Janssen to Highlight Science, Innovation and Advances in Robust Oncology Portfolio and Pipeline Through More Than 60 Data Presentations at ASCO and EHA
RARITAN, N.J., May 31, 2022 — The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that new research and data from its robust oncology portfolio and pipeline of investigational therapies will be presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 3-7 in Chicago, and the European Hematology Association (EHA) 2022 Congress taking place in Vienna, Austria, June 9-12. More than 60 presentations from company-sponsored studies across the two congresses, including 14 oral presentations, will feature new data and updates for both approved and investigation...
Source: Johnson and Johnson - May 31, 2022 Category: Pharmaceuticals Source Type: news
Man given a PIG's heart in world-first transplant may have died as the organ was infected
DAVID BENNETT was the first person in the world to receive a pig's heart transplant. Sadly, the 57-year-old died on March 8 merely MONTHS after the surgery. An expert now thinks that the transplant might have been infected with porcine cytomegalovirus. (Source: Daily Express - Health)
Source: Daily Express - Health - May 6, 2022 Category: Consumer Health News Source Type: news
Signs of an Animal Virus Discovered in Man Who Received a Pig ’s Heart
The patient showed no sign of rejecting the genetically modified organ, but suffered numerous complications before dying. (Source: NYT Health)
Source: NYT Health - May 6, 2022 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Transplants Surgery and Surgeons Pigs Genetic Engineering Cytomegalovirus University of Maryland Source Type: news
An Animal Virus Infected the Man Who Received a Pig ’s Heart
The patient showed no sign of rejecting the genetically modified organ, but may have died from the viral infection, his surgeon said. (Source: NYT Health)
Source: NYT Health - May 5, 2022 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Transplants Surgery and Surgeons Pigs Genetic Engineering Cytomegalovirus University of Maryland Source Type: news
U.S. FDA Approves CARVYKTI ™ (ciltacabtagene autoleucel), Janssen’s First Cell Therapy, a BCMA-Directed CAR-T Immunotherapy for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., February 28, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) has approved CARVYKTI™ (ciltacabtagene autoleucel; cilta-cel) for the treatment of adults with relapsed or refractory multiple myeloma (RRMM) after four or more prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.1 The approval is based on data from the pivotal CARTITUDE-1 study, which included patients who had received a median of six prior treatment regimens (range, 3-18), and had previously rec...
Source: Johnson and Johnson - March 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
What Causes Rectal Prolapse?
Discussion
Rectal prolapse is defined as a herniation of the rectum through the anal verge. In children it is also usually mucosal prolapse and not full thickness. Partial or mucosal prolapse usually is seen as radial folds occurring 1 – 2.5 cm from the anal verge. Full thickness will protrude more than 5 cm. It affects genders equally and occurs most commonly in children under age 4. This is due to vertical course and low position of the anus, looser supporting tissues and less muscular support. These children are more likely to have prolapse but are less likely to have it recur. After age 4 the rectum takes the adu...
Source: PediatricEducation.org - February 28, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
FDA Approves First Drug for Treatment of Resistant CMV FDA Approves First Drug for Treatment of Resistant CMV
Transplant patients are particularly vulnerable to cytomegalovirus (CMV) infection, which can lead to organ loss or death.FDA Approvals (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - November 24, 2021 Category: Infectious Diseases Tags: Transplantation News Alert Source Type: news
FDA Approves Livtencity (maribavir) for Post-Transplant Cytomegalovirus (CMV) Infection/Disease
- In the Phase 3 SOLSTICE study, more than twice the proportion of adult transplant recipients with refractory or resistant (R/R) CMV infection/disease achieved confirmed CMV DNA level<LLOQ at Week 8 with Livtencity (56%; n=131/235), compared to... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - November 23, 2021 Category: Drugs & Pharmacology Source Type: news
FDA Approves First Treatment for Common Type of Post-Transplant Infection that is Resistant to Other Drugs
The FDA approved the first drug for treating adults and pediatric patients with post-transplant cytomegalovirus infection/disease that does not respond (with or without genetic mutations that cause resistance) to available antiviral treatment for cytomegalovirus. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - November 23, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news
What Are the Advantages and Disadvantages of Different Renal Replacement Therapies?
Discussion
Kidneys are amazing in that they filter the blood, eliminate toxins, balance fluids and electrolytes plus have a lot of reserve to do the job they need to do even when injured. Therefore, depending on the problem, chronic renal disease (CRD) often allows time before renal replacement therapy (RRT) is needed. RRT currently is dialysis (peritoneal or hemodialysis) or renal transplant. In general, the patient’s own kidneys do the best job for them but there is always a balance between the problems of CRD and its management, versus the potentially improved renal function with RRT. RRT itself though has a diffe...
Source: PediatricEducation.org - September 13, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Hyperimmune Globulin Does Not Prevent Congenital CMV Infection
FRIDAY, July 30, 2021 -- Administration of cytomegalovirus (CMV) hyperimmune globulin versus placebo to women with primary CMV infection in early pregnancy does not result in a lower incidence of congenital CMV infection or perinatal death in their... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 30, 2021 Category: Pharmaceuticals Source Type: news
Antiviral May Improve Hearing Loss in Congenital CMV Antiviral May Improve Hearing Loss in Congenital CMV
A new study found that infants with isolated sensorineural hearing loss as a result of congenital cytomegalovirus infection may benefit from treatment with valganciclovir.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - June 2, 2021 Category: Drugs & Pharmacology Tags: Pediatrics News Source Type: news
How a common, often harmless virus called cytomegalovirus can damage a fetus
Pregnant women are rarely warned by their doctors about CMV, which can cause premature birth, hearing loss, vision problems and developmental delays. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - May 15, 2021 Category: Consumer Health News Authors: Marlene Cimons Source Type: news
Scientists launch a pre-emptive strike on deadly post-transplant infection
(University of Cambridge) A potential new treatment to protect immunosuppressed patients from human cytomegalovirus (HCMV) has been discovered by scientists at the University of Cambridge. Their study shows that certain epigenetic inhibitors expose and help to destroy dormant HCMV infections, which often reactivate to cause serious illness and death in these vulnerable groups. Subject to clinical trials, their proposed 'shock and kill' treatment strategy offers hope to transplant patients across the world. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 22, 2021 Category: Infectious Diseases Source Type: news
What is a Lipschultz Ulcer?
Discussion
Acute genital ulcers (AGU) are much less common in sexually-naive women than sexually experienced or active women. The differential diagnosis of AGU is large. For sexually active women Herpes simplex virus is the most common cause. Sexually transmitted infections are also included in this differential. In addition to the pain, AGUs can cause distress for the patient and family as possible sexual abuse must be considered.
The differential diagnosis of AGU in non-sexually active women includes:
Aphthosis
Lipschutz ulcer
Idiopathic
Autoimmune or inflammatory diseases
Behcet disease
Bullous pemphigoid
Inflammato...
Source: PediatricEducation.org - February 8, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
