AiCuris and Merck Announce Publication in New England Journal of Medicine of Phase 2 Clinical Trial Results of Investigational Antiviral Agent Letermovir in Bone Marrow Transplant Patients
Dateline City:
WUPPERTAL, Germany & WHITEHOUSE STATION, N.J.
WUPPERTAL, Germany & WHITEHOUSE STATION, N.J.--(BUSINESS WIRE)--AiCuris and Merck (NYSE:MRK), known as MSD outside the United States and
Canada, today announced the publication of results from a Phase 2
clinical trial evaluating the safety and efficacy of letermovir, an
investigational, oral antiviral agent for the prevention of human
cytomegalovirus (CMV) infection in patients receiving bone marrow
transplant.
Language:
English ...
Source: Merck.com - Research and Development News - May 8, 2014 Category: Pharmaceuticals Tags: Research and Development News Corporate News Latest News Source Type: news
What is in the Differential Diagnosis of Purpura?
Discussion
Children presenting with rashes are common but certain characteristics may be concerning such as descriptions of petechiae or purpura. Purpura are characterized by non-blanching skin lesions between 3-10 mm in size that are caused by bleeding into the skin. Usually they are reddish-purplish hence the name purpura coming from the Latin word. Non-blanching lesions that are 10 mm are ecchymosis.
Henoch-Schönlein purpura (HSP) is a generalized vasculitis that commonly involves the gastrointestinal tract, kidneys, skin and joints, and is especially seen in children 2-11 years old. Classically HSP presents with ...
Source: PediatricEducation.org - May 5, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Human Cytomegalovirus Blocks Erythropoietin Synthesis in CKDHuman Cytomegalovirus Blocks Erythropoietin Synthesis in CKD
Kidneys from patients with CKD were positive for human cytomegalovirus protein (hCMV), and high blood levels of hCMV immunoglobulin G were associated with anemia, a study has shown. Medscape Medical News (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - April 16, 2014 Category: Urology & Nephrology Tags: Nephrology News Source Type: news
Common virus may cause anemia in patients with kidney disease
Kidneys from most patients with chronic kidney disease in a new study were positive for active cytomegalovirus infection. Patients with higher levels of anti-cytomegalovirus antibodies in their blood had lower number of red blood cells. Cytomegalovirus blocks a protein needed to make a hormone that in turn stimulates red blood cell production. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 10, 2014 Category: Science Source Type: news
Featured in NEJM Journal Watch: Prevention of Congenital Cytomegalovirus Infection (FREE)
By the NEJM Journal Watch Editors, The
Hyperimmune … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 3, 2014 Category: Primary Care Source Type: news
Researchers Identify Protein That Helps Control Common Viral Infection - 3/27/14
Infectious disease specialists at the Johns Hopkins Children’s Center have identified a protein that regulates the body’s immune response to cytomegalovirus (CMV), a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune systems. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - March 27, 2014 Category: Research Source Type: news
Researchers identify protein that helps control common viral infection
(Johns Hopkins Medicine) Infectious disease specialists at the Johns Hopkins Children's Center have identified a protein that regulates the body's immune response to cytomegalovirus, a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune systems. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 26, 2014 Category: Infectious Diseases Source Type: news
CMV (Cytomegalovirus): Not Just Life Threatening to Babies; CBCD...
The Cytomegalovirus killed the baby of a family from Houston, Texas according to an article published on the website of the NBC affiliate news website, ketknbc.com on March 1, 2014 (1). The Center for...(PRWeb March 21, 2014)Read the full story at http://www.prweb.com/releases/2014/03/prweb11684544.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 21, 2014 Category: Pharmaceuticals Source Type: news
Seeking out the hiding place of a virus could lead to new treatments
Discovering where a common virus hides in the body has been a long-term quest for scientists. Up to 80 percent of adults harbor the human cytomegalovirus (HCMV), which can cause severe illness and death in people with weakened immune systems.Now, researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine report that stem cells that encircle blood vessels can be a hiding place, suggesting a potential treatment target.In the American Journal of Transplantation (online ahead of print), senior scientist Graca Almeida-Porada, M.D., Ph.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 13, 2014 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Finding hiding place of virus could lead to new treatments
(Wake Forest Baptist Medical Center) Discovering where a common virus hides in the body has been a long-term quest for scientists. Up to 80 percent of adults harbor the human cytomegalovirus, which can cause severe illness and death in people with weakened immune systems. Now, researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine report that stem cells that encircle blood vessels can be a hiding place, suggesting a potential treatment target. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 11, 2014 Category: Global & Universal Source Type: news
Cytomegalovirus (CMV)
Title: Cytomegalovirus (CMV)Category: Diseases and ConditionsCreated: 11/7/2000 12:00:00 AMLast Editorial Review: 2/11/2014 12:00:00 AM (Source: MedicineNet HIV General)
Source: MedicineNet HIV General - February 11, 2014 Category: Infectious Diseases Source Type: news
The boy who can't go near pregnant women: Teenager has contagious virus that can cause disabilities in unborn babies
Bryant Hackett, 14, from Sunderland, has cytomegalovirus which is usually harmless for adults but can cause deafness and learning disabilities in unborn babies. (Source: the Mail online | Health)
Source: the Mail online | Health - January 31, 2014 Category: Consumer Health News Source Type: news
Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors
During coevolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7 transmembrane spanning (7TM) G protein-coupled receptors (GPCRs). These include virus-encoded GPCRs and ligands and viral regulation of endogenous GPCRs. Many functional properties have been ascribed to virus-exploited GPCRs, and although the list of putative functions is steadily growing, the presence and/or function of virus-associated GPCRs is still poorly understood. This review focuses on three well-described functional properties of virus-associated GPCRs: (1) the immune evasion strategies, exemplifi...
Source: Springer protocols feed by Pharmacology/Toxicology - January 27, 2014 Category: Drugs & Pharmacology Source Type: news
CMV Infection Tied to Response to Arthritis Tx (CME/CE)
(MedPage Today) -- A specific immune response signature associated with latent cytomegalovirus (CMV) infection may help predict response to treatment in very early rheumatoid arthritis, researchers reported. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - November 26, 2013 Category: Geriatrics Source Type: news
CMV rapidly evolves as it spreads from mother to fetus, providing genetic targets for new therapeutics
New insights into how human cytomegalovirus (CMV), the leading cause of birth defects associated with infection spreads from pregnant mother to fetus and from organ to organ in newborns provides translational researchers an exciting new avenue for investigation that may lead to the development of therapeutic interventions. Using next generation sequencing and population genetic modeling, scientists at the University of Massachusetts Medical School (UMMS) and the Ecole Polytechnique Fédérale de Lausanne (EPFL) have found that CMV evolves rapidly and dramatically in humans... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news
