Disrupted immunity in fetal brain is linked to neurodevelopmental disorders
New research findings in mice may help explain how viral infection during pregnancy raises the risk of autism and schizophrenia in their offspring. The study may explain, among other things, how the mother's infection with the cytomegalovirus (CMV) during pregnancy, which affects her own and her fetus's immune system, increases the risk that her offspring will develop autism or schizophrenia, sometimes years later. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 27, 2016 Category: Science Source Type: news

Teaching an old drug new tricks to fight cytomegalovirus
(Johns Hopkins Medicine) Researchers at Johns Hopkins have found that an old drug once mostly used to treat amebiasis -- a disease caused by a parasite -- and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus that can cause serious disease in immunocompromised individuals, including those with HIV or organ transplant recipients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 27, 2016 Category: Global & Universal Source Type: news

Roche announces the first FDA-approved CMV test for use in hematopoietic stem cell transplant recipients
New test standardizes CMV testing for both solid organ and hematopoietic stem cell transplant recipients PLEASANTON, Calif., May 25, 2016 -- (Healthcare Sales & Marketing Network) -- Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the United States ... Diagnostics, FDARoche, Roche Group, cytomegalovirus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 25, 2016 Category: Pharmaceuticals Source Type: news

Vaccine Boosts Glioblastoma SurvivalVaccine Boosts Glioblastoma Survival
A novel combination of cytomegalovirus-targeted dendritic cell vaccine and tetanus preconditioning shows a significant increase in survival and improved immune response in glioblastoma. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 12, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

What viruses do to neuronal stem cells -- effects of congenital transmission
(PLOS) Congenital transmission (from mother to unborn child) of viruses can cause abnormal brain development in the fetus. Examples of viruses that can pass through the placenta and into the fetal brain include cytomegalovirus, rubella, and zika virus. A study published on April 14th in PLOS Pathogens examines the effects of human cytomegalovirus (HCMV) infection on neuronal stem cells and reports that the virus delays or prevents proper differentiation of the stem cells into mature brain cells by activating a key signaling pathway. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 14, 2016 Category: Infectious Diseases Source Type: news

Analytic Vaccinology: Antibody-Driven Design of a Human Cytomegalovirus Subunit Vaccine
Identification of the most relevant protective antigens has represented a considerable obstacle for the development of subunit vaccines against viral infections, including human cytomegalovirus (HCMV) infection. This chapter describes the method of analytic vaccinology, centered on the clonal analysis of human B cell response to HCMV, which represents an essential tool for assessing the impact of individual viral antigens in the antiviral antibody response. By providing key information on the immunogenicity and protective properties of the antibodies elicited by viral proteins, the analytic vaccinology method guides the se...
Source: Springer protocols feed by Immunology - April 8, 2016 Category: Allergy & Immunology Source Type: news

What Genetics are Associated with Multiple Sclerosis?
Discussion Multiple sclerosis (MS) is “a chronic degenerative, often episodic disease of the central nervous system marked by patchy destruction of the myelin that surrounds and insulates nerve fibers, usually appearing in young adulthood and manifested by one or more mild to severe neural and muscular impairments, as spastic weakness in one or more limbs, local sensory losses, bladder dysfunction, or visual disturbances.” It is a chronic disease and therefore symptoms must occur more than once. The first episode is called an acute demyelinating attack. Fifteen to forty-five percent of children with their first...
Source: PediatricEducation.org - April 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Threat of cytomegalovirus far outweighs Zika risk, researcher says
Researcher studies the impact of CMV on healthcare providers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 15, 2016 Category: Science Source Type: news

New study highlights effectiveness of a herpesvirus CMV-based vaccine against Ebola
(University of Plymouth) As the latest in a series of studies, researchers have shown the ability of a vaccine vector based on a common herpesvirus called cytomegalovirus (CMV) expressing Ebola virus glycoprotein (GP), to provide protection against Ebola virus in the experimental rhesus macaque, non-human primate (NHP) model. Demonstration of protection in the NHP model is regarded as a critical step before translation of Ebola virus vaccines into humans and other great apes. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 15, 2016 Category: Infectious Diseases Source Type: news

[Report] Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E
Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E–restricted presentation of highly varied peptide epitopes to CD8αβ+ T cells, at ~4 distinct epitopes per 100 amino acids in all tested antigens. Computational structural analysis revealed that MHC-E provides heterogeneous chemical environments for diverse si...
Source: ScienceNOW - February 12, 2016 Category: Science Authors: Scott G. Hansen Source Type: news

The Latest On Zika: New Countries Are Added To The CDC's Watch List
On Monday the U.S. Centers for Disease Control and Prevention added four countries and territories to its growing list of places with active Zika virus transmissions, which means that the cases occurred locally, rather than in travelers returning from a place where they acquired the virus. So far, no local cases of Zika have been reported in the United States.  The virus, which is spread by the Aedes aegypti mosquito, is strongly suspected to be linked to a new wave of microcephaly cases in Brazil. Babies born with the birth defect have smaller heads and brains that aren't fully developed, which can result in lif...
Source: Healthy Living - The Huffington Post - February 2, 2016 Category: Consumer Health News Source Type: news

Brazil Wages War against Zika Virus on Several Fronts
In the country’s capital, Brazilian President Dilma Rousseff oversees one of the military operations against the Aedes Aegypti mosquito carried out at a national level in the last few days to curb the spread of the Zika virus. Credit: Roberto Stuckert Filho/PRBy Mario OsavaRIO DE JANEIRO, Feb 2 2016 (IPS)Brazil is deploying 220,000 troops to wage war against the Zika virus, in response to the alarm caused by the birth of thousands of children with abnormally small heads. But eradicating the Aedes aegypti mosquito requires battles on many fronts, including science and the pharmaceutical industry.The Zika virus, transmitte...
Source: IPS Inter Press Service - Health - February 2, 2016 Category: Global & Universal Authors: Mario Osava Tags: Development & Aid Editors' Choice Featured Headlines Health Latin America & the Caribbean Population Poverty & SDGs Regional Categories TerraViva United Nations Brazil cities Science and Technology Zika Virus Source Type: news

Q&A: Zika virus in mothers linked with microcephaly in babies in Brazil
You may have heard the news: Brazil is facing a startling outbreak of microcephaly, a rare condition in which an infant is born with a head much smaller than it should be. Microcephaly almost always causes significant brain damage and can be life threatening. The epidemic has been linked to a simultaneous influx of the mosquito-borne virus Zika. Thriving spoke with Dr. Ganeshwaran Mochida, a pediatric neurologist at Boston Children’s Hospital who specializes in microcephaly, and Dr. Asim Ahmed, an infectious disease researcher at Boston Children’s who specializes in mosquito-borne illnesses, to find out more about the...
Source: Thrive, Children's Hospital Boston - January 11, 2016 Category: Pediatrics Authors: Erin Horan Tags: Ask the Expert Diseases & Conditions Health Headlines In the News dr. asim ahmed dr. ganesh mochida http://www.childrenshospital.org/conditions-and-treatments/conditions/cytomegalovirus/overview infectious diseases microcephaly mosquitoe Source Type: news

Chimerix Antiviral Drug Fails in Late-Stage StudyChimerix Antiviral Drug Fails in Late-Stage Study
Chimerix Inc said its oral antiviral drug brincidofovir did not significantly reduce cytomegalovirus (CMV) infection through week 24 after hematopoietic stem cell transplant in a late-stage study, sending its shares down 72% in premarket trading Monday. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 29, 2015 Category: Pathology Tags: Infectious Diseases News Source Type: news