with PD. Participants will be assessed for direct and indirect responses to real life, as well as virtual environment walking scenarios that may induce FOF. Data from questionnaires, different neurophysiological assessments, movement and gait parameters, alongside evaluations of usability and acceptability, will be col...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Gomaa, Y. S., Awad, M. I., Emara, T., Elbokl, A., Al-Yahya, E., ElMeligie, M. M. Tags: Open access, Rehabilitation medicine Source Type: research
Cost analysis for initiating an integrated package of essential non-communicable disease interventions (PEN-Plus) in Kondoa District Hospital, Tanzania: a time-driven activity-based costing (TDABC) study protocol
This study aims to estimate the cost of initiating PEN-Plus for rheumatic heart disease, sickle cell disease and type 1 diabetes at Kondoa district hospital in Tanzania.
Methods and analysis
We will employ time-driven activity-based costing (TDABC) to quantify the capacity cost rates (CCR), and capital and recurrent costs associated with the implementation of PEN-Plus. Data on resource consumption will be collected through direct observations and interviews with nurses, the medical officer in charge and the heads of laboratory and pharmacy units/departments. Data on contact times for targeted NCDs will be collected by obs...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Ndumwa, H. P., Mori, A. T., Ruhago, G. M., Willilo, R., McBain, R., Boudreaux, C., Wroe, E., Adler, A. J., Bukhman, G., Mayige, M. T., Kaarboe, O. Tags: Open access, Health economics Source Type: research
Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community
Introduction
Although short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effects of parenteral ketamine, high relapse rates following ketamine dosing and the uncertain role of psychotherapy. This randomised controlled trial (RCT) seeks to establish the feasibility of evaluating repeated oral doses of ketamine and behavioural activation therapy (BAT), compared with ketamine treatment alone, for TR-MDD. We also aim to compare relapse rates between treatment arms to ...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Beaglehole, B., Porter, R., Douglas, K., Lacey, C. J., de Bie, A., Jordan, J., Mentzel, C., Thwaites, B., Manuel, J., Murray, G., Frampton, C., Glue, P. Tags: Open access, Mental health Source Type: research
Body awareness disturbances in patients with low back pain: a systematic review
ConclusionsBody perception disturbances in LBP seem to be a promising path that needs to be further explored, with the ultimate goal of developing treatment contents targeting body awareness as a more comprehensive and valid evaluation and therapeutic method.Trial registrationThe registration number was CRD42021235934. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - May 1, 2024 Category: Neurology Source Type: research
Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial
ConclusionNEC versus placebo in a multisite randomized trial is feasible and well-tolerated. Additional studies with larger sample size are needed to further evaluate the efficacy and safety of NEC in treatment of AIIA.ClinicalTrials.gov Identifier: NCT03865992, first posted March 7, 2019. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 1, 2024 Category: Cancer & Oncology Source Type: research
Improving Kidney Transplant Rates in Obese CKD Patients by Sleeve Gastrectomy
Obesity is a central obstacle to health and wellness in people with chronic kidney disease (CKD). It is linked to progression of CKD, a greater burden of disease and disability, and reduced access to kidney transplant.1-3 Moreover, obesity is a common condition in CKD, being seen in nearly 50% of individuals with CKD stages 3 and 4.4 As a highly prevalent and major risk factor for adverse outcomes, obesity has been receiving increasing attention from the nephrology community as an urgent problem that needs addressing. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 1, 2024 Category: Internal Medicine Authors: Allon N. Friedman Tags: Editorial Source Type: research
Suicide Attempt in a Case of Dopamine Agonist Withdrawal Syndrome in Parkinson's Disease
Background: Dopamine agonist withdrawal syndrome (DAWS) results from the reduction or suspension of dopamine agonist medications, it includes mainly psychiatric symptoms, including suicidal behaviors. In patients with Parkinson's disease (PD), the impact of DAWS can be significant in terms of distress and disability; however, we must take this syndrome into account as a threatening condition because suicidal behaviors could develop in the context of DAWS. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Espindola, N. Gonzalez Rojas, G. DaPrat, M. Cesarini, J.L. Etcheverry, E.M. Gatto Source Type: research
Risk of developing Parkinson's disease and early stage diagnosis through the primary healthcare system
Background: Diagnosing Parkinson's disease remains one of the challenging tasks in modern neurology. Over the course of 10 years after the onset of the disease, 65% of patients become severely disabled. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Akramova, G. Rakhimbaeva, D. Bobamuratova, S.-J. Khamdamov Source Type: research
Burden, anxiety and depression among caregivers of Parkinson's patients
Background: Parkinson's Disease (PD) poses mortality risks reducing life expectancy and leads to disability causing dependence in daily activities. Caregivers, often relatives, face mental health challenges. Our study is the first to explore caregiver burden and psychiatric illnesses in PD care in Saudi Arabia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Alshoumar, S. Alshimemeri, H. AlSudais, N. Alamri, S. Bin Dher, M.H. Maashi Source Type: research
Impact of Falls on Quality of Life among Patients with Parkinson ’s Disease from a Referral Center Ambulatory Care PD Clinic
This study aims to assess the effect of falls on the QoL of PwP based on the Parkinson Disease Questionnaire 8 (PDQ-8) score. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.R.T. Yu, A.D.L. Sarmiento, M. Cua, M.J. Tanglao, R.L. Rosales Source Type: research
Adult-onset dystonic opisthotonus associated with DLG4-related synaptopathy
Background: DLG4-related synaptopathy is a rare autosomal dominant brain disorder associated with pathogenic variants of the DLG4 gene, which encodes the postsynaptic density protein of excitatory neurons PSD-95. The clinical phenotype encompasses epilepsy, developmental delay, intellectual disability, behavioral problems, autism, dysmorphic and marfanoid features. Dystonia and other movement disorders have been described as occurring in this condition, but not well characterized. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T. De Santis, P. Polverino, A. Cocco, S. Lalli, E.M. Valente, A. Albanese Source Type: research
Epidemiological Disparities and Challenges in Non-Parkinsonian Tremor Disorders Research
Background: Non-parkinsonian tremors encompass a spectrum of heterogeneous movement disorders where critical knowledge gaps exist in the Indian context regarding contemporary epidemiological trends, underlying pathophysiology, psychiatric comorbidity burden, and impact on disability and quality of life. This scoping review consolidates an evaluation of literature across these domains. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Desai, S. Udwani Source Type: research
Cerebrotendinous Xanthomatosis: Understanding Neurological Manifestations Through Physical Exam Video
Background: Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage caused by mutations in the CYP27A1 gene, leading to cholesterol and cholestanol accumulation in lipophilic tissues. Neurological symptoms encompass intellectual disability, cognitive impairments, pyramidal signs, progressive ataxia, and dystonia, among others, while non-neurological manifestations include childhood-onset cataracts, tendon xanthomas, and diarrhea. Diagnostic delay, averaging 16 years due to its low prevalence, poses a significant challenge. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Villa Lopez, T. Sugumar, O. Suchowersky Source Type: research
