Behavioral Signatures of High- vs. Low-Lethality Suicidal Behavior During Exploration/Exploitation: A Computational Study
This study used computational modeling to characterize decision-making processes in people with varying medical seriousness of suicidal behavior across two high-risk samples. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Aliona Tsypes, Michael N. Hallquist, Angela Ianni, Alexandre Dombrovski Source Type: research
Formalizing Pavlovian Biases During Probabilistic Aversive Learning for Suicide Prevention
Suicide presents a formidable public health challenge, often eluding early detection due to the unreliability of self-report measures. Our work introduces a computational framework integrating behavioral, cognitive, and neural analyses to better understand suicide vulnerabilities and inform tailored interventions. Specifically, the model space we proposed explores how heightened inhibitory Pavlovian influence can disrupt instrumental control, leading to an active escape bias under stress. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Andreea Diaconescu, Pamina Laessing, Povilas Karvelis, Peter Dayan Source Type: research
Modeling Cortical Dynamics Underlying Hopelessness in the Context of Suicide Risk
A critical need exists to identify objective biomarkers of suicide risk. Hopelessness is a promising proxy for suicide research that is associated with the suicide crisis and does not require reporting suicidal ideation (SI). Here we measured clinical and magnetoencephalography (MEG) correlates of hopelessness in a sample of individuals at risk for suicide. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jessica Gilbert, Dede Greenstein, Carlos Zarate, Elizabeth Ballard Source Type: research
Brain and Peripheral Whole Transcriptome Correlates of Depressive Disorders: Peripheral is Central to the Pathology
The human anterior-insula (Ant-Ins) and subgenual-anterior-cingulate (sgACC) are brain regions that regulate mood, but studies dissecting the molecular neurobiology of this network in mood disorders are sparse. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dhivya Arasappan, Dennis Wylie, Abigail Spears, Simran Shah, Katrina Benjamin, Dayne Mayfield, Pavan K. Auluck, Ajeet Mandal, Yiyin Lui, Nirmala Akula, Stefano Marenco, Paul Rathouz, Francis McMahon, Mbemba Jabbi Tags: SYMPOSIUM Source Type: research
DNA Methylation Biosignature of Suicide Death in the Brains of Individuals With Bipolar Disorder
Suicide death rates are elevated in individuals with bipolar disorder (BD), with past work implicating epigenetic contributions. We aimed to identify brain genome-wide DNA methylation (DNAm) changes associated with suicide death in BD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Salahudeen Mirza, Alexandre Rubinstein, Christopher Busby, Rohit Jha, Alexandra Del Favero-Campbell, Camila Nayane de Carvalho Lima, Apurva Kumar, Mohammad Farhan, Esther Soyebo, Consuelo Walss-Bass, Jair Soares, Gabriel R. Fries Source Type: research
Multi-Omics Profiling of Human Hippocampus Reveals Increased Inflammation and Transcription Instability in Major Depressive Disorder
To decipher hippocampus cellular and molecular changes in major depression (MDD), we sequenced single-nucleus RNA (snRNA-seq) and accessible chromatin (snATAC-seq), spatial RNA (Visium, 10X Genomics) and multiome via deterministic barcoding in intact tissue (DBiT-seq). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yang Xiao, Madeline Mariani, Graham Su, Yanxiang Deng, Cheick A. Sissoko, Tianyu Li, Sai Ma, Zhiliang Bai, Yang Liu, Gorazd Rosoklija, Tingting Wu, Andrew J. Dwork, Rene Hen, J. John Mann, Rong Fan, Kam Leong, Maura Boldrini Source Type: research
Neurophysiological Applications for Estimating Suicide Risk Reduction in a TMS Clinic
Extant literature provides a precision neural circuit based framework for rTMS outcome modeling related to broad depression recovery but has not investigated high-risk symptoms such as co-occurring suicidality. We investigated EEG metrics of neural circuit integrity to predict reduction in CHRT suicide propensity following rTMS using secondary data analysis on clinical outcomes and pre-treatment EEG collected by the Salience TMS clinic in Dallas, TX. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nicholas Murphy, Abu Minhajuddin, Russell Toll, Sanjay Mathew, Manish Jha, Madhukar Trivedi Source Type: research
Association of Active Suicidal Ideation With NIH Toolbox: Findings From the T-RAD Study
This report from the Texas Resilience Against Depression (T-RAD) study evaluated whether behavioral tasks that measure different domains of cognition are associated with symptoms of active suicidal ideation (SI). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Madhukar Trivedi Source Type: research
2. Investigating the Effects of Real-Time Biofeedback Using 7-Tesla MRI for Depression
Major Depressive Disorder (MDD) is a significant public health problem, but current treatments fail at relieving symptoms for many patients. Motivational deficits are a core feature of depression, mediated by dopaminergic projections from the ventral tegmental area (VTA). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Laurel Morris, Jacqueline Beltran, Grace Butler, Emerald Obie, Yael Jacob, James Murrough Source Type: research
10. Shared and Distinct Alterations in Brain Structure of Children and Adolescents with Internalising or Externalising Disorders: Findings From the ENIGMA Antisocial Behavior, ADHD, MDD and Anxiety Working Groups
Externalising and internalising disorders are common in youth but are often studied in isolation, preventing an investigation of the transdiagnostic vulnerability which may underlie them. Using data from the ENIGMA consortium, we conducted a mega-analysis to identify shared and distinct cortical and subcortical alterations between internalising (anxiety disorders and depression) and externalising (attention-deficit/hyperactivity disorder [ADHD] and conduct disorder [CD]) disorders in youth. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sophie Townend, Marlene Staginnus, Yidian Gao, Barbara Franke, Martine Hoogman, Lianne Schmaal, Dick Veltman, Elena Pozzi, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Dan J. Stein, Nic.J.A. van der Wee, Moji Aghajani, Charlotte Cecil, Eduard Klapwijk, Source Type: research
13. Model Comparisons: Evaluating Effects of Depression on Decision-Making vs. Reinforcement Learning in the Probabilistic Reward Task
The Probabilistic Reward Task (PRT) probes the impact of Major Depressive Disorder (MDD) on reinforcement learning (RL), but MDD also affects decision-making. We acquired PRT data from depressed adults twice, fit the data with decision-making and RL models, and studied model psychometrics. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Daniel Dillon, Cristina Cusin, Maurizio Fava, Diego A. Pizzagalli Source Type: research
15. Mapping Between fMRI and Electrophysiological Networks Encoding Depressive Symptoms
Multiple prior imaging studies have implicated a role for network abnormalities in depression. However, it remains unclear the extent to which these imaging findings reflect underlying alterations in neurophysiology and their relationship to depressive symptoms over time. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: John Alvarez, Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motzkin, Melanie Morrison, Leo Sugrue, Kristin Sellers, Andrew Krystal, Andrew Lee Source Type: research
16. Circulating Myeloid-Derived MMP8 in Stress Susceptibility and Depression
Psychosocial stress has profound effects on the body, including the immune system and the brain. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD), the underlying mechanisms are not well understood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Flurin Cathomas, Hsiao-Yun Lin, Kenny Chan, Long Li, Lyonna Parise, Johana Alvarez, Romain Durand-de Cuttoli, Antonio Aubry, Samer Muhareb, Yusuke Shimo, Aarthi Ramakrishnan, Carmen Ferrer Perez, Eric Parise, Manuella Kaster, Jun Wang, Sara Costi, Adeeb R Source Type: research
17. Predictors of Remission After Repetitive Transcranial Magnetic Stimulation for the Treatment of Late-Life Depression
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment in patients with depression, yet treatment response remains variable. While previous work has identified predictors of remission in younger adults, relatively little data exists in late-life depression (LLD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Katharina G öke, Alisson P. Trevizol, Clement Ma, Linda Mah, Tarek K. Rajji, Zafiris J. Daskalakis, Jonathan Downar, Shawn M. McClintock, Sean M. Nestor, Yoshihiro Noda, Daniel M. Blumberger Source Type: research
18. Rapid Modulation of Subcallosal Cingulate Activity and Depression Using Ultrasonic Arrays
Excessive activity of the subcallosal cingulate (SCC) has been linked to depression. Direct and selective engagement of deep brain regions like the SCC is currently only possible with invasive surgical approaches. We have addressed this limitation by creating a new, non-significant-risk, MRI-compatible device that uses two opposing ultrasonic arrays to measure and accurately compensate for attenuation and distortion caused by the head, enabling precise delivery of ultrasound to deep brain regions at known intensity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Brian Mickey, Thomas Riis, Daniel Feldman, Sarah Kwon, Lily Vonesh, Jefferson Brown, Daniela Solzbacher, Jan Kubanek Source Type: research
