Elucidating the influence of familial interactions on geriatric depression: A comprehensive nationwide multi-center investigation leveraging machine learning
CONCLUSION: Prolonging the duration of nocturnal sleep, and elevating the frequency of communication with offspring have been identified as measures conducive to mitigating the onset of geriatric depression.PMID:38631151 | DOI:10.1016/j.actpsy.2024.104274 (Source: Acta Psychologica)
Source: Acta Psychologica - April 17, 2024 Category: Psychiatry & Psychology Authors: Boyang Sheng Shina Zhang Yuan Gao Shuaishuai Xia Yong Zhu Junfeng Yan Source Type: research
Partial mGlu < sub > 5 < /sub > receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice
CONCLUSION: Partial mGlu5 receptor NAM, M-5MPEP, induced rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhanced (R)-ketamine action in mice, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression as RAAD.PMID:38632187 | DOI:10.1007/s43440-024-00588-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Agnieszka Pa łucha-Poniewiera Anna Rafa ło-Ulińska Michal Santocki Yana Babii Katarzyna Kaczorowska Source Type: research
Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study
Aging Clin Exp Res. 2024 Apr 17;36(1):95. doi: 10.1007/s40520-024-02744-4.ABSTRACTCurrent drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (...
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Giovanna Furneri Simone Varrasi Claudia Savia Guerrera Giuseppe Alessio Platania Vittoria Torre Francesco Maria Boccaccio Maria Federica Testa Federica Martelli Alessandra Privitera Grazia Razza Mario Santagati Santo Di Nuovo Concetta Pirrone Sabrina Cast Source Type: research
Predicting the efficacy of donepezil intervention in Alzheimer's disease patients using regional homogeneity in the inferior orbitofrontal cortex
CONCLUSIONS: These findings deepen our understanding of the brain mechanisms underlying the clinical efficacy of donepezil in AD patients, and provide a novel way to predict its clinical efficacy in such patients.PMID:38630202 | DOI:10.1007/s40520-023-02691-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 17, 2024 Category: Geriatrics Authors: Min Dai Zhongwei Guo Honglian Xia Hong Zhu Jiapeng Li Hongtao Hou Guizhi Zhao Xiaozheng Liu Source Type: research
A hematoma in the anterior abdominal muscle in a woman receiving venlafaxine. A literature review of the reports on similar cases
CONCLUSION: Given the cases of either reductions in the platelet count or impairment of platelet activity accompanied by bleeding events, every clinician should be aware of these possible adverse effects when prescribing SNRIs.PMID:38631301 | DOI:10.1159/000538652 (Source: Acta Haematologica)
Source: Acta Haematologica - April 17, 2024 Category: Hematology Authors: Chrysoula Boutari Evangelia Zarkada Athanasios Vyzantiadis Efthymia Vlachaki Genovefa Mantzou Cristine Karipidou Stamatia Theodoridou Source Type: research
Jiawei Dachaihu decoction protects against mitochondrial dysfunction in atherosclerosis (AS) mice with chronic unpredictable mild stress (CUMS) via SIRT1/PGC-1alpha/TFAM/LON signaling pathway
CONCLUSION: Jiawei Dachaihu extract could alleviate AS and reduce CUMS by upregulating the SIRT1/PGC-1α signaling and promoted its crosstalk with Lon protein to maintain mitochondrial stability.PMID:38631487 | DOI:10.1016/j.jep.2024.118150 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Haijiao Shi Miao Sun Shuai Wang Fanyu He Ronglai Yang Zheng Li Wei Chen Fengrong Wang Source Type: research
Effect of a Single-Session Mindfulness-Based Swinging Technique (MBST) Intervention on Emotional Distress in Cancer Patients Undergoing PET-CT Scan: A Randomized Controlled Trial
Conclusion: The findings suggest the potential role of MBST intervention in mitigating emotional distress in patients undergoing complex diagnostic imaging procedures. Integrating this with conventional care in nuclear medicine settings can provide patient-centered care that addresses their unmet requirements. There is a need for further validation with a larger sample size. Clinical Trial Registration Number: CTRI/2023/04/051243 (Registered prospectively on 03/04/2023).PMID:38629890 | DOI:10.1089/jicm.2023.0488 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Anjali Mangesh Joshi Sonal Sakhale Suchitra Ajay Mehta Santoshi Wadhwani Source Type: research
The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial
CONCLUSIONS: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.FUNDING: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) an...
Source: Psychological Medicine - April 17, 2024 Category: Psychiatry Authors: Jolanda Malamud Gemma Lewis Michael Moutoussis Larisa Duffy Jessica Bone Ramya Srinivasan Glyn Lewis Quentin J M Huys Source Type: research
The interplay between emotional and breastfeeding difficulties in first-time mothers
CONCLUSION: Breastfeeding difficulties and social support are associated with fewer mental health symptoms and higher parental self-efficacy during early postpartum in first-time mothers.PMID:38627925 | DOI:10.1080/02646838.2024.2342893 (Source: Journal of Reproductive and Infant Psychology)
Source: Journal of Reproductive and Infant Psychology - April 17, 2024 Category: Psychiatry & Psychology Authors: Mar ía Ignacia García Soledad Coo Ver ónica Valdés Source Type: research
The Prevalence and Patterns of Maltreatment, Childhood Adversity, and Mental Health Disorders in an Australian Out-Of-Home Care Sample
This study aimed to explore key characteristics of the out-of-home care subgroup of a nationally representative Australian sample. To ensure that mental health services are appropriately targeted, it is critical that we understand the differential impacts of childhood experiences for this cohort. Using the Australian Child Maltreatment Study (N = 8503), we explored patterns of childhood maltreatment and adversity of participants who reported ever being placed in out-of-home care, such as foster care or kinship care. In addition, the prevalence of current and lifetime diagnosis of four mental health disorders were explored....
Source: Child Maltreatment - April 17, 2024 Category: Child Development Authors: Lottie G Harris Daryl J Higgins Megan L Willis David Lawrence Ben Mathews Hannah J Thomas Eva Malacova Rosana Pacella James G Scott David Finkelhor Franziska Meinck Holly E Erskine Divna M Haslam Source Type: research
Psychometric properties of the Turkish reduced morningness and eveningness questionnaire
Chronobiol Int. 2024 Apr 17:1-15. doi: 10.1080/07420528.2024.2339964. Online ahead of print.ABSTRACTThe aim of this study was to examine the psychometric properties of the 5-item Turkish Reduced Morningness-Eveningness Questionnaire (rMEQ) for the first time. The study involved 875 university students in an adaptation and validation study. Participants completed the rMEQ, MEQ, Depression Anxiety Stress Scale-21 (DASS-21), Insomnia Severity Index (ISI), Barratt Impulsiveness Scale Short Form (BIS-SF), and Oxford Happiness Questionnaire Short Form (OHQ-SF). The factor structure, convergent validity, internal consistency, sen...
Source: Chronobiology International - April 17, 2024 Category: Biology Authors: Hilal Uygur Rukiye Tekdemir Omer Faruk Uygur Esat Fahri Aydin Merve Celik Hakan Emre Babacan Onur Hursitoglu Source Type: research
GSE263711 Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysis (ATAC-Seq)
In this study, we characterize the biological pathways that are activated in this in vitro circadian model, evaluating the relevance of these processes in the context of the genetic architecture of BD and other disorders, highlighting its limitations and future applications for circadian genomic studies (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE263713 Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysis (RNA-Seq)
In this study, we characterize the biological pathways that are activated in this in vitro circadian model, evaluating the relevance of these processes in the context of the genetic architecture of BD and other disorders, highlighting its limitations and future applications for circadian genomic studies (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Potential of niacin skin flush response in adolescent depression identification and severity assessment: a case-control study
This study investigates the potential of Niacin Skin Flush Response (NSFR) as a biomarker for iden... (Source: BMC Psychiatry)
Source: BMC Psychiatry - April 17, 2024 Category: Psychiatry Authors: Jie Feng, Wenjiao Min, Dandan Wang, Jing Yuan, Junming Chen, Lisha Chen, Wei Chen, Meng Zhao, Jia Cheng, Chunling Wan, Bo Zhou, Yulan Huang and Yaoyin Zhang Tags: Research Source Type: research
Study protocol: exercise training for treating major depressive disorder in multiple sclerosis
Major depressive disorder (MDD) is prevalent, yet sub-optimally treated among persons with multiple sclerosis (MS). We propose that exercise training may be a promising approach for treating depression in pers... (Source: BMC Neurology)
Source: BMC Neurology - April 17, 2024 Category: Neurology Authors: Robert W. Motl, Charles H. Bombardier, Jennifer Duffecy, Brooks Hibner, Alison Wathen, Michael Carrithers and Gary Cutter Tags: Study Protocol Source Type: research
