High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index
Int J Cardiovasc Imaging. 2024 Apr 1. doi: 10.1007/s10554-024-03046-6. Online ahead of print.ABSTRACTIn the last century, there has been more than enough research that proved the association of high lipid and glucose levels with cardiovascular disease, thus establishing the current well-known traditional cardiovascular risk factors such as dyslipidemia, diabetes, and metabolic syndrome. Hence, these cardiovascular risk factors are target therapy for glucose and lipid-lowering agents to prevent adverse cardiovascular events. However, despite controlling the lipid and glucose levels, some studies demonstrated the subclinical...
Source: Atherosclerosis - April 1, 2024 Category: Cardiology Authors: Artemio Garc ía-Escobar Rosa L ázaro-García Jos é-Ángel Cabrera Alfonso Jurado-Rom án Ra úl Moreno Source Type: research
High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index
AbstractIn the last century, there has been more than enough research that proved the association of high lipid and glucose levels with cardiovascular disease, thus establishing the current well-known traditional cardiovascular risk factors such as dyslipidemia, diabetes, and metabolic syndrome. Hence, these cardiovascular risk factors are target therapy for glucose and lipid-lowering agents to prevent adverse cardiovascular events. However, despite controlling the lipid and glucose levels, some studies demonstrated the subclinical atherosclerosis suggesting that these cardiovascular risk factors alone cannot account for t...
Source: The International Journal of Cardiovascular Imaging - April 1, 2024 Category: Radiology Source Type: research
Evolution of cell therapy for renal cell carcinoma
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunothe... (Source: Molecular Cancer)
Source: Molecular Cancer - January 9, 2024 Category: Cancer & Oncology Authors: Yufei Wang, Eloah Rabello Suarez, Gabriella Kastrunes, Najla Santos Pacheco de Campos, Rabia Abbas, Renata Schmieder Pivetta, Nithyassree Murugan, Ghanbar Mahmoodi Chalbatani, Vincent D ’Andrea and Wayne A. Marasco Tags: Review Source Type: research
Facts and hopes on chimeric cytokine agents for cancer immunotherapy
Clin Cancer Res. 2024 Jan 8. doi: 10.1158/1078-0432.CCR-23-1160. Online ahead of print.ABSTRACTCytokines are key mediators of immune responses that can modulate the antitumor activity of immune cells. Cytokines have been explored as a promising cancer immunotherapy. However, there are several challenges to cytokine therapy, especially a lack of tumor targeting, resulting in high toxicity and limited efficacy. To overcome these limitations, novel approaches have been developed to engineer cytokines with improved properties, such as chimeric cytokines. Chimeric cytokines are fusion proteins that combine different cytokine do...
Source: Clinical Cancer Research - January 8, 2024 Category: Cancer & Oncology Authors: Zhenhua Ren Xuhao Zhang Yang-Xin Fu Source Type: research
Cancers, Vol. 15, Pages 5383: Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines
This article begins by addressing the role of the TMJ and its components in lung cancer. This review also highlights the functions of various cytokines such as interleukins (IL), transforming growth factor (TGF), and tumor necrosis factor (TNF). (Source: Cancers)
Source: Cancers - November 13, 2023 Category: Cancer & Oncology Authors: Freddy Elad Essogmo Angelina V. Zhilenkova Yvan Sinclair Ngaha Tchawe Abah Moses Owoicho Alexander S. Rusanov Alexander Boroda Yuliya N. Pirogova Zaiana D. Sangadzhieva Varvara D. Sanikovich Nikolay N. Bagmet Marina I. Sekacheva Tags: Review Source Type: research
The efficacy of molecular targeted therapy and nivolumab therapy for metastatic non ‐clear cell renal cell carcinoma: A retrospective analysis using the Michinoku Japan urological cancer study group database
ConclusionsThe results showed that the efficacy of molecular-targeted agents as first-line therapy was similar oncological outcomes between metastatic nccRCC and ccRCC in Japanese patients. TKIs may be more effective than mTORIs in metastatic nccRCC patients. Nivolumab administration might also be as effective in nccRCC patients as in ccRCC patients in Japanese population. (Source: Cancer Medicine)
Source: Cancer Medicine - October 31, 2023 Category: Cancer & Oncology Authors: Tomoyuki Koguchi,
Sei Naito,
Shingo Hatakeyama,
Kazuyuki Numakura,
Yumina Muto,
Renpei Kato,
Takahiro Kojima,
Yoshihide Kawasaki,
Kento Morozumi,
Shuya Kandori,
Sadafumi Kawamura,
Hiroyuki Nishiyama,
Akihiro Ito,
Tomonori Habuchi,
Wataru Oba Tags: RESEARCH ARTICLE Source Type: research
Current Trends on Innovative Technologies in Topical Wound Care for Advanced Healing and Management
CONCLUSION: Traditional wound treatments have been replaced by modern techniques such as stem cell therapy, growth factor/cytokine therapy, vacuum-assisted wound closure, and bioengineered skin substitutes. However, most of these strategies lack effectiveness and thorough evaluation. Therefore, further research is required to develop new techniques for cutaneous wound healing that are effective, cost-efficient, and appealing to patients.PMID:37807417 | DOI:10.2174/0125899775262048230925054922 (Source: Cell Research)
Source: Cell Research - October 9, 2023 Category: Cytology Authors: Qazi Saifullah Abhishek Sharma Source Type: research
Patients with metastatic renal cell carcinoma who receive immune-targeted therapy may derive survival benefit from nephrectomy
CONCLUSIONS: Nephrectomy may provide PFS benefit with tolerable safety for patients with metastatic renal cell carcinoma who receive immune-targeted therapy. In multivariate analysis, nephrectomy, clear cell carcinoma, and oligo-organ metastasis were found to be favorable independent prognostic factors.PMID:37803307 | DOI:10.1186/s12885-023-11408-x (Source: Cancer Control)
Source: Cancer Control - October 6, 2023 Category: Cancer & Oncology Authors: Hanzhi Dong Yuan Cao Yan Jian Jun Lei Weimin Zhou Xiaoling Yu Xiquan Zhang Zhiqiang Peng Zhe Sun Source Type: research
Patients with metastatic renal cell carcinoma who receive immune-targeted therapy may derive survival benefit from nephrectomy
CONCLUSIONS: Nephrectomy may provide PFS benefit with tolerable safety for patients with metastatic renal cell carcinoma who receive immune-targeted therapy. In multivariate analysis, nephrectomy, clear cell carcinoma, and oligo-organ metastasis were found to be favorable independent prognostic factors.PMID:37803307 | DOI:10.1186/s12885-023-11408-x (Source: Cancer Control)
Source: Cancer Control - October 6, 2023 Category: Cancer & Oncology Authors: Hanzhi Dong Yuan Cao Yan Jian Jun Lei Weimin Zhou Xiaoling Yu Xiquan Zhang Zhiqiang Peng Zhe Sun Source Type: research
Patients with metastatic renal cell carcinoma who receive immune-targeted therapy may derive survival benefit from nephrectomy
Nephrectomy, whether in the era of cytokine therapy or targeted therapy, has an important role in the treatment of metastatic renal cell carcinoma. With the advent of immunotherapy, immunotherapy combined with... (Source: BMC Cancer)
Source: BMC Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Hanzhi Dong, Yuan Cao, Yan Jian, Jun Lei, Weimin Zhou, Xiaoling Yu, Xiquan Zhang, Zhiqiang Peng and Zhe Sun Tags: Research Source Type: research
A comparative study on the influences of platelet-rich plasma vs its derived cytokines on skin rejuvenation
ConclusionsBoth therapies improved skin texture and elasticity. The efficacy rate was greater than the improvement for wrinkles. The effectiveness of nasolabial lines and facial lift was not significant. PRP-C therapy can be used as cell-free therapy.Level of evidence: level III, therapeutic study (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - September 24, 2023 Category: Cosmetic Surgery Source Type: research
Soybean lectin-triggered IL-6 secretion induces autophagy to kill intracellular mycobacteria through P2RX7 dependent activation of the JAK2/STAT3/Mcl-1 pathway
Cytokine. 2023 Sep 14;171:156366. doi: 10.1016/j.cyto.2023.156366. Online ahead of print.ABSTRACTCytokine therapy and cytokine-mediated autophagy have been used as prominent host-directed therapy (HDT) approaches to restrain M. tb growth in the host cell. In the present study, we have dissected the anti-tubercular activity of Soybean lectin (SBL) through cytokine-mediated autophagy induction in differentiated THP-1 (dTHP-1) cells. A significant increase in IL-6 expression was observed in both uninfected and mycobacteria infected dTHP-1 cells through the P2RX7 mediated pathway via PI3K/Akt/CREB-dependent signalling after SB...
Source: Cytokine - September 16, 2023 Category: Molecular Biology Authors: Abtar Mishra Ashish Kumar Lincoln Naik Salina Patel Mousumi Das Assirbad Behura Dev Kiran Nayak Amit Mishra Sujit K Bhutia Ramandeep Singh Rohan Dhiman Source Type: research
Soybean lectin-triggered IL-6 secretion induces autophagy to kill intracellular mycobacteria through P2RX7 dependent activation of the JAK2/STAT3/Mcl-1 pathway
Cytokine. 2023 Sep 14;171:156366. doi: 10.1016/j.cyto.2023.156366. Online ahead of print.ABSTRACTCytokine therapy and cytokine-mediated autophagy have been used as prominent host-directed therapy (HDT) approaches to restrain M. tb growth in the host cell. In the present study, we have dissected the anti-tubercular activity of Soybean lectin (SBL) through cytokine-mediated autophagy induction in differentiated THP-1 (dTHP-1) cells. A significant increase in IL-6 expression was observed in both uninfected and mycobacteria infected dTHP-1 cells through the P2RX7 mediated pathway via PI3K/Akt/CREB-dependent signalling after SB...
Source: Cytokine - September 16, 2023 Category: Molecular Biology Authors: Abtar Mishra Ashish Kumar Lincoln Naik Salina Patel Mousumi Das Assirbad Behura Dev Kiran Nayak Amit Mishra Sujit K Bhutia Ramandeep Singh Rohan Dhiman Source Type: research
Netherton syndrome in a Bulgarian patient
This article is mainly focused on innovative therapeutic options, including modern medications such as dupilumab, infliximab, secukinumab, anakinra, omalizumab, and others. (Source: Wiener Medizinische Wochenschrift)
Source: Wiener Medizinische Wochenschrift - September 1, 2023 Category: General Medicine Source Type: research
Advances in immunotherapy for biliary tract cancers
Chin Med J (Engl). 2023 Aug 29. doi: 10.1097/CM9.0000000000002759. Online ahead of print.ABSTRACTBiliary tract cancers (BTC) are a heterogeneous disease with poor prognosis, including gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICC), and extrahepatic cholangiocarcinoma (ECC). Although surgery is currently the primary regimen to treat BTC, most BTC patients are diagnosed at an advanced stage and miss the opportunity of surgical eradication. As a result, non-surgical therapy serves as the main intervention for advanced BTC. In recent years, immunotherapy has emerged as the one of the most promising therapies i...
Source: Chinese Medical Journal - August 30, 2023 Category: General Medicine Authors: Yuhao Zhao Mao Yang Jiayi Feng Xu'an Wang Yingbin Liu Source Type: research
