Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells
This study investigated the immunotoxic effects of the mycotoxin nivalenol (NIV) using antigen-presenting cells and a mouse model of atopic dermatitis (AD). In vitro experiments were conducted using a mouse macrophage cell line (RAW 264.7) and mouse dendritic cell line (DC 2.4). After cells were exposed to NIV (0.19-5 µmol) for 24 h, the production of pro-inflammatory cytokines (IL-1β, IL-6, and TNFα) was quantified. To further investigate the inflammatory cytokine production pathway, the possible involvement of mitogen-activated protein kinase (MAPK) pathways, such as ERK1/2, p-38, and JNK, in NIV exposure was analyzed...
Source: Archives of Toxicology - April 14, 2024 Category: Toxicology Authors: Reo Matsuzaka Hiroki Yamaguchi Chiharu Ohira Tomoe Kurita Naoki Iwashita Yoshiichi Takagi Tomomi Nishino Kyoko Noda Kazutoshi Sugita Masayo Kushiro Shiro Miyake Tomoki Fukuyama Source Type: research
Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis
ConclusionThe results of this analysis demonstrate that, in combination with TCS, tralokinumab and dupilumab have similar efficacy in the treatment of moderate-to-severe AD at 32 weeks of therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 13, 2024 Category: Dermatology Source Type: research
Diagnosis of a recurred lesion in dermatophytosis patients after 2 weeks of antifungal therapy: A prospective observational study
CONCLUSION: This is the first study that described the clinical diagnosis and mycological profile of the various lesions recurring at the previous tinea infection site in patients with dermatophytosis. Such patients presented not only with recurrent lesions of fungal infection but also developed various dermatoses unrelated to fungal infection at the sites of previous tinea infection. Various factors, which could have resulted in the observed changes, are reinfection by dermatophytes at the sites of previous tinea infection, inadequate antifungal therapy or antifungal resistance; or due to the effects of various topical st...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Chandra S Sirka Bijayini Behera Swetalina Pradhan Arpita N Rout Kananbala Sahu Gaurav Dash Jayanti Jena Source Type: research
Impact of chrono-radiotherapy on the prognosis and treatment-related toxicity in patients with locally advanced nasopharyngeal carcinoma: A multicenter propensity-matched study
Chronobiol Int. 2024 Apr 12:1-11. doi: 10.1080/07420528.2024.2337887. Online ahead of print.ABSTRACTThe timing of radiotherapy (RT) delivery has been reported to affect both cancer survival and treatment toxicity. However, the association among the timing of RT delivery, survival, and toxicity in locally advanced nasopharyngeal carcinoma (LA-NPC) has not been investigated. We retrospectively reviewed patients diagnosed with LA-NPC who received definitive RT at multiple institutions. The median RT delivery daytime was categorized as morning (DAY) and night (NIGHT). Seasonal variations were classified into the darker half of...
Source: Chronobiology International - April 12, 2024 Category: Biology Authors: Jie Lin Xiantao Lin Rong Zheng Kehai Lin Muhammad Khan Xiuting Huang Yunhong Tian Baiyao Wang BenHua Xu Yawei Yuan Zhong Huang Source Type: research
Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research
Reappraising the Use of Systemic Immunomodulators for Psoriasis and Eczema in the Military
CONCLUSIONS: Systemic treatments have evolved to become highly specific for both eczema and psoriasis. These newer biologics and immunomodulators may be compatible with use in the deployed setting, especially those that have long dosing intervals and proven efficacy and safety. Of the biologics, dupilumab and risankizumab offer the best efficacy, safety, and dosing intervals for atopic dermatitis and psoriasis, respectively. Deucravcitinib is a recently FDA-approved oral immunomodulator for psoriasis that has an excellent safety profile and efficacy. Allowing the use of these medications on deployments will enable more peo...
Source: Military Medicine - April 12, 2024 Category: International Medicine & Public Health Authors: Alexius Russell Samantha Williamson Alexandra Rosenberg Sunghun Cho Source Type: research
Treatment of Netherton Syndrome in Pediatrics with Upadacitinib
CONCLUSIONS: Initiation of Upadacitinib at a daily dose of 15 mg yielded significant therapeutic benefits within a short timeframe. This study marks the first documented use of Upadacitinib in pediatric Netherton syndrome treatment. This case highlights the efficacy of Upadacitinib in treating Netherton syndrome, particularly in pediatric patients. Further studies are warranted to elucidate its long-term effects and optimal dosing regimens.PMID:38607195 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Cuicui Sun Yongfeng Chen Source Type: research
Diagnosis of a recurred lesion in dermatophytosis patients after 2 weeks of antifungal therapy: A prospective observational study
CONCLUSION: This is the first study that described the clinical diagnosis and mycological profile of the various lesions recurring at the previous tinea infection site in patients with dermatophytosis. Such patients presented not only with recurrent lesions of fungal infection but also developed various dermatoses unrelated to fungal infection at the sites of previous tinea infection. Various factors, which could have resulted in the observed changes, are reinfection by dermatophytes at the sites of previous tinea infection, inadequate antifungal therapy or antifungal resistance; or due to the effects of various topical st...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Chandra S Sirka Bijayini Behera Swetalina Pradhan Arpita N Rout Kananbala Sahu Gaurav Dash Jayanti Jena Source Type: research
Diagnosis of a recurred lesion in dermatophytosis patients after 2 weeks of antifungal therapy: A prospective observational study
CONCLUSION: This is the first study that described the clinical diagnosis and mycological profile of the various lesions recurring at the previous tinea infection site in patients with dermatophytosis. Such patients presented not only with recurrent lesions of fungal infection but also developed various dermatoses unrelated to fungal infection at the sites of previous tinea infection. Various factors, which could have resulted in the observed changes, are reinfection by dermatophytes at the sites of previous tinea infection, inadequate antifungal therapy or antifungal resistance; or due to the effects of various topical st...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Chandra S Sirka Bijayini Behera Swetalina Pradhan Arpita N Rout Kananbala Sahu Gaurav Dash Jayanti Jena Source Type: research
Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research
Treatment of Netherton Syndrome in Pediatrics with Upadacitinib
CONCLUSIONS: Initiation of Upadacitinib at a daily dose of 15 mg yielded significant therapeutic benefits within a short timeframe. This study marks the first documented use of Upadacitinib in pediatric Netherton syndrome treatment. This case highlights the efficacy of Upadacitinib in treating Netherton syndrome, particularly in pediatric patients. Further studies are warranted to elucidate its long-term effects and optimal dosing regimens.PMID:38607195 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Cuicui Sun Yongfeng Chen Source Type: research
Impact of chrono-radiotherapy on the prognosis and treatment-related toxicity in patients with locally advanced nasopharyngeal carcinoma: A multicenter propensity-matched study
Chronobiol Int. 2024 Apr 12:1-11. doi: 10.1080/07420528.2024.2337887. Online ahead of print.ABSTRACTThe timing of radiotherapy (RT) delivery has been reported to affect both cancer survival and treatment toxicity. However, the association among the timing of RT delivery, survival, and toxicity in locally advanced nasopharyngeal carcinoma (LA-NPC) has not been investigated. We retrospectively reviewed patients diagnosed with LA-NPC who received definitive RT at multiple institutions. The median RT delivery daytime was categorized as morning (DAY) and night (NIGHT). Seasonal variations were classified into the darker half of...
Source: Chronobiology International - April 12, 2024 Category: Biology Authors: Jie Lin Xiantao Lin Rong Zheng Kehai Lin Muhammad Khan Xiuting Huang Yunhong Tian Baiyao Wang BenHua Xu Yawei Yuan Zhong Huang Source Type: research
Treatment of Netherton Syndrome in Pediatrics with Upadacitinib
CONCLUSIONS: Initiation of Upadacitinib at a daily dose of 15 mg yielded significant therapeutic benefits within a short timeframe. This study marks the first documented use of Upadacitinib in pediatric Netherton syndrome treatment. This case highlights the efficacy of Upadacitinib in treating Netherton syndrome, particularly in pediatric patients. Further studies are warranted to elucidate its long-term effects and optimal dosing regimens.PMID:38607195 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Cuicui Sun Yongfeng Chen Source Type: research
HIV-related exclusion criteria in atopic dermatitis and prurigo nodularis clinical trials
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 12, 2024 Category: Dermatology Authors: Rebecca Leibowitz, Anna Fischer, Lauren F. Collins, Ron J. Feldman, Howa Yeung Source Type: research
