Evaluating the Clinical Meaning of Dermatology Life Quality Index Scores Between Different Phenotypes of Atopic Dermatitis in Patients Before and After Biologic Therapy With Dupilumab
Conclusions: Quality of life is probably what matters most as an overall endpoint in AD. Assessing the clinical meaning of DLQI scores across different AD phenotypes could be a further aid when considering decision making factors in patient management.PMID:38669092 | DOI:10.1089/derm.2023.0357 (Source: Dermatitis)
Source: Dermatitis - April 26, 2024 Category: Dermatology Authors: Filomena Russo Vittoria Cioppa Laura Lazzeri Nicola Milanesi Marco Galluzzo Angelo Massimiliano D'Erme Natale Schettini Barbara Cocuroccia Donatella Sordi Annarita Panebianco Marina Talamonti Claudia Paganini Ornella De Pit à Anna Rita Giampetruzzi Giova Source Type: research
Angiosarcoma Mimicking Allergic Contact Dermatitis and Response to Timolol
Dermatitis. 2024 Apr 26. doi: 10.1089/derm.2023.0129. Online ahead of print.NO ABSTRACTPMID:38669093 | DOI:10.1089/derm.2023.0129 (Source: Dermatitis)
Source: Dermatitis - April 26, 2024 Category: Dermatology Authors: Tenzin Serpolamatsang Kimberly Arrington Samantha Gardeen Joseph A Scherman Source Type: research
Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Curr Issues Mol Biol. 2024 Mar 30;46(4):2975-2990. doi: 10.3390/cimb46040186.ABSTRACTThe evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Isabella J Tan Alicia Podwojniak Aarushi Parikh Bernard A Cohen Source Type: research
Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor- α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells
Curr Issues Mol Biol. 2024 Apr 18;46(4):3470-3483. doi: 10.3390/cimb46040218.ABSTRACTAtopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Ye Jin Kwon Hyun Hee Kwon Jaechan Leem Yoon Young Jang Source Type: research
Evaluating the Clinical Meaning of Dermatology Life Quality Index Scores Between Different Phenotypes of Atopic Dermatitis in Patients Before and After Biologic Therapy With Dupilumab
Conclusions: Quality of life is probably what matters most as an overall endpoint in AD. Assessing the clinical meaning of DLQI scores across different AD phenotypes could be a further aid when considering decision making factors in patient management.PMID:38669092 | DOI:10.1089/derm.2023.0357 (Source: Dermatitis)
Source: Dermatitis - April 26, 2024 Category: Dermatology Authors: Filomena Russo Vittoria Cioppa Laura Lazzeri Nicola Milanesi Marco Galluzzo Angelo Massimiliano D'Erme Natale Schettini Barbara Cocuroccia Donatella Sordi Annarita Panebianco Marina Talamonti Claudia Paganini Ornella De Pit à Anna Rita Giampetruzzi Giova Source Type: research
Angiosarcoma Mimicking Allergic Contact Dermatitis and Response to Timolol
Dermatitis. 2024 Apr 26. doi: 10.1089/derm.2023.0129. Online ahead of print.NO ABSTRACTPMID:38669093 | DOI:10.1089/derm.2023.0129 (Source: Dermatitis)
Source: Dermatitis - April 26, 2024 Category: Dermatology Authors: Tenzin Serpolamatsang Kimberly Arrington Samantha Gardeen Joseph A Scherman Source Type: research
Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Curr Issues Mol Biol. 2024 Mar 30;46(4):2975-2990. doi: 10.3390/cimb46040186.ABSTRACTThe evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Isabella J Tan Alicia Podwojniak Aarushi Parikh Bernard A Cohen Source Type: research
Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor- α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells
Curr Issues Mol Biol. 2024 Apr 18;46(4):3470-3483. doi: 10.3390/cimb46040218.ABSTRACTAtopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Ye Jin Kwon Hyun Hee Kwon Jaechan Leem Yoon Young Jang Source Type: research
Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis
ConclusionThe most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 26, 2024 Category: Cancer & Oncology Source Type: research
Macrophage polarization: an important role in inflammatory diseases
Front Immunol. 2024 Apr 10;15:1352946. doi: 10.3389/fimmu.2024.1352946. eCollection 2024.ABSTRACTMacrophages are crucial cells in the human body's innate immunity and are engaged in a variety of non-inflammatory reactions. Macrophages can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages and anti-inflammatory M2-type macrophages. During inflammation, the two kinds of macrophages are activated alternatively, and maintaining a reasonably steady ratio is critical for maintaining homeostasis in vivo. M1 macrophages can induce inflammation, but M2 macrophages suppress...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Min Luo Fukun Zhao Huan Cheng Mu Su Yuanmin Wang Source Type: research
Emerging drugs for the treatment of atopic dermatitis: a focus on phase 2 and phase 3 trials
Expert Opin Emerg Drugs. 2024 Apr 25. doi: 10.1080/14728214.2024.2345643. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis (AD) is an inflammatory skin condition that affects millions of pediatric and adult patients with well-studied impact on morbidity and quality of life. Management occurs in a stepwise fashion beginning with preventative measures before immunomodulators are introduced. However, challenges remain in treatment of moderate to severe atopic dermatitis that is refractory to first and second-line treatments and there are only few topical anti-inflammatory options, especially for pediatric patient...
Source: Expert Opinion on Emerging Drugs - April 25, 2024 Category: Drugs & Pharmacology Authors: Ogechi Obed Albert C Chong Malcolm Su Peck Y Ong Source Type: research
Eczema Coxsackium: Atypical Manifestations in the Comorbidity of Atopic Dermatitis With Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in a Pediatric Case
Dermatitis. 2024 Apr 25. doi: 10.1089/derm.2024.0031. Online ahead of print.NO ABSTRACTPMID:38662460 | DOI:10.1089/derm.2024.0031 (Source: Dermatitis)
Source: Dermatitis - April 25, 2024 Category: Dermatology Authors: Mutong Zhao Xu Li Lin Ma Source Type: research
Emerging drugs for the treatment of atopic dermatitis: a focus on phase 2 and phase 3 trials
Expert Opin Emerg Drugs. 2024 Apr 25. doi: 10.1080/14728214.2024.2345643. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis (AD) is an inflammatory skin condition that affects millions of pediatric and adult patients with well-studied impact on morbidity and quality of life. Management occurs in a stepwise fashion beginning with preventative measures before immunomodulators are introduced. However, challenges remain in treatment of moderate to severe atopic dermatitis that is refractory to first and second-line treatments and there are only few topical anti-inflammatory options, especially for pediatric patient...
Source: Expert Opinion on Emerging Drugs - April 25, 2024 Category: Drugs & Pharmacology Authors: Ogechi Obed Albert C Chong Malcolm Su Peck Y Ong Source Type: research
Effectiveness of atopic dermatitis patient education programs – a systematic review and meta-analysis
In this study, we conducted a systematic review of the literature to determine the effectiveness of online programming in AD education compared to in-person interventions. A comprehensive search was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions 2019. Studies were retrieved based on articles published up to 04 April 2023. Adherence to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement guided the reportage process for this systematic review and meta-analysis. The primary outcome of our meta-analysis was the effect of various educational modali...
Source: Archives of Dermatological Research - April 25, 2024 Category: Dermatology Source Type: research
Interleukin antagonists for atopic dermatitis: a new era of therapy
Expert Opin Investig Drugs. 2024 Apr 24. doi: 10.1080/13543784.2024.2347294. Online ahead of print.ABSTRACTINTRODUCTION: Over the last decade, increasing understanding of the immunopathogenesis of atopic dermatitis (AD) enabled the recognition of multiple therapeutic targets and subsequently the development of novel, highly effective systemic treatments, including interleukin (IL)-antagonists. To date, the IL-4Ra-inhibitor dupilumab, and the IL-13 inhibitor tralokinumab, have gained regulatory approval in Europe for the treatment of moderate-to-severe AD, while more than 70 new therapeutics are currently in development.ARE...
Source: Expert Opinion on Investigational Drugs - April 24, 2024 Category: Drugs & Pharmacology Authors: Aikaterini Tsiogka Eleni Paschou Dimitra Koumaki Efstratios Vakirlis Stamatios Gregoriou Source Type: research
