What Causes Lymphocytosis?
Discussion
Lymphocytes are an important part of the cellular and humoral immunity. Absolute lymphocyte count (ALC) is usually used to determine ranges of normal for lymphocytes. The ALC is higher in neonates and young children (up to 8000 cells/microL) but in those > 12 years of age is normally > 4000 cells/microL. Lymphopenia is usually defined as < 1000-1500 cells/microL. Infants again usually have higher counts or < 2500 cells/microL. Remember normal leukocyte count is 4.5-11.0 x 1000/mm2 with about 22-44% overall being lymphocytes.
Reactive lymphocytosis is when a patient without an underlying hematological problem ha...
Source: PediatricEducation.org - June 24, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Progression Of Glioblastoma May Be Accelerated By Cytomegalovirus
A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows. The animal study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) and at Dana Farber Cancer Institute suggests that cytomegalovirus (CMV) might significantly accelerate the development and progression of glioblastoma, a deadly form of brain cancer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 4, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Cytomegalovirus might speed brain-cancer growth
This study indicates that, in mice, a mouse CMV speeds the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells. The findings suggest that viruses might influence cancer progression, and that anti-viral therapy might improve the treatment of these aggressive brain tumors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 1, 2013 Category: Global & Universal Source Type: news
OHSU research highlights promising strategy to help vaccines outsmart HIV
(Oregon Health & Science University) A new discovery at Oregon Health and Science University highlights an ingenious method to ensure the body effectively reacts when infected with the highly-evasive HIV virus that causes AIDS. The method involves the use of cytomegalovirus as a vector to help a vaccine better instruct T cells how to identify and fight the virus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 24, 2013 Category: Global & Universal Source Type: news
Is EBV a Common Cause of Elevated Liver Enzymes?
Discussion
Infectious mononucleosis is caused by an Epstein-Barr Virus (EBV) infection causing the triad of fever, sore throat and adenopathy.
The differential diagnosis of clinical presentations similar to EBV includes:
Viral
Cytomegalovirus
Herpes simplex
Hepatitis A, B, C
HIV
Varicella
Bacterial/Spirochete
Brucellosis
Leptospirosis
Syphilis
Q fever
Miscellaneous
Autoimmune hepatitis
Drug side effects
Ischemia
Wilson Disease
Treatment for EBV infections is mainly supportive. Anti-viral medications such as ganciclovir are usually used for severe problems. Liver failure has been treated by transplant.
Refraining fr...
Source: PediatricEducation.org - April 1, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Well: Mental Health: Infections Tied to Dementia
Lower scores on tests of mental function were tied to exposure to common viruses and bacteria like herpes, cytomegalovirus, chlamydia and Helicobacter pylori. (Source: NYT Health)
Source: NYT Health - March 29, 2013 Category: Consumer Health News Authors: By NICHOLAS BAKALAR Tags: Infections Herpes Viruses Sexually Transmitted Diseases Dementia Helicobacter Pylori (Bacterium) Bacteria Mind Chlamydia Featured Source Type: news
Making Headway In Developing A Vaccine For The Leading Infectious Cause Of Congenital Birth Defects
A virus that most people have probably never heard of, yet most of us carry, is the number one infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb. Major research efforts are underway to combat this invidious disease. Researchers from Cardiff University and the La Jolla Institute, California, have discovered a previously unknown cellular mechanism that could prove critical in creating a CMV vaccine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 18, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news
Researchers Advance Fight Against Leading Infectious Cause Of Congenital Birth Defects
La Jolla Institute and Cardiff University Discovery Aids Efforts Toward Cytomegalovirus Vaccine A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the U.S. today. Because of cytomegalovirus (CMV) infection during in utero development, 1 in 750 children are born with or develop permanent disabilities such as hearing loss or brain damage. But efforts to develop a first-ever CMV vaccine are gaining ground... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 15, 2013 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news
Advancing Fight Against Leading Infectious Cause Of Congenital Birth Defects
A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the U.S. today. Because of cytomegalovirus (CMV) infection during in utero development, 1 in 750 children are born with or develop permanent disabilities such as hearing loss or brain damage. But efforts to develop a first-ever CMV vaccine are gaining ground... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 15, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news
Study Evaluates Clinical Manifestations Of Cytomegalovirus Associated Eye Infections In Patients Without HIV
JAMA Ophthalmology Study Highlights The medical records of 18 patients (22 affected eyes) were reviewed as part of a case series study in an academic research setting by Kessara Pathanapitoon, M.D., Ph.D., of Chiang Mai University, Thailand, and colleagues to describe the clinical manifestations and co-existing illnesses of patients without human immunodeficiency virus (HIV) infection who have cytomegalovirus (CMV) -associated posterior uveitis or panuveitis (inflammation)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 14, 2013 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news
Researchers advance fight against leading infectious cause of congenital birth defects
(La Jolla Institute for Allergy and Immunology) A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the US today. Because of cytomegalovirus (CMV) infection, 1 in 750 children are born with or develop permanent disabilities. But efforts to develop a CMV vaccine are gaining ground. Researchers from the La Jolla Institute and Cardiff University have discovered a cellular mechanism that could prove critical in creating a CMV vaccine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 13, 2013 Category: Global & Universal Source Type: news
Cytomegalovirus And Genes Involved In Causation Of Schizophrenia
For the first time, an international team of researchers has found that a combination of a particular virus in the mother and a specific gene variant in the child increases the risk of the child developing schizophrenia Viruses and genes interact in a way that may increase the risk of developing schizophrenia significantly. This happens already in the developing foetus. An international team of scientists led by Aarhus University, Denmark, has made this discovery... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 11, 2013 Category: Consumer Health News Tags: Schizophrenia Source Type: news
Voluntary Recall Announced for One Lot of Cidofovir Injection (Vistide) Solution
“Gilead Sciences, Inc. is voluntarily recalling lot B120217A of Vistide® (cidofovir injection) to the user level due to the presence of particulate matter found in some vials of this lot. Gilead is not currently aware of any complaint attributable to the particles. …
“Vistide is indicated for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). …
“Gilead has notified its distributors and customers by e-mail and recall letter and is arranging for return of all recalled product. Before injecting Vistide, healthcare providers s...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - February 22, 2013 Category: Infectious Diseases Source Type: news
CMV Retinitis Drug Recalled
(MedPage Today) -- One lot of cidofovir for intravenous infusion (Vistide), used to treat cytomegalovirus (CMV) retinitis in AIDS patients, has been recalled because of particulate matter in some vials, the FDA said. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - February 19, 2013 Category: Consumer Health News Source Type: news
What is Acute Hemorrhagic Edema of Infancy?
Discussion
The differential diagnosis for acute hemorrhagic edema of infancy (AHEI) is similar to purpura and includes:
Vascultitis
Henoch-Schonlein purpura (HSP)
Drug induced
Kawasaki disease
Rocky Mountain Spotted Fever
Trauma induced
Infectious Disease
Meningococcemia
Sepsis
Dermatologic
Erythema multiforme
Gianotti Crosti
Hemorrhagic urticaria
Sweet’s syndrome
Child maltreatment
Neonatal lupus
Learning Point
Acute hemorrhagic edema of infancy (AHEI, also called Seidlmayer or postinfectious cockade purpura, medallion-like purpura, or Finkelstein’s disease) is an uncommon, self-limited cutaneous leukocy...
Source: PediatricEducation.org - January 28, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
