Fetal and neonatal therapies improve prognosis of congenital cytomegalovirus infection
(Kobe University) A cross-institutional research group has revealed for the first time in the world that infants with symptomatic congenital cytomegalovirus (CMV) infection who were treated with a combination of immunoglobulin fetal therapy and neonatal therapy with antiviral drugs were less likely to experience the severe aftereffects associated with the infection than those who only received the neonatal therapy. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 28, 2021 Category: Infectious Diseases Source Type: news
Human Fetuses Can Contract SARS-CoV-2, but It's Rare
Compared with Zika and cytomegalovirus, the virus that causes COVID-19 appears to have a harder time penetrating the placenta and moving to a woman's unborn baby. (Source: The Scientist)
Source: The Scientist - January 1, 2021 Category: Science Tags: Features Magazine Issue Source Type: news
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre–COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVID-19 patient antibodies primarily recognized spike protein and nucleoprotein. A machine learning model trained on VirScan data...
Source: ScienceNOW - November 26, 2020 Category: Science Authors: Shrock, E., Fujimura, E., Kula, T., Timms, R. T., Lee, I.-H., Leng, Y., Robinson, M. L., Sie, B. M., Li, M. Z., Chen, Y., Logue, J., Zuiani, A., McCulloch, D., Lelis, F. J. N., Henson, S., Monaco, D. R., Travers, M., Habibi, S., Clarke, W. A., Caturegli, Tags: Immunology, Microbiology, Online Only r-articles Source Type: news
Researchers identify key marker to help speed development of CMV vaccines
(Duke University Medical Center) A Duke Health-led research team has identified a key marker that will help speed effective vaccine designs for cytomegalovirus (CMV), the most common congenital infection worldwide and a leading cause of infant brain damage. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 4, 2020 Category: Infectious Diseases Source Type: news
What Are Systemic Disease Causes of Oral Ulcers?
Discussion
Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range.
Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Source: PediatricEducation.org - September 21, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Roche receives FDA clearance for BK virus quantitative test on cobas 6800/8800 Systems to support better care for transplant patients
Basel, 8 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced U.S. Food and Drug Administration (FDA) 510k clearance for the cobas ® BKV Test on the cobas® 6800 and 8800 Systems. The test was previously granted FDA Breakthrough Device designation demonstrating the improved treatment or diagnosis of life-threatening diseases or conditions for transplant patients. The test provides standardised, high-quality results that can he lp healthcare professionals better assess the risk of complications caused by the BK virus in transplant patients and identify effective treatment options. BK virus (BKV) is a member ...
Source: Roche Media News - September 8, 2020 Category: Pharmaceuticals Source Type: news
Roche receives FDA clearance for BK virus quantitative test on cobas 6800/8800 Systems to support better care for transplant patients
Basel, 8 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced U.S. Food and Drug Administration (FDA) 510k clearance for the cobas ® BKV Test on the cobas® 6800 and 8800 Systems. The test was previously granted FDA Breakthrough Device designation demonstrating the improved treatment or diagnosis of life-threatening diseases or conditions for transplant patients. The test provides standardised, high-quality results that can he lp healthcare professionals better assess the risk of complications caused by the BK virus in transplant patients and identify effective treatment options. BK virus (BKV) is a member ...
Source: Roche Investor Update - September 8, 2020 Category: Pharmaceuticals Source Type: news
Researchers identify multiple molecules that shut down SARS-Cov-2 polymerase reaction
(Columbia University School of Engineering and Applied Science) Researchers at Columbia Engineering and the University of Wisconsin-Madison have identified a library of molecules that shut down the SARS-CoV-2 polymerase reaction, a key step that establishes the potential of these molecules as lead compounds to be further modified for the development of COVID-19 therapeutics. Five of these molecules are already FDA-approved for use in the treatment of other viral infections including HIV/AIDS, cytomegalovirus, and hepatitis B. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 30, 2020 Category: Infectious Diseases Source Type: news
Reactivation viremia in pediatric sepsis
Conclusion(s): Children with severe sepsis had low rates of detectable viremia, which limited analyses of its association with clinical outcomes or immune paralysis phenotype. Given the rare occurrence of cytomegalovirus viremia, in particular, our study does not support a role for viremia as a biomarker of illness severity or as a modifiable risk factor of clinical outcomes for most patients. Future studies on the role of viremia in pediatric sepsis will need to consider the challenges posed by low rates of viremia in this population. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news
Roche receives FDA approval for cobas HPV test for use on the cobas 6800/8800 Systems to identify women at risk for cervical cancer
Basel, 21 April 2020 - Roche (SIX: RO, ROG; OTCQX:RHHBY) today announced US Food and Drug Administration (FDA) approval for the cobas ® HPV test for use on the fully automated, high-throughput cobas® 6800/8800 Systems. The cobas® HPV test identifies women at risk for cervical cancer by detecting the presence of high-risk human papillomavirus (HPV) DNA in cervical samples. Persistent high-risk HPV infections can develop into pre cancerous lesions and, if left untreated, these lesions can progress to cervical cancer.“The approval of our HPV test for the cobas 6800 and 8800 Systems enables molec...
Source: Roche Media News - April 21, 2020 Category: Pharmaceuticals Source Type: news
Cytomegalovirus in Transplantation: Developing Drugs to Treat or Prevent Disease
Clinical / Antimicrobial (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 16, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Scientist uses 'mini brains' to model how to prevent development of abnormally small heads
(City of Hope) A scientist is one step closer to discovering what weakens a pathogen that appears to cause babies to be born with abnormally small heads or microcephaly. Studying 'mini brains,' or brain organoids, this scientist is hoping to get a grasp on how certain unborn babies infected with cytomegalovirus (CMV) develop microcephaly. She thinks she has developed a brain organoid model that can trace the pathogen and plans to test antiviral agents. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 27, 2020 Category: Infectious Diseases Source Type: news
Clinical factors during pregnancy related to congenital cytomegalovirus infection
(Kobe University) A group led by researchers from Kobe University has illuminated clinical factors that are related to the occurrence of congenital cytomegalovirus (CMV) infection in newborns. They revealed that fever or cold-like symptoms during pregnancy, and threatened miscarriage or threatened premature labor in the second trimester were associated with CMV infection in newborns. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 28, 2020 Category: Infectious Diseases Source Type: news
Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients
Patients who underwent an allogeneic hematopoietic stem cell transplant (HCT) experienced fewer cytomegalovirus (CMV)-related complications after Triplex vaccine injections in a phase-2, randomized, placebo-controlled trial.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - February 12, 2020 Category: Allergy & Immunology Tags: Transplantation News Source Type: news
City of Hope's Triplex vaccine reduces rate of CMV complications in transplant recipients
(City of Hope) Patients who underwent a stem cell transplant and received the Triplex vaccine to prevent a type of herpes virus -- cytomegalovirus (CMV) -- from duplicating out of control were 50% less likely to develop health complications related to the virus than patients who did not take Triplex, according to a City of Hope-led study published today in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 10, 2020 Category: Infectious Diseases Source Type: news
