Seneca Valley virus induces proinflammatory cytokine and chemokine response < em > in vitro < /em >
Can J Vet Res. 2023 Apr;87(2):120-126.ABSTRACTSeneca Valley virus (SVV) is an oncolytic virus, which belongs to the Picornaviridae family, that causes blisters on the nose and hooves, affecting the production performance of pigs. However, the function of proinflammatory cytokines and chemokines in SVV infection is still unclear. In our study, SVV infection could induce a high expression of proinflammatory cytokines interleukin (IL)-1α, IL-1β, and tumor necrosis factor α (TNF-α) and chemokines, including chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 5 (CCL5), and chemokine (C-X-C motif) ligand 10 (...
Source: Canadian Journal of Veterinary Research - April 6, 2023 Category: Veterinary Research Authors: Jianguo Dong Mingrui Chen Linyang Yu Dan Rao Ning Zhang Feng Cong Source Type: research
Seneca Valley virus induces proinflammatory cytokine and chemokine response < em > in vitro < /em >
Can J Vet Res. 2023 Apr;87(2):120-126.ABSTRACTSeneca Valley virus (SVV) is an oncolytic virus, which belongs to the Picornaviridae family, that causes blisters on the nose and hooves, affecting the production performance of pigs. However, the function of proinflammatory cytokines and chemokines in SVV infection is still unclear. In our study, SVV infection could induce a high expression of proinflammatory cytokines interleukin (IL)-1α, IL-1β, and tumor necrosis factor α (TNF-α) and chemokines, including chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 5 (CCL5), and chemokine (C-X-C motif) ligand 10 (...
Source: Canadian Journal of Veterinary Research - April 6, 2023 Category: Veterinary Research Authors: Jianguo Dong Mingrui Chen Linyang Yu Dan Rao Ning Zhang Feng Cong Source Type: research
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas
CONCLUSIONS: These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.PMID:37014656 | DOI:10.1158/1078-0432.CCR-23-0006 (Source: Cell Research)
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca Kamerer Bahaa Fadl-Alla Jonathan Samuelson Elizabeth Fink Timothy M Fan K Dane Wittrup Source Type: research
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas
CONCLUSIONS: These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.PMID:37014656 | DOI:10.1158/1078-0432.CCR-23-0006 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 4, 2023 Category: Cancer & Oncology Authors: Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca Kamerer Bahaa Fadl-Alla Jonathan Samuelson Elizabeth Fink Timothy M Fan K Dane Wittrup Source Type: research
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas
CONCLUSIONS: These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.PMID:37014656 | DOI:10.1158/1078-0432.CCR-23-0006 (Source: Cell Research)
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca Kamerer Bahaa Fadl-Alla Jonathan Samuelson Elizabeth Fink Timothy M Fan K Dane Wittrup Source Type: research
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas
CONCLUSIONS: These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.PMID:37014656 | DOI:10.1158/1078-0432.CCR-23-0006 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 4, 2023 Category: Cancer & Oncology Authors: Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca Kamerer Bahaa Fadl-Alla Jonathan Samuelson Elizabeth Fink Timothy M Fan K Dane Wittrup Source Type: research
Reverse translation identifies the synergistic role of immune checkpoint blockade and IL-15 to enhance immunotherapy of ovarian cancer
Cancer Immunol Res. 2023 Feb 20:CIR-22-0600. doi: 10.1158/2326-6066.CIR-22-0600. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) has changed the standard of care for many patients with cancer, yet no ICB is approved for ovarian cancer. We hypothesized that maintenance therapy with an IL-15 "superagonist" (N-803) and ICB in combination could induce potent immune activation in ovarian cancer. Using flow cytometry, cytometry by time of flight (CyTOF) analysis, and cytotoxicity assays, we analyzed patient samples from women with advanced epithelial ovarian cancer treated with N-803 for indications of PD-1/PD-L1 ...
Source: Cancer Control - February 22, 2023 Category: Cancer & Oncology Authors: Martin Felices Erin Wesley Laura E Bendzick Behiye Kodal Rachel Hopps Bartosz Grzywacz Peter Hinderlie Jeffrey S Miller Melissa A Geller Source Type: research
Netherton syndrome in a Bulgarian patient
This article is mainly focused on innovative therapeutic options, including modern medications such as dupilumab, infliximab, secukinumab, anakinra, omalizumab, and others. (Source: Wiener Medizinische Wochenschrift)
Source: Wiener Medizinische Wochenschrift - January 25, 2023 Category: General Medicine Source Type: research
Natural peptides for immunological regulation in cancer therapy: Mechanism, facts and perspectives
Biomed Pharmacother. 2023 Jan 21;159:114257. doi: 10.1016/j.biopha.2023.114257. Online ahead of print.ABSTRACTCancer incidence and mortality rates are increasing annually. Treatment with surgery, chemotherapy and radiation therapy (RT) is unsatisfactory because many patients have advanced disease at the initial diagnosis. However, the emergence of immunotherapy promises to be an effective strategy to improve the outcome of advanced tumors. Immune checkpoint antibodies, which are at the forefront of immunotherapy, have had significant success but still leave some cancer patients without benefit. For more cancer patients to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 23, 2023 Category: Drugs & Pharmacology Authors: Yunchao Zhang Chenxin Liu Chunjie Wu Linjiang Song Source Type: research
Natural peptides for immunological regulation in cancer therapy: Mechanism, facts and perspectives
Biomed Pharmacother. 2023 Jan 21;159:114257. doi: 10.1016/j.biopha.2023.114257. Online ahead of print.ABSTRACTCancer incidence and mortality rates are increasing annually. Treatment with surgery, chemotherapy and radiation therapy (RT) is unsatisfactory because many patients have advanced disease at the initial diagnosis. However, the emergence of immunotherapy promises to be an effective strategy to improve the outcome of advanced tumors. Immune checkpoint antibodies, which are at the forefront of immunotherapy, have had significant success but still leave some cancer patients without benefit. For more cancer patients to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 23, 2023 Category: Drugs & Pharmacology Authors: Yunchao Zhang Chenxin Liu Chunjie Wu Linjiang Song Source Type: research
Surface-engineered nanoparticles in cancer immune response and immunotherapy: Current status and future prospects
Biomed Pharmacother. 2022 Nov 15;157:113998. doi: 10.1016/j.biopha.2022.113998. Online ahead of print.ABSTRACTCancer immunotherapy is a therapeutic strategy to inhibit tumor growth and metastasis by intervening in the immune response process. Strategies applied to cancer immunotherapy mainly include blocking immune checkpoints, adoptive transfer of engineered immune cells, cytokine therapy, cancer vaccines, and oncolytic virus infection. However, many factors, such as off-target side effects, immunosuppressive cell infiltration and/or upregulation of immune checkpoint expression, cancer cell heterogeneity, and lack of anti...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 18, 2022 Category: Drugs & Pharmacology Authors: Jun Chen Xiufeng Cong Source Type: research
Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management
Cytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T cell therapy, it is increasingly being described with other immunotherapies as well as following hematopoietic stem cell transplant. As its symptoms are nonspecific, awareness is key to timely diagnosis and initiation of treatment. Given the high risk of cardiopulmonary involvement, critical care providers must be familiar with the cause, symptoms, and therapeutic options. Current treatment modalities focus on immunosuppression and target...
Source: Critical Care Clinics - November 17, 2022 Category: Intensive Care Authors: Juliana Romano, Eric Wilsterman, Megan Toal, Christine Joyce Source Type: research
Dimethyl itaconate inhibits LPS-induced inflammatory release and apoptosis in alveolar type II epithelial and bronchial epithelial cells by activating pulmonary surfactant proteins A and D
CONCLUSION: The findings of the present study revealed that DMI inhibited LPS-induced inflammatory release and apoptosis in cells by targeting SIRT1 and then activating SP-A and SP-D. This novel insight into the pharmacological mechanism of DMI lays the foundation for its later use for alleviating lung injury.PMID:36335462 | DOI:10.15586/aei.v50i6.586 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 6, 2022 Category: Allergy & Immunology Authors: Yun Shi Huai-Qing Yin Source Type: research
Dimethyl itaconate inhibits LPS-induced inflammatory release and apoptosis in alveolar type II epithelial and bronchial epithelial cells by activating pulmonary surfactant proteins A and D
CONCLUSION: The findings of the present study revealed that DMI inhibited LPS-induced inflammatory release and apoptosis in cells by targeting SIRT1 and then activating SP-A and SP-D. This novel insight into the pharmacological mechanism of DMI lays the foundation for its later use for alleviating lung injury.PMID:36335462 | DOI:10.15586/aei.v50i6.586 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 6, 2022 Category: Allergy & Immunology Authors: Yun Shi Huai-Qing Yin Source Type: research
Dimethyl itaconate inhibits LPS-induced inflammatory release and apoptosis in alveolar type II epithelial and bronchial epithelial cells by activating pulmonary surfactant proteins A and D
CONCLUSION: The findings of the present study revealed that DMI inhibited LPS-induced inflammatory release and apoptosis in cells by targeting SIRT1 and then activating SP-A and SP-D. This novel insight into the pharmacological mechanism of DMI lays the foundation for its later use for alleviating lung injury.PMID:36335462 | DOI:10.15586/aei.v50i6.586 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 6, 2022 Category: Allergy & Immunology Authors: Yun Shi Huai-Qing Yin Source Type: research
