New Antiviral Option for CMV Prophylaxis After Kidney Transplant
(MedPage Today) -- Letermovir (Prevymis) proved noninferior to valganciclovir (Valcyte), the standard of care, in a clinical trial of cytomegalovirus (CMV) prophylaxis in high-risk kidney transplant patients, researchers reported.
In a phase III... (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - June 7, 2023 Category: Surgery Source Type: news
U.S. FDA Approves New Indication for Merck ’s Prevymis (letermovir) for Prevention of Cytomegalovirus (CMV) Disease in High-Risk Adult Kidney Transplant Recipients
RAHWAY, N.J.--(BUSINESS WIRE) June 6, 2023 -- Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced the U.S. Food and Drug Administration (FDA) has approved a new indication for Prevymis® (letermovir) for... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - June 6, 2023 Category: Drugs & Pharmacology Source Type: news
Janssen to Highlight Scientific Advances and Commitment to Transform Cancer Care at ASCO and EHA with More than 90 Presentations Showcasing Robust, Differentiated Portfolio and Pipeline in Hematologic Malignancies and Solid Tumors
This study evaluates an investigational combination regimen of IMBRUVICA® (ibrutinib) plus venetoclax (I+V) for newly diagnosed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), (Abstracts #7535 and #P617, respectively).Advancing the Science of Solid Tumors Through Precision MedicineJanssen’s continued innovation in solid tumors focuses on advancing precision medicine options for patients with biomarker-driven disease who have limited targeted treatment options and moving patients into earlier lines of therapy when treatments may be more effective. Lung CancerAn oral presentation will report ...
Source: Johnson and Johnson - May 18, 2023 Category: Pharmaceuticals Tags: Innovation Source Type: news
The effects of cytomegalovirus on brain structure following sport-related concussion - Savitz J, Goeckner BD, Ford BN, Teague TK, Zheng H, Harezlak J, Mannix R, Muftuler LT, Brett BL, McCrea MA, Meier TB.
The neurotrophic herpesvirus cytomegalovirus is a known cause of neuropathology in utero and in immunocompromised populations. Cytomegalovirus is reactivated by stress and inflammation, possibly explaining the emerging evidence linking it to subtle brain c... (Source: SafetyLit)
Source: SafetyLit - April 20, 2023 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
What Causes Parotitis?
Discussion
The salivary glands are important for creating saliva which helps with taste, digestion, oral health, and speech. Salivary gland problems are not that common but can be painful, annoying or herald potential systemic diseases. The parotid gland is the largest salivary gland lying anterior to the ear within the cheek structures. There are 2 lobes (superficial and deep) and the facial nerve runs between them. The salivary duct opens adjacent to the upper second molar. Infections are the most common cause of parotitis with mumps being the most commonly associated infection especially in unimmunized patients.
Patient...
Source: PediatricEducation.org - April 10, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Janssen Announces Unblinding of Phase 3 CARTITUDE-4 Study of CARVYKTI ® (cilta-cel) as Primary Endpoint Met in Treatment of Patients with Relapsed and Refractory Multiple Myeloma
RARITAN, New Jersey, January 27, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Phase 3 CARTITUDE-4 study evaluating CARVYKTI® (ciltacabtagene autoleucel; cilta-cel) versus pomalidomide, bortezomib, and dexamethasone (PVd) or daratumumab, pomalidomide, and dexamethasone (DPd) for the treatment of patients with relapsed and lenalidomide-refractory multiple myeloma met its primary endpoint of significant improvement in progression-free survival (PFS) at the first pre-specified interim analysis. As a result of meeting the primary endpoint, the Independent Data Monitoring Commi...
Source: Johnson and Johnson - January 27, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Congenital CMV Linked to Pediatric Hyperdiploid ALL Congenital CMV Linked to Pediatric Hyperdiploid ALL
Early congenital cytomegalovirus could be a modifiable risk factor for childhood hyperdiploid acute lymphoblastic leukemia but more research delineating a mechanism is warranted.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 13, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Factors ID'd for Hearing Loss in Newborns With Congenital Cytomegalovirus
FRIDAY, Dec. 30, 2022 -- Independent risk factors for congenital hearing loss have been identified in newborns with congenital cytomegalovirus (cCMV) infection, according to a study published online Dec. 29 in JAMA Otolaryngology-Head& Neck... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 30, 2022 Category: Pharmaceuticals Source Type: news
What Are the Potential Benefits and Risks of Premasticated Foods?
Discussion
Premastication is the prechewing of foods or medicines by another person before feeding to an infant. It is also used to pretaste or temperature test foods. It was a common practice for millennia, especially before modern food technology, as a way to transition an infant from a solely liquid based diet to a mixed diet mainly of solid food. Rates of premastication vary, with less developed countries having an increased incidence/prevalence (up to 50%) but it is not uncommon in developed countries (in the US 14% is reported).
Saliva is also used to clean other people, treat cuts/itches or insect bites as well. Pla...
Source: PediatricEducation.org - November 14, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Janssen to Highlight Latest Scientific Advances in Hematologic Diseases at ASH 2022 with Clinical and Real-World Data Across Innovative Pipeline and Distinguished Portfolio
RARITAN, N.J., November 3, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson are committed to redefining treatment outcomes in the hematology setting and today announced that abstracts from more than 50 company-sponsored studies, plus more than 20 investigator-initiated studies, will be presented at the American Society of Hematology (ASH) Annual Meeting in New Orleans from December 10-13, 2022. Janssen’s commitment to advancing an innovative portfolio of therapies for healthcare professionals and patients is evidenced through more than 70 presentations that span clinical studies and r...
Source: Johnson and Johnson - November 3, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Cytomegalovirus is a Risk Factor for VTE in ANCA Vasculitis Cytomegalovirus is a Risk Factor for VTE in ANCA Vasculitis
Past exposure to cytomegalovirus has been identified as a risk factor for VTE development in patients with ANCA-associated vasculitis.Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 18, 2022 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
Congenital Cytomegalovirus Declined in Wake of COVID-19 Congenital Cytomegalovirus Declined in Wake of COVID-19
Prevalence for cCMV was highest among newborns of mothers aged 24 and younger, and in non-Hispanic Black mothers.MDedge News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - September 14, 2022 Category: Infectious Diseases Tags: Pediatrics News Source Type: news
What are Potential Problems with Placental Abnormalities?
Discussion
“The placenta is a unique organ that sits at the interface of, and facilitates nearly all interactions between, maternal and fetal physiology. It is the sole source of oxygen and nutrition for the fetus, and provides a protective barrier against external insults. The placenta is also a highly adaptable organ that is capable of showing a wide range of pathological changes in response to various maternal and fetal factors and stressors.” The placenta has 3 layers: the amnion (fetal side), the chorion, and decidua (maternal side). In addition to making observations about the maternal and fetal sides, co...
Source: PediatricEducation.org - June 27, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
CMV Seropositivity Tied to Cortical Surface Area in Schizophrenia
FRIDAY, June 17, 2022 -- For adults with schizophrenia spectrum disorders, previous cytomegalovirus (CMV) infection is associated with smaller total cortical surface area, according to a study recently published in Schizophrenia Bulletin.
Dimitrios... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 17, 2022 Category: Pharmaceuticals Source Type: news
Longer-term Data from CARTITUDE-1 Study Demonstrate Continued Deep and Durable Responses to CARVYKTI ™ (ciltacabtagene autoleucel) in Heavily Pretreated Patients with Relapsed or Refractory Multiple Myeloma
CHICAGO, ILLINOIS, June 4, 2022 – – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today updated results from the Phase 1b/2 CARTITUDE-1 study evaluating the efficacy and safety of CARVYKTI™ (ciltacabtagene autoleucel; cilta-cel), a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy. The study included patients with relapsed or refractory multiple myeloma (RRMM) who had received >3 lines of therapy including a proteasome inhibitor (PI), an anti-CD38 monoclonal antibody and an immunomodulatory agent (IMiD) or were double refractory to an IMiD and PI a...
Source: Johnson and Johnson - June 4, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
