Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review
AbstractOne of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative and disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute to the development of OA. Dysbiosis of GM can disrupt the “symphony” between the host and the GM, leading to a host immunological response that activates the “gut–joint” axis,...
Source: Pain and Therapy - April 27, 2024 Category: Anesthesiology Source Type: research
Using a Video Activity Schedule to Teach Cooperative Games to Autistic Children in a Camp Setting
In this study, a non-concurrent multiple baseline design across participants was used to evaluate the effect of a video activity schedule to teach four dyads of autistic children how to play cooperative games during a summer day camp. Results indicate that all participants learned how to play the game, including during generalization and maintenance probes. A limitation within the study was a lack of data collected for social communication and social validity. Future research should collect social communication data and/or other measures like indices of happiness (e.g., smiling, laughing, etc.). (Source: Journal of Develop...
Source: Journal of Developmental and Physical Disabilities - April 27, 2024 Category: Disability Source Type: research
Comparison of Caregivers ’ and Children’s Preference for Mand Topography During Functional Communication Training
AbstractFunctional communication training (FCT; Carr& Durand, 1985) is frequently utilized as a treatment for socially maintained problem behavior (Tiger et al., 2008). Although FCT is a viable treatment option for the reduction of problem behavior, researchers have identified several variables related to the selection of the functional communication response (FCR) topography that may influence treatment outcomes, including individual and caregiver preference. However, there may be times in which the target individual and caregiver preference do not match. Given this, there is a need for procedures to identify and comp...
Source: Journal of Developmental and Physical Disabilities - April 27, 2024 Category: Disability Source Type: research
Case Study: The Weighty Issue of Treatment Options for Obese Dialysis Patients
We report on a successful bariatric surgery with a young adult after 5.5 years on dialysis with hope for a future transplant. Success was demonstrated with progressive weight loss without adverse changes in renal clinical markers accompanied by improvements in exercise tolerance and health status thereby improving her suitability for a kidney transplant. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - April 27, 2024 Category: Urology & Nephrology Authors: Desiree de Waal, Macaulay Onuigbo, Thomas Alan Golper Tags: Case Studies Source Type: research
Long ‐lasting symptoms in borderline personality disorder: Defining an emergent population with differential clinical and therapeutic features
AbstractAlthough the clinical symptoms of borderline personality disorder (BPD) tend to remit over time, a substantial proportion continues to present “long-lasting symptoms” (LLS). This term refers to individuals who present some degree of clinical improvement, but low mood, feelings of emptiness, and poor psychosocial adjustment typically persist. The aim of this study was to compare the sociodemographic, clinical, and therapeutic variables in individuals with BPD with and without LLS. A total of 620 participants with BPD were included and subdivided into two groups: non-LLS group (n = 549, mean age = 28.02 [...
Source: Personality and Mental Health - April 26, 2024 Category: Psychiatry Authors: Elisabet Casellas ‐Pujol,
Joaquim Soler,
Carlos Schmidt,
Jose Soriano,
Juan C. Pascual Tags: RESEARCH ARTICLE Source Type: research
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.05...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Ann Francis Simon Erridge Carl Holvey Ross Coomber Wendy Holden James Rucker Michael Platt Mikael Sodergren Source Type: research
The Arabic psychosocial impact of assistive devices scale: Development, translation, and evaluation
Assist Technol. 2024 Apr 26:1-8. doi: 10.1080/10400435.2024.2339467. Online ahead of print.ABSTRACTThis paper describes the development, translation, and early evaluation of the Arabic Psychosocial Impact of Assistive Devices Scale (AR-PIADS), an outcome measure instrument for the subjective impact of Assistive Technology on a person with a disabilities' quality of life. Developing the AR = PIADS instrument involved forward and backward translation by two independent teams of bilingual, Arabic-English speakers (n = 5) and a quality and usability review by a panel of people with disabilities (n = 18). The emergent version w...
Source: Assistive Technology - April 26, 2024 Category: Rehabilitation Authors: Bryan Boyle Inmaculada Arnedillo-Sanchez Aejaz Zahid Yvonne Pennisi Source Type: research
Development and content validity of the caregiver assisted transfer technique instrument
Assist Technol. 2024 Apr 26:1-9. doi: 10.1080/10400435.2024.2336334. Online ahead of print.ABSTRACTInformal caregivers often provide transfer assistance to individuals with disabilities; however, repeated transfers are associated with a high risk of musculoskeletal pain and injury, and training and education around transfers is minimal. The purpose of this study was to develop and assess the content validity of a new tool, the Caregiver Assisted Transfer Technique Instrument (CATT), which could be used to provide an objective indicator of transfer performance. Item importance, clarity, and appropriateness of responses were...
Source: Assistive Technology - April 26, 2024 Category: Rehabilitation Authors: Hailee R Kulich Diane Collins Brad E Dicianno Luci Leykum Lynn Worobey Rory Cooper Alicia M Koontz Source Type: research
Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection-A Narrative Review
Curr Issues Mol Biol. 2024 Apr 4;46(4):3122-3133. doi: 10.3390/cimb46040196.ABSTRACTWorldwide, approximately 15 million people per year suffer from stroke. With about 5 million deaths, stroke is the second most common cause of death and a major cause of long-term disability. It is estimated that about 25% of people older than 85 years will develop stroke. Cannabis sativa and derived cannabinoids have been used for recreational and medical purposes for many centuries. However, due to the legal status in the past, research faced restrictions, and cannabis use was stigmatized for potential negative impacts on health. With the...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Caroline Carter Lindsay Laviolette Bashir Bietar Juan Zhou Christian Lehmann Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
Dorsal wrist plating for the management of intra-articular distal radius fractures
Acta Orthop Belg. 2024 Mar;90(1):110-114. doi: 10.52628/90.1.8058.ABSTRACTThe aim of the study was to evaluate the results of Dorsal Wrist Plating in intra-articular distal radius fractures with a dorsal displacement. In this prospective study, a single surgeon treated 20 patients with a (partially) intra-articular distal radius fracture with a dorsal rim avulsion or a dorsal Barton's type fragment. They all underwent an open reduction and internal fixation by Dorsal Wrist Plating. A total of 17 patients had a follow-up period of at least 12 months (mean follow- up of 17 months) and these patients were included in the stud...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: J Brauns W Vandesande Source Type: research
De Quervain's tenosynovitis as an occupational disease in agricultural worker: A case report
CONCLUSIONS: Report shows that work-related factors were strongly associated with diagnosed de Quervain's tenosynovitis. Hand function plays an essential role in carrying out activities of daily living and this disorder pose a relevant burden of disease. Exposure to biomechanical factors should be an important initial target for the prevention of De Quervain's tenosynovitis in the working population.PMID:38669502 | DOI:10.3233/WOR-230135 (Source: Work)
Source: Work - April 26, 2024 Category: Occupational Health Authors: Sonja Medic-Pericevic Ivan Mikov Milorad Spanovic Nada Maric Jelena Zvekic-Svorcan Rastislava Krasnik Source Type: research
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.05...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Ann Francis Simon Erridge Carl Holvey Ross Coomber Wendy Holden James Rucker Michael Platt Mikael Sodergren Source Type: research
Protective factors against depression in high-risk children and adolescents: a systematic review of longitudinal studies
Braz J Psychiatry. 2024 Apr 26. doi: 10.47626/1516-4446-2023-3363. Online ahead of print.ABSTRACTBACKGROUND: Depression is a significant global disability, and early adverse experiences (EAE) represent consistent risk factors in children. However, protective factors play a vital role in promoting healthy development and mitigating these risks.METHODS: We conducted a thorough literature search on Pubmed, APA, Emcare, and EMBASE from 1946 to August 25, 2023. We included longitudinal studies analyzing protective factors for depressive symptoms in high-risk children or adolescents, excluding cross-sectional studies, reviews, a...
Source: Revista Brasileira de Psiquiatria - April 26, 2024 Category: Psychiatry Authors: B árbara Tietbohl-Santos Augusto Ossamu Shintani Bruno Braga Montezano Paola Biazin Giovanna Maiolli Signori Rafaela Pulice Giancarlo Franceschi Dalla Vecchia J úlio César Bebber Lucas Noronha Ives Cavalcante Passos Source Type: research
Development and content validity of the caregiver assisted transfer technique instrument
Assist Technol. 2024 Apr 26:1-9. doi: 10.1080/10400435.2024.2336334. Online ahead of print.ABSTRACTInformal caregivers often provide transfer assistance to individuals with disabilities; however, repeated transfers are associated with a high risk of musculoskeletal pain and injury, and training and education around transfers is minimal. The purpose of this study was to develop and assess the content validity of a new tool, the Caregiver Assisted Transfer Technique Instrument (CATT), which could be used to provide an objective indicator of transfer performance. Item importance, clarity, and appropriateness of responses were...
Source: Assistive Technology - April 26, 2024 Category: Rehabilitation Authors: Hailee R Kulich Diane Collins Brad E Dicianno Luci Leykum Lynn Worobey Rory Cooper Alicia M Koontz Source Type: research
