Sociodemographic factors linked to food allergy diagnosis among high-risk children with atopic dermatitis
CONCLUSION: Labeling at-risk young children with food allergy without thorough objective testing can impact their nutrition and quality of life. Barriers to equitable evaluation of food allergy diagnosis should be further investigated and addressed.PMID:38648973 | DOI:10.1016/j.anai.2024.04.016 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Ellen Daily Stephen Sven Wang Manali Shah Anandu Dileep Shannon Manz Niki Mirhosseini Mahboobeh Mahdavinia Source Type: research
Nanopore Long-Read Sequencing Solves the Conundrum of FLG Genetics
Loss-of-function (LoF) variants resulting in stop codons in FLG are causative for ichthyosis vulgaris (IV) (Smith et al, 2006). FLG LoF is also a major risk factor for developing atopic dermatitis (AD) (Palmer et al, 2006). However, reports of mild AD in compound heterozygote individuals suggest that these LoF may be in cis (same allele) and the other allele to be normal. To further complicate FLG genetics, eac h FLG allele is comprised of either 10, 11, or 12 repeats, with each additional repeat decreasing the odds of AD (Brown et al, 2012). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 22, 2024 Category: Dermatology Authors: Pedro S. Bonilla, Cristina de Guzman Strong Tags: Commentary Source Type: research
Does Molluscum Contagiosum Need to be Managed Differently in Atopic Children?
Acta Derm Venereol. 2024 Apr 20;104:adv39983. doi: 10.2340/actadv.v104.39983.ABSTRACTThe association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.17% of whom had atopic dermatitis. While the latter group exhibited higher lesion count and itchiness (p=0.026 and p=0.044, respectively), no significant dif...
Source: Acta Dermato-Venereologica - April 21, 2024 Category: Dermatology Authors: Nicolas Andre Adva Alyagon Eman Jurban Khen Moscovici Amir Horev Source Type: research
Does Molluscum Contagiosum Need to be Managed Differently in Atopic Children?
Acta Derm Venereol. 2024 Apr 20;104:adv39983. doi: 10.2340/actadv.v104.39983.ABSTRACTThe association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.17% of whom had atopic dermatitis. While the latter group exhibited higher lesion count and itchiness (p=0.026 and p=0.044, respectively), no significant dif...
Source: Acta Derm Venereol A... - April 21, 2024 Category: Dermatology Authors: Nicolas Andre Adva Alyagon Eman Jurban Khen Moscovici Amir Horev Source Type: research
Label-free cell phenotypic profiling of histamine H4R receptor and discovery of non-competitive H4R antagonist from natural products
Bioorg Chem. 2024 Apr 18;147:107387. doi: 10.1016/j.bioorg.2024.107387. Online ahead of print.ABSTRACTHistamine 4 receptor (H4R), the most recently identified subtype of histamine receptor, primarily induces inflammatory reactions upon activation. Several H4R antagonists have been developed for the treatment of inflammatory bowel disease (IBD) and atopic dermatitis (AD), but their use has been limited by adverse side effects, such as a short half-life and toxicity. Natural products, as an important source of anti-inflammatory agents, offer minimal side effects and reduced toxicity. This work aimed to identify novel H4R ant...
Source: Bioorganic Chemistry - April 21, 2024 Category: Chemistry Authors: Hongming Tang Tao Hou Han Zhou Han Liao Fangfang Xu Xiaomin Xie Wenjie Yuan Zhixin Guo Yanfang Liu Jixia Wang Weijia Zhou Xinmiao Liang Source Type: research
Does Molluscum Contagiosum Need to be Managed Differently in Atopic Children?
Acta Derm Venereol. 2024 Apr 20;104:adv39983. doi: 10.2340/actadv.v104.39983.ABSTRACTThe association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.17% of whom had atopic dermatitis. While the latter group exhibited higher lesion count and itchiness (p=0.026 and p=0.044, respectively), no significant dif...
Source: Acta Derm Venereol A... - April 21, 2024 Category: Dermatology Authors: Nicolas Andre Adva Alyagon Eman Jurban Khen Moscovici Amir Horev Source Type: research
Does Molluscum Contagiosum Need to be Managed Differently in Atopic Children?
Acta Derm Venereol. 2024 Apr 20;104:adv39983. doi: 10.2340/actadv.v104.39983.ABSTRACTThe association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.17% of whom had atopic dermatitis. While the latter group exhibited higher lesion count and itchiness (p=0.026 and p=0.044, respectively), no significant dif...
Source: Acta Dermato-Venereologica - April 21, 2024 Category: Dermatology Authors: Nicolas Andre Adva Alyagon Eman Jurban Khen Moscovici Amir Horev Source Type: research
Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33
ConclusionThe study suggests that CoTX has anti-allergic and anti-inflammatory effects in allergic AD. By targeting IL-33 and IgE pathways, CoTX demonstrated potential in regulating mast cell activation and inflammatory cytokine production. The observed improvements in the AD mouse model indicate CoTX as a promising candidate for further research towards developing effective and safe treatments for AD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 21, 2024 Category: Cytology Source Type: research
Dupilumab provides sustained effectiveness on patient-reported outcomes and favorable safety in patients with moderate-to-severe atopic dermatitis: up to 5-year results from the daily practice BioDay Registry
Long-term daily practice data on patient-reported benefits of dupilumab for atopic dermatitis (AD) remains limited. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2024 Category: Dermatology Authors: Junfen Zhang, Celeste M. Boesjes, Laura Loman, Esm é Kamphuis, Margreet L.E. Romeijn, Lotte S. Spekhorst, Inge Haeck, Lian F. van der Gang, Coco C. Dekkers, Lisa P. van der Rijst, Albert J. Oosting, Paula van Lumig, Anneke M.T. van Lynden-van Nes, Ron A. Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
Assisted reproductive techniques and subsequent risk of asthma and allergic rhinitis in offspring: a nationwide birth cohort study in South Korea
CONCLUSIONS: Our study offers important insights for clinicians, researchers, and parents regarding the health outcomes of ART-conceived infants and enhances our understanding of ART's impact on respiratory health.PMID:38639513 | DOI:10.26355/eurrev_202404_35902 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: S H Kim M Kim H Lee S Woo H J Kim A Koyanagi L Smith M S Kim H K Min J-Y Min D K Yon Source Type: research
Assisted reproductive techniques and subsequent risk of asthma and allergic rhinitis in offspring: a nationwide birth cohort study in South Korea
CONCLUSIONS: Our study offers important insights for clinicians, researchers, and parents regarding the health outcomes of ART-conceived infants and enhances our understanding of ART's impact on respiratory health.PMID:38639513 | DOI:10.26355/eurrev_202404_35902 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: S H Kim M Kim H Lee S Woo H J Kim A Koyanagi L Smith M S Kim H K Min J-Y Min D K Yon Source Type: research
