Adverse events in biologics for severe asthma
CONCLUSION: Biologics for severe asthma are recent drugs with a favorable safety profile, but with little real-life experience, justifying increased vigilance by prescribing physicians.PMID:38653607 | DOI:10.1016/j.rmr.2024.04.001 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 23, 2024 Category: Respiratory Medicine Authors: G Dargentolle M Georges G Beltramo C Poisson P Bonniaud Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2024 Category: Dermatology Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Adverse events in biologics for severe asthma
CONCLUSION: Biologics for severe asthma are recent drugs with a favorable safety profile, but with little real-life experience, justifying increased vigilance by prescribing physicians.PMID:38653607 | DOI:10.1016/j.rmr.2024.04.001 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 23, 2024 Category: Respiratory Medicine Authors: G Dargentolle M Georges G Beltramo C Poisson P Bonniaud Source Type: research
Identifying atopic dermatitis risk loci in 1,094,060 individuals with sub analysis of disease severity and onset
Atopic dermatitis (AD) is a common inflammatory skin disease highly attributable to genetic factors. Here, we report results from a genome-wide meta-analysis of AD in 37,541 cases and 1,056,519 controls with data from the FinnGen project, the Estonian Biobank, the UK Biobank, the EAGLE Consortium, and the BioBank Japan. We detected 77 independent AD-associated loci of which 10 were to our knowledge previously unreported. The associated loci showed enrichment in various immune regulatory processes. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 23, 2024 Category: Dermatology Authors: Anu Pasanen, Eeva Sliz, Laura Huilaja, FinnGen, Estonian Biobank Research Team, Ene Reimann, Reedik M ägi, Triin Laisk, Kaisa Tasanen, Johannes Kettunen Tags: Original Article Source Type: research
Economic Burden of Itch-Related Sleep Loss in Moderate-to-Severe Atopic Dermatitis in the United Kingdom
ConclusionsSleep disruption has a high economic burden and reducing itch may provide substantial direct and indirect savings. Quantifying the economic burden of itch-related sleep loss may provide support for analyses to inform public health policies for treatment of atopic dermatitis, particularly within the moderate-to-severe level. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 23, 2024 Category: Dermatology Source Type: research
Sociodemographic factors linked to food allergy diagnosis among high-risk children with atopic dermatitis
CONCLUSION: Labeling at-risk young children with food allergy without thorough objective testing can impact their nutrition and quality of life. Barriers to equitable evaluation of food allergy diagnosis should be further investigated and addressed.PMID:38648973 | DOI:10.1016/j.anai.2024.04.016 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Ellen Daily Stephen Sven Wang Manali Shah Anandu Dileep Shannon Manz Niki Mirhosseini Mahboobeh Mahdavinia Source Type: research
[[Translated article]]Allergic Contact Dermatitis to Topical Ophthalmic Drugs: Review of Frequently Used Allergens in Spain
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00356-9. doi: 10.1016/j.ad.2024.04.015. Online ahead of print.ABSTRACTAllergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the al...
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: M D Pegalajar-Garc ía B A Coronel-Gonz ález F J Navarro-Trivi ño Source Type: research
[[Translated article]Tralokinumab in Atopic Dermatitis: Real-Life Data from a Spanish Tertiary Referral Center
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00348-X. doi: 10.1016/j.ad.2024.04.008. Online ahead of print.NO ABSTRACTPMID:38648932 | DOI:10.1016/j.ad.2024.04.008 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: C M Dom ínguez Santana M Viedma-Mart ínez E R íos Sánchez Source Type: research
[[Translated article]]Epidemiological, Clinical, and Allergic Profile of Psoriatic Patients. Evaluation of the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC)
CONCLUSIONS: Overall, 36.2% of psoriatic patients tested positive in PT to the 2022 Spanish battery of allergens, which proved that this association is not uncommon. Overall, psoriatic patients had a higher mean age, were more predominantly men, and showed more hand involvement.PMID:38648935 | DOI:10.1016/j.ad.2024.04.013 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: J Verdaguer-Faja L Borrego P Mercader-Garc ía R Gonz ález Pérez S C órdoba-Guijarro A M Gim énez-Arnau I Ruiz-Gonz ález J Miquel-Miquel J Francisco Silvestre F J Ortiz de Frutos F Tous-Romero T Sanz S ánchez M Rodr íguez-Serna J S ánchez-Pérez E Source Type: research
Sociodemographic factors linked to food allergy diagnosis among high-risk children with atopic dermatitis
CONCLUSION: Labeling at-risk young children with food allergy without thorough objective testing can impact their nutrition and quality of life. Barriers to equitable evaluation of food allergy diagnosis should be further investigated and addressed.PMID:38648973 | DOI:10.1016/j.anai.2024.04.016 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Ellen Daily Stephen Sven Wang Manali Shah Anandu Dileep Shannon Manz Niki Mirhosseini Mahboobeh Mahdavinia Source Type: research
[[Translated article]]Allergic Contact Dermatitis to Topical Ophthalmic Drugs: Review of Frequently Used Allergens in Spain
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00356-9. doi: 10.1016/j.ad.2024.04.015. Online ahead of print.ABSTRACTAllergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the al...
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: M D Pegalajar-Garc ía B A Coronel-Gonz ález F J Navarro-Trivi ño Source Type: research
[[Translated article]Tralokinumab in Atopic Dermatitis: Real-Life Data from a Spanish Tertiary Referral Center
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00348-X. doi: 10.1016/j.ad.2024.04.008. Online ahead of print.NO ABSTRACTPMID:38648932 | DOI:10.1016/j.ad.2024.04.008 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: C M Dom ínguez Santana M Viedma-Mart ínez E R íos Sánchez Source Type: research
[[Translated article]]Epidemiological, Clinical, and Allergic Profile of Psoriatic Patients. Evaluation of the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC)
CONCLUSIONS: Overall, 36.2% of psoriatic patients tested positive in PT to the 2022 Spanish battery of allergens, which proved that this association is not uncommon. Overall, psoriatic patients had a higher mean age, were more predominantly men, and showed more hand involvement.PMID:38648935 | DOI:10.1016/j.ad.2024.04.013 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: J Verdaguer-Faja L Borrego P Mercader-Garc ía R Gonz ález Pérez S C órdoba-Guijarro A M Gim énez-Arnau I Ruiz-Gonz ález J Miquel-Miquel J Francisco Silvestre F J Ortiz de Frutos F Tous-Romero T Sanz S ánchez M Rodr íguez-Serna J S ánchez-Pérez E Source Type: research
Sociodemographic factors linked to food allergy diagnosis among high-risk children with atopic dermatitis
CONCLUSION: Labeling at-risk young children with food allergy without thorough objective testing can impact their nutrition and quality of life. Barriers to equitable evaluation of food allergy diagnosis should be further investigated and addressed.PMID:38648973 | DOI:10.1016/j.anai.2024.04.016 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Ellen Daily Stephen Sven Wang Manali Shah Anandu Dileep Shannon Manz Niki Mirhosseini Mahboobeh Mahdavinia Source Type: research
Nanopore Long-Read Sequencing Solves the Conundrum of FLG Genetics
Loss-of-function (LoF) variants resulting in stop codons in FLG are causative for ichthyosis vulgaris (IV) (Smith et al, 2006). FLG LoF is also a major risk factor for developing atopic dermatitis (AD) (Palmer et al, 2006). However, reports of mild AD in compound heterozygote individuals suggest that these LoF may be in cis (same allele) and the other allele to be normal. To further complicate FLG genetics, eac h FLG allele is comprised of either 10, 11, or 12 repeats, with each additional repeat decreasing the odds of AD (Brown et al, 2012). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 22, 2024 Category: Dermatology Authors: Pedro S. Bonilla, Cristina de Guzman Strong Tags: Commentary Source Type: research
