[Report] Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E
Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E–restricted presentation of highly varied peptide epitopes to CD8αβ+ T cells, at ~4 distinct epitopes per 100 amino acids in all tested antigens. Computational structural analysis revealed that MHC-E provides heterogeneous chemical environments for diverse si...
Source: ScienceNOW - February 12, 2016 Category: Science Authors: Scott G. Hansen Source Type: news
The Latest On Zika: New Countries Are Added To The CDC's Watch List
On Monday the U.S. Centers for Disease Control and Prevention added four countries and territories to its growing list of places with active Zika virus transmissions, which means that the cases occurred locally, rather than in travelers returning from a place where they acquired the virus. So far, no local cases of Zika have been reported in the United States. The virus, which is spread by the Aedes aegypti mosquito, is strongly suspected to be linked to a new wave of microcephaly cases in Brazil. Babies born with the birth defect have smaller heads and brains that aren't fully developed, which can result in lif...
Source: Healthy Living - The Huffington Post - February 2, 2016 Category: Consumer Health News Source Type: news
Brazil Wages War against Zika Virus on Several Fronts
In the country’s capital, Brazilian President Dilma Rousseff oversees one of the military operations against the Aedes Aegypti mosquito carried out at a national level in the last few days to curb the spread of the Zika virus. Credit: Roberto Stuckert Filho/PRBy Mario OsavaRIO DE JANEIRO, Feb 2 2016 (IPS)Brazil is deploying 220,000 troops to wage war against the Zika virus, in response to the alarm caused by the birth of thousands of children with abnormally small heads. But eradicating the Aedes aegypti mosquito requires battles on many fronts, including science and the pharmaceutical industry.The Zika virus, transmitte...
Source: IPS Inter Press Service - Health - February 2, 2016 Category: Global & Universal Authors: Mario Osava Tags: Development & Aid Editors' Choice Featured Headlines Health Latin America & the Caribbean Population Poverty & SDGs Regional Categories TerraViva United Nations Brazil cities Science and Technology Zika Virus Source Type: news
Q&A: Zika virus in mothers linked with microcephaly in babies in Brazil
You may have heard the news: Brazil is facing a startling outbreak of microcephaly, a rare condition in which an infant is born with a head much smaller than it should be. Microcephaly almost always causes significant brain damage and can be life threatening. The epidemic has been linked to a simultaneous influx of the mosquito-borne virus Zika.
Thriving spoke with Dr. Ganeshwaran Mochida, a pediatric neurologist at Boston Children’s Hospital who specializes in microcephaly, and Dr. Asim Ahmed, an infectious disease researcher at Boston Children’s who specializes in mosquito-borne illnesses, to find out more about the...
Source: Thrive, Children's Hospital Boston - January 11, 2016 Category: Pediatrics Authors: Erin Horan Tags: Ask the Expert Diseases & Conditions Health Headlines In the News dr. asim ahmed dr. ganesh mochida http://www.childrenshospital.org/conditions-and-treatments/conditions/cytomegalovirus/overview infectious diseases microcephaly mosquitoe Source Type: news
Chimerix Antiviral Drug Fails in Late-Stage StudyChimerix Antiviral Drug Fails in Late-Stage Study
Chimerix Inc said its oral antiviral drug brincidofovir did not significantly reduce cytomegalovirus (CMV) infection through week 24 after hematopoietic stem cell transplant in a late-stage study, sending its shares down 72% in premarket trading Monday. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 29, 2015 Category: Pathology Tags: Infectious Diseases News Source Type: news
Chimerix Announces Top-Line Results From Phase 3 SUPPRESS Trial of Brincidofovir
SUPPRESS Did Not Achieve Primary Endpoint for Prevention of Clinically Significant CMV Infection After HCT
Detailed Data Analysis to Follow
Company to Hold Conference Call Today at 8:30 a.m. ET
DURHAM, N.C., Dec. 28, 2015 -- (Healthcare Sales & Ma... BiopharmaceuticalsChimerix, brincidofovir, cytomegalovirus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 28, 2015 Category: Pharmaceuticals Source Type: news
Atara Bio Announces Positive Results From a Phase 2 Clinical Trial of Cytomegalovirus Targeted Cytotoxic T Lymphocytes (CMV-CTL), a Novel Approach to Adoptive Immunotherapy, to Treat Patients With Refractory CMV Disease in the Central Nervous System (CNS)
(Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - December 6, 2015 Category: Pharmaceuticals Source Type: news
How cells are foiled by a herpesvirus family member in the virus-host arms race
Not every virus wants to go viral right away -- some want to wait for the perfect opportunity to attack. So the virus has to find a way to enter the cells of the human body without tripping the alarm. It's how viruses in the herpesvirus family, like human cytomegalovirus (HCMV), do their business. In a new study, researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 4, 2015 Category: Science Source Type: news
How cells are foiled by a herpesvirus family member in the virus-host arms race
(University of Wisconsin-Madison) Not every virus wants to go viral right away -- some want to wait for the perfect opportunity to attack. So the virus has to find a way to enter the cells of the human body without tripping the alarm. It's how viruses in the herpesvirus family, like human cytomegalovirus (HCMV), do their business. In a new study published in Science Advances, researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 4, 2015 Category: Global & Universal Source Type: news
How Activists Changed The Federal Approach To AIDS Research Forever
When Dr. Anthony Fauci first became director of the National Institute of Allergies and Infectious Diseases in 1984, hundreds of people in the U.S. had already died from a mysterious and terrifying disease we now know to be HIV/AIDS. But even though the NIAID was in charge of finding treatments, vaccines and cures for communicable diseases, Fauci said his agency failed to act quickly enough in its search for effective medicines. The traditional research-to-pharmaceutical pipeline, of which Fauci remained staunchly in favor until a dramatic change of heart, took several years from start to finish -- and people with HIV...
Source: Healthy Living - The Huffington Post - December 1, 2015 Category: Consumer Health News Source Type: news
Transplant tourism increases health-related risks for organ recipients
Compared with recipients of living related kidney donor transplants, recipients who purchased organs internationally were more likely to develop hepatitis C, hepatitis B, and cytomegalovirus, and they were more likely to experience acute and recurrent rejections and surgical complications. Patient and organ survival rates were also lower in 'commercial' recipients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 6, 2015 Category: Science Source Type: news
Updates to the CMV (Herpes Virus) Section of the Adult OI Guidelines
This revision provides guidance for the management of cytomegalovirus (CMV) retinitis, which develops or worsens in the setting of ART initiation. Data supporting the treatment of CMV retinitis with systemic anti-CMV therapy for prevention of contralateral eye and visceral disease are discussed.
(Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - November 6, 2015 Category: Infectious Diseases Source Type: news
Monkey model discovery could spur CMV vaccine development
Rhesus monkeys can, in fact, transmit Cytomegalovirus (CMV) across the placenta to their unborn offspring, new research shows. This finding establishes the first primate model that researchers can use to study mother-to-fetus CMV infections and spur development of potential vaccine approaches. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 19, 2015 Category: Science Source Type: news
Monkey model discovery could spur CMV vaccine development
(Duke University Medical Center) Researchers at Duke Medicine have discovered that rhesus monkeys can, in fact, transmit cytomegalovirus across the placenta to their unborn offspring. This finding, reported online during the week of Oct. 19 in the Proceedings of the National Academy of Sciences, establishes the first primate model that researchers can use to study mother-to-fetus CMV infections and spur development of potential vaccine approaches. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 19, 2015 Category: Infectious Diseases Source Type: news
Self-injurious behavior secondary to cytomegalovirus-induced neuropathy in an SIV-Infected Rhesus Macaque (Macaca mulatta) - Clemmons EA, Gumber S, Strobert E, Bloomsmith MA, Jean SM.
A 3.5-y-old, female rhesus macaque (Macaca mulatta) inoculated with SIVmac239 presented 8 mo later for inappetence and facial bruising. Physical examination revealed a superficial skin abrasion below the left eye, bruising below the left brow, and epistaxi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 12, 2015 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
